PMID- 29314660
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20221207
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Print)
IS  - 1582-1838 (Linking)
VI  - 22
IP  - 3
DP  - 2018 Mar
TI  - European versus Asian differences for the associations between paraoxonase-1 
      genetic polymorphisms and susceptibility to type 2 diabetes mellitus.
PG  - 1720-1732
LID - 10.1111/jcmm.13453 [doi]
AB  - Many studies have examined the associations between paraoxonase-1 (PON1) genetic 
      polymorphisms (Q192R, rs662 and L55M, rs854560) and the susceptibility to type 2 
      diabetes mellitus (T2DM) across different ethnic populations. However, the 
      evidence for the associations remains inconclusive. In this study, we performed a 
      meta-analysis to clarify the association of the two PON1 variants with T2DM risk. 
      We carried out a systematic search of PubMed, Embase, CNKI and Wanfang databases 
      for studies published before June 2017. The pooled odds ratios (ORs) for the 
      association and their corresponding 95% confidence intervals (CIs) were 
      calculated by a random- or fixed-effect model. A total of 50 eligible studies, 
      including 34 and 16 studies were identified for the PON1 Q192R (rs662) and L55M 
      (rs854560) polymorphism, respectively. As for the PON1 Q192R polymorphism, the 
      192R allele was a susceptible factor of T2DM in the South or East Asian 
      population (OR > 1, P < 0.05) but represented a protective factor of T2DM in 
      European population (OR = 0.66, 95% CI = 0.45-0.98) under a heterozygous genetic 
      model. With regard to the PON1 L55M polymorphism, significant protective effects 
      of the 55M allele on T2DM under the heterozygous (OR = 0.77, 95% CI = 0.61-0.97) 
      and dominant (OR = 0.80, 95% CI = 0.65-0.99) genetic models were found in the 
      European population, while no significant associations in the Asian populations 
      under all genetic models (P > 0.05). In summary, by a comprehensive 
      meta-analysis, our results firmly indicated that distinct effects of PON1 genetic 
      polymorphisms existed in the risk of T2DM across different ethnic backgrounds.
CI  - (c) 2018 The Authors. Journal of Cellular and Molecular Medicine published by John 
      Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
FAU - Luo, Jian-Quan
AU  - Luo JQ
AUID- ORCID: 0000-0002-2912-4205
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
AD  - Institute of Clinical Pharmacy, Central South University, Changsha, Hunan, China.
FAU - Ren, Huan
AU  - Ren H
AD  - Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 
      Changsha, China.
AD  - Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, 
      Central South University, Changsha, China.
FAU - Liu, Mou-Ze
AU  - Liu MZ
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
AD  - Institute of Clinical Pharmacy, Central South University, Changsha, Hunan, China.
FAU - Fang, Ping-Fei
AU  - Fang PF
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
AD  - Institute of Clinical Pharmacy, Central South University, Changsha, Hunan, China.
FAU - Xiang, Da-Xiong
AU  - Xiang DX
AD  - Department of Pharmacy, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
AD  - Institute of Clinical Pharmacy, Central South University, Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20180104
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
SB  - IM
MH  - Alleles
MH  - Aryldialkylphosphatase/*genetics
MH  - Asian People/genetics
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - White People/genetics
PMC - PMC5824408
OTO - NOTNLM
OT  - ethnic difference
OT  - paraoxonase-1
OT  - polymorphism
OT  - susceptibility
OT  - type 2 diabetes mellitus
EDAT- 2018/01/10 06:00
MHDA- 2019/10/23 06:00
PMCR- 2018/03/01
CRDT- 2018/01/10 06:00
PHST- 2017/08/01 00:00 [received]
PHST- 2017/10/12 00:00 [accepted]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - JCMM13453 [pii]
AID - 10.1111/jcmm.13453 [doi]
PST - ppublish
SO  - J Cell Mol Med. 2018 Mar;22(3):1720-1732. doi: 10.1111/jcmm.13453. Epub 2018 Jan 
      4.