PMID- 29316404
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20190221
IS  - 1208-6002 (Electronic)
IS  - 0829-8211 (Linking)
VI  - 96
IP  - 5
DP  - 2018 Oct
TI  - The CXCL12-CXCR4 axis promotes migration, invasiveness, and EMT in human 
      papillary thyroid carcinoma B-CPAP cells via NF-kappaB signaling.
PG  - 619-626
LID - 10.1139/bcb-2017-0074 [doi]
AB  - Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy involving 
      local and distant metastasis. It is known that CXC chemokine ligand 12 (CXCL12) 
      interacts specifically with CXC chemokine receptor 4 (CXCR4) to guide the 
      migration of PTC cells. However, the signaling pathway downstream of the 
      CXCL12-CXCR4 axis in PTC is not fully understood. In the present study, high 
      expression of CXCR4 was detected in 38 out of 82 specimens of PTC, and the 
      expression level of CXCR4 significantly correlated with the stage of PTC. 
      Additionally, the roles of the CXCL12-CXCR4 axis in the migration, invasion, and 
      epithelial-mesenchymal transition (EMT) of B-CPAP cells were investigated in 
      vitro. The motility and invasiveness were significantly enhanced in 
      CXCR4-overexpressing B-CPAP cells with CXCL12 treatment. Moreover, the 
      CXCL12-CXCR4 axis promoted the EMT process, as evidenced by a decreased level of 
      E-cadherin and increased expressions of N-cadherin and vimentin. Furthermore, the 
      CXCL12-CXCR4 axis activated the nuclear factor kappa-B (NF-kappaB) signaling pathway, 
      whereas BAY11-7082, an IkappaB phosphorylation inhibitor, counteracted 
      CXCL12-CXCR4-induced migration, invasion, and EMT processes in B-CPAP cells. In 
      conclusion, the CXCL12-CXCR4 axis promotes the migration, invasion, and EMT 
      processes in B-CPAP cells, at least partly, by activating the NF-kappaB signaling 
      pathway.
FAU - Lin, Yuanqiang
AU  - Lin Y
AD  - a Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, 
      Changchun 130033, People's Republic of China.
FAU - Ma, Qingjie
AU  - Ma Q
AD  - a Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, 
      Changchun 130033, People's Republic of China.
FAU - Li, Lin
AU  - Li L
AD  - b Department of Otolaryngology-Head and Neck Surgery, China-Japan Union Hospital 
      of Jilin University, Changchun 130033, People's Republic of China.
FAU - Wang, Hui
AU  - Wang H
AD  - c Department of Ultrasound, China-Japan Union Hospital of Jilin University, 
      Changchun 130033, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20180109
PL  - Canada
TA  - Biochem Cell Biol
JT  - Biochemistry and cell biology = Biochimie et biologie cellulaire
JID - 8606068
RN  - 0 (CXCL12 protein, human)
RN  - 0 (CXCR4 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (NF-kappa B)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Adult
MH  - Carcinoma, Papillary/*metabolism/pathology
MH  - Cell Line, Tumor
MH  - *Cell Movement
MH  - Chemokine CXCL12/*metabolism
MH  - *Epithelial-Mesenchymal Transition
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B/*metabolism
MH  - Neoplasm Invasiveness
MH  - Neoplasm Proteins/*metabolism
MH  - Receptors, CXCR4/*metabolism
MH  - *Signal Transduction
MH  - Thyroid Cancer, Papillary
MH  - Thyroid Neoplasms/*metabolism/pathology
OTO - NOTNLM
OT  - CXCL12
OT  - CXCR4
OT  - NF-kappaB
OT  - SDF-1
OT  - carcinome papillaire de la thyroide
OT  - papillary thyroid carcinoma
EDAT- 2018/01/10 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/01/10 06:00
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/01/10 06:00 [entrez]
AID - 10.1139/bcb-2017-0074 [doi]
PST - ppublish
SO  - Biochem Cell Biol. 2018 Oct;96(5):619-626. doi: 10.1139/bcb-2017-0074. Epub 2018 
      Jan 9.