PMID- 29314670
OWN - NLM
STAT- MEDLINE
DCOM- 20190515
LR  - 20210109
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 21
IP  - 1
DP  - 2018 Jan
TI  - Eliminating hepatitis C virus as a public health threat among HIV-positive men 
      who have sex with men: a multi-modelling approach to understand differences in 
      sexual risk behaviour.
LID - 10.1002/jia2.25059 [doi]
LID - e25059
AB  - INTRODUCTION: Outbreaks of hepatitis C virus (HCV) infections among HIV-positive 
      men who have sex with men (MSM) have been observed globally. Using a 
      multi-modelling approach we estimate the time and number of direct-acting 
      antiviral treatment courses required to achieve an 80% reduction in HCV 
      prevalence among HIV-positive MSM in the state of Victoria, Australia. METHODS: 
      Three models of HCV transmission, testing and treatment among MSM were compared: 
      a dynamic compartmental model; an agent-based model (ABM) parametrized to local 
      surveillance and behavioural data ("ABM1"); and an ABM with a more heterogeneous 
      population ("ABM2") to determine the influence of extreme variations in sexual 
      risk behaviour. RESULTS: Among approximately 5000 diagnosed HIV-positive MSM in 
      Victoria, 10% are co-infected with HCV. ABM1 estimated that an 80% reduction in 
      HCV prevalence could be achieved in 122 (inter-quartile range (IQR) 112 to 133) 
      weeks with 523 (IQR 479 to 553) treatments if the average time from HCV diagnosis 
      to treatment was six months. This was reduced to 77 (IQR 69 to 81) weeks if the 
      average time between HCV diagnosis and treatment commencement was decreased to 
      16 weeks. Estimates were consistent across modelling approaches; however ABM2 
      produced fewer incident HCV cases, suggesting that treatment-as-prevention may be 
      more effective in behaviourally heterogeneous populations. CONCLUSIONS: Major 
      reductions in HCV prevalence can be achieved among HIV-positive MSM within two 
      years through routine HCV monitoring and prompt treatment as a part of HIV care. 
      Compartmental models constructed with limited behavioural data are likely to 
      produce conservative estimates compared to models of the same setting with more 
      complex parametrizations.
CI  - (c) 2018 The Authors. Journal of the International AIDS Society published by John 
      Wiley & sons Ltd on behalf of the International AIDS Society.
FAU - Scott, Nick
AU  - Scott N
AUID- ORCID: 0000-0002-9213-0798
AD  - Disease Elimination Program, Burnet Institute, Melbourne, Vic., Australia.
AD  - Department of Epidemiology and Preventive Medicine, Monash University, Clayton, 
      Vic., Australia.
FAU - Stoove, Mark
AU  - Stoove M
AD  - Disease Elimination Program, Burnet Institute, Melbourne, Vic., Australia.
AD  - Department of Epidemiology and Preventive Medicine, Monash University, Clayton, 
      Vic., Australia.
FAU - Wilson, David P
AU  - Wilson DP
AD  - Disease Elimination Program, Burnet Institute, Melbourne, Vic., Australia.
FAU - Keiser, Olivia
AU  - Keiser O
AD  - Institute of Social and Preventive Medicine, University of Bern, Bern, 
      Switzerland.
FAU - El-Hayek, Carol
AU  - El-Hayek C
AD  - Disease Elimination Program, Burnet Institute, Melbourne, Vic., Australia.
FAU - Doyle, Joseph
AU  - Doyle J
AD  - Disease Elimination Program, Burnet Institute, Melbourne, Vic., Australia.
AD  - Department of Infectious Diseases, The Alfred and Monash University, Melbourne, 
      Vic., Australia.
FAU - Hellard, Margaret
AU  - Hellard M
AD  - Disease Elimination Program, Burnet Institute, Melbourne, Vic., Australia.
AD  - Department of Epidemiology and Preventive Medicine, Monash University, Clayton, 
      Vic., Australia.
AD  - Department of Infectious Diseases, The Alfred and Monash University, Melbourne, 
      Vic., Australia.
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
SB  - IM
MH  - HIV Infections/*complications
MH  - Hepatitis C/drug therapy/*prevention & control
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - *Public Health
MH  - *Risk-Taking
MH  - *Sexual Behavior
PMC - PMC5810343
OTO - NOTNLM
OT  - HIV
OT  - agent-based model
OT  - coinfection
OT  - elimination
OT  - hepatitis C virus
OT  - men who have sex with men
OT  - multi-modelling
EDAT- 2018/01/10 06:00
MHDA- 2019/05/16 06:00
PMCR- 2018/01/09
CRDT- 2018/01/10 06:00
PHST- 2016/12/06 00:00 [received]
PHST- 2017/12/18 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2019/05/16 06:00 [medline]
PHST- 2018/01/09 00:00 [pmc-release]
AID - JIA225059 [pii]
AID - 10.1002/jia2.25059 [doi]
PST - ppublish
SO  - J Int AIDS Soc. 2018 Jan;21(1):e25059. doi: 10.1002/jia2.25059.