PMID- 29313576
OWN - NLM
STAT- MEDLINE
DCOM- 20180703
LR  - 20220318
IS  - 0004-5772 (Print)
IS  - 0004-5772 (Linking)
VI  - 65
IP  - 9
DP  - 2017 Sep
TI  - Pharmacological Reperfusion Therapy with Tenecteplase in 7,668 Indian Patients 
      with ST Elevation Myocardial Infarction - A Real World Indian Experience.
PG  - 43-47
AB  - OBJECTIVE: This real-world, observational, prescription event monitoring study 
      was conducted to evaluate safety and efficacy of indigenous tenecteplase 
      (TNK-tPA) in Indian patients presenting with ST elevation myocardial infarction 
      (STEMI). METHODS: This is a multi-centric, observational, prescription event 
      monitoring study. Data was collected for 7,668 patients from 1,307 investigator 
      sites across India from January 2011 to February 2016. RESULTS: Overall, 76.71% 
      patients were hypertensive, 47.97% patients were diabetic, 42.01% had 
      dyslipidemia, 24.35% had ischemic heart disease and 40.82% patients were smokers. 
      The overall rate for achieving clinically successful thrombolysis by TNK was 
      93.34%. Delayed administration of tenecteplase yielded lower success rate 
      (84.66%) as against those patients who received tenecteplase within 3 hours of 
      symptoms (94.34%). 93.2% patients had chest pain resolution after pharmacological 
      fibrinolysis. Overall 91.1% patients had 50% resolution of ST elevation at 90 
      minutes and mean time for 50% ST resolution was 72.06 minutes. Overall 53 
      patients died (mortality of 0.69%) before discharge. The incidence of bleeding 
      (excluding stroke) was 1.77%, any stroke without ICH was 0.18% and any ICH was 
      0.38%. CONCLUSION: The findings of this study further reinforce the safety and 
      efficacy of indigenous TNK-tPA in Indian patients presenting with STEMI, 
      including high-risk sub-groups. The study also highlights the importance of early 
      reperfusion therapy.
FAU - Iyengar, S S
AU  - Iyengar SS
AD  - Consultant Cardiologist, Manipal Hospital, Bangalore, Karnataka.
FAU - Nair, Tiny
AU  - Nair T
AD  - Head, Dept. of Cardiology, PRS Hospital, Trivandrum, Kerala.
FAU - Hiremath, Jagdish
AU  - Hiremath J
AD  - Director and Senior Interventional Cardiologist, Ruby Hall Clinic, Pune, 
      Maharashtra.
FAU - Dutta, Anjan Lal
AU  - Dutta AL
AD  - Consultant Cardiologist, Peerless Hospital, Kolkata, West Bengal.
FAU - Jadhav, Uday
AU  - Jadhav U
AD  - Consultant in Cardiology, MGM New Bombay Hospital, New Mumbai, Maharashtra.
FAU - Katyal, V K
AU  - Katyal VK
AD  - Senior Professor and Unit Head, Dept of Medicine, PGIMS, Rohtak, Haryana.
FAU - Kumbla, Dayanand
AU  - Kumbla D
AD  - Senior Interventional Cardiologist, Jupiter Hospital, Thane, India and Professor 
      (Cardiology), Rajiv Gandhi Medical College, Thane, Maharashtra.
FAU - Sathyamurthy, Immaneni
AU  - Sathyamurthy I
AD  - Senior Interventional Cardiologist, Apollo Hospitals, Chennai, Tamil Nadu.
FAU - Jain, R K
AU  - Jain RK
AD  - Senior Consultant Interventional Cardiologist, Krishna Institute of Medical 
      Sciences, Secunderabad, Hyderabad, Telangana.
FAU - Srinivasan, M
AU  - Srinivasan M
AD  - Former Professor of Cardiology, Madurai Medical College, Madurai, Tamil Nadu.
FAU - Sahoo, Prasant Kr
AU  - Sahoo PK
AD  - Sr. Consultant Cardiologist, Director Interventional Cardiology, Apollo 
      Hospitals, Bhubaneshwar, Orissa.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PL  - India
TA  - J Assoc Physicians India
JT  - The Journal of the Association of Physicians of India
JID - 7505585
RN  - 0 (Fibrinolytic Agents)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
RN  - WGD229O42W (Tenecteplase)
SB  - IM
MH  - Female
MH  - Fibrinolytic Agents/*therapeutic use
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Reperfusion
MH  - ST Elevation Myocardial Infarction/*drug therapy/epidemiology
MH  - Tenecteplase
MH  - *Thrombolytic Therapy
MH  - Time-to-Treatment
MH  - Tissue Plasminogen Activator/*therapeutic use
EDAT- 2018/01/10 06:00
MHDA- 2018/07/04 06:00
CRDT- 2018/01/10 06:00
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/07/04 06:00 [medline]
PST - ppublish
SO  - J Assoc Physicians India. 2017 Sep;65(9):43-47.