PMID- 29312479
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 9
IP  - 12
DP  - 2017
TI  - The effects of oral supplementation of spirulina platensis microalgae on 
      hematological parameters in streptozotocin-induced diabetic rats.
PG  - 5238-5244
AB  - It is shown that diabetes can change hematological parameters and some 
      microalgae, i.e. Spirulina platensis, could improve hematological parameters in 
      non-diabetic rats. The purpose of this study was to investigate the effects of 
      Spirulina platensis (SPM) microalgae on hematological parameters in diabetic rats 
      induced by Streptozotocin. Rats, 2.5 males old, were grouped into two sections 
      including healthy and diabetic and received orally 15 and 30 mg/kg body weight 
      SPM for 5 weeks. Control rats received 0.3 ml of distilled water. The 
      experimental groups were as follows; (SH15), healthy rats fed SPM (SH30) 30 
      mg/kg, diabetic rats fed 15 mg/kg SPM (SD15), diabetic rats fed SPM (SD30) 15 
      mg/kg, and diabetic control (DC). At the end of the test, blood samples were 
      collected to measure red blood cells, white blood cells, mean corpuscular 
      hemoglobin concentration (MCHC), mean cell volume (MCV) and packed cell volume 
      (PCV). The induction of diabetes decreased RBC, MCHC, PCV, MCV and WBC (P < 
      0.05), but the oral supplement of SPM (30 mg/kg body weight) could improve RBC, 
      WBC, MCHC, PCV and MCV in rats (P < 0.05). The oral complement of SPM, at high 
      levels, seems to be an effective strategy against the negative effects of 
      diabetes on hematological parameters.
FAU - Nasirian, Fariba
AU  - Nasirian F
AD  - Department of Animal Sciences, University of BirjandBirjand, Iran.
FAU - Mesbahzadeh, Behzad
AU  - Mesbahzadeh B
AD  - Assistant Professor, Cardiovascular Diseases Research Center, Department of 
      Physiology, School of Paramedical, Birjand Univesity of Medical SciencesBirjand, 
      Iran.
FAU - Maleki, Saeid Abbasi
AU  - Maleki SA
AD  - Young Researchers and Elite Club, Urmia Branch, Islamic Azad UniversityUrmia, 
      Iran.
FAU - Mogharnasi, Mehdi
AU  - Mogharnasi M
AD  - Associate Professor of Exercise Physiology, Department of Sport Sciences, 
      University of BirjandBirjand, Iran.
FAU - Kor, Nasroallah Moradi
AU  - Kor NM
AD  - Research Centre of Physiology, Faculty of Medicine, Semnan University of Medical 
      SciencesSemnan, Iran.
AD  - Student Research Committee, Faculty of Medicine, Semnan University of Medical 
      SciencesSemnan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20171215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC5752877
OTO - NOTNLM
OT  - Diabetic rats
OT  - Spirulina platensis
OT  - mean globular volume
OT  - red blood cell
OT  - white blood cell
COIS- None.
EDAT- 2018/01/10 06:00
MHDA- 2018/01/10 06:01
PMCR- 2017/12/15
CRDT- 2018/01/10 06:00
PHST- 2017/06/17 00:00 [received]
PHST- 2017/09/30 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/01/10 06:01 [medline]
PHST- 2017/12/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2017 Dec 15;9(12):5238-5244. eCollection 2017.