PMID- 2931621
OWN - NLM
STAT- MEDLINE
DCOM- 19851104
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 58
IP  - 1
DP  - 1985 Jul 4
TI  - Antidipsogenic action of alpha-human atrial natriuretic polypeptide administered 
      intracerebroventricularly in rats.
PG  - 1-6
AB  - Intracerebroventricular (i.c.v.) administration of alpha-human atrial natriuretic 
      polypeptide (alpha-hANP) in a dose of 5 micrograms did not change water intake in 
      normal rats, while 0.1 micrograms of angiotensin II (AII) and 0.5 micrograms of 
      carbachol caused a marked increase in water intake for 30 min after i.c.v. 
      injections. The water intake induced by 0.1 micrograms of AII was significantly 
      suppressed by the simultaneous administration of 2 and 5 micrograms of 
      alpha-hANP. However, alpha-hANP did not affect the water intake caused by 0.5 
      micrograms of carbachol. In 24-h water-deprived rats, alpha-hANP in doses of 2 
      and 5 micrograms pronouncedly inhibited the water intake. alpha-hANP did not 
      change the food intake in 24-h fasted rats nor the locomotor activity in normal 
      rats. These findings suggest that alpha-hANP in the central nervous system may 
      play an important role in controlling drinking behavior, interacting with AII.
FAU - Nakamura, M
AU  - Nakamura M
FAU - Katsuura, G
AU  - Katsuura G
FAU - Nakao, K
AU  - Nakao K
FAU - Imura, H
AU  - Imura H
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 11128-99-7 (Angiotensin II)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - 8Y164V895Y (Carbachol)
SB  - IM
MH  - Angiotensin II/antagonists & inhibitors
MH  - Animals
MH  - Atrial Natriuretic Factor/*pharmacology
MH  - Carbachol/pharmacology
MH  - Drinking/*drug effects
MH  - Eating/drug effects
MH  - Fasting
MH  - Humans
MH  - Injections, Intraventricular
MH  - Male
MH  - Motor Activity/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Water Deprivation
EDAT- 1985/07/04 00:00
MHDA- 1985/07/04 00:01
CRDT- 1985/07/04 00:00
PHST- 1985/07/04 00:00 [pubmed]
PHST- 1985/07/04 00:01 [medline]
PHST- 1985/07/04 00:00 [entrez]
AID - 0304-3940(85)90319-2 [pii]
AID - 10.1016/0304-3940(85)90319-2 [doi]
PST - ppublish
SO  - Neurosci Lett. 1985 Jul 4;58(1):1-6. doi: 10.1016/0304-3940(85)90319-2.