PMID- 29317051
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20180827
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 110
DP  - 2018 Jan
TI  - The end-stage failing human myocardium - Where changes in ultrastructure of human 
      cardiac muscle cells do not appear to dictate clinical outcomes.
PG  - 105-109
LID - S0306-9877(17)31080-0 [pii]
LID - 10.1016/j.mehy.2017.12.005 [doi]
AB  - Heart failure is the end stage of cardiovascular abnormalities. Studies have 
      primarily focused on the functional changes of cardiomyocytes in the failing 
      heart from different animal models with very little information in the human 
      condition. In addition little is known about the ultrastructural changes that 
      proceed in cardiomyocytes in route to failure. The aim of this study was to 
      examine the ultrastructural changes in the myocardium of human with end-stage 
      heart failure. Left ventricular myocardial tissue samples from 7 patients with 
      end-stage heart failure were examined with transmission and scanning electron 
      microscopy. All heart failure patients were of New York Heart Association (NYHA) 
      class III-IV. The data indicated normal three-dimensional arrangement of cardiac 
      muscle cells in failing myocardium. The various organelles in cardiomyocytes 
      including the nucleus, mitochondria, myofibrils, T-tubules and intercalated discs 
      did not exhibit any remarkable morphological changes. We did observe the 
      appearance of small membrane bound vesicles which appear to be associated with 
      the intercalated discs. The nearly normal ultrastructure and arrangement of 
      cardiomyocytes was remarkable in contrast to the dramatic clinical status of 
      these patients in heart failure. These observations support the hypothesis, that 
      there are no dramatic changes in the ultrastructure or three-dimensional 
      architecture of cardiomyocytes in end-stage failing human myocardium.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Varga, Ivan
AU  - Varga I
AD  - Institute of Histology and Embryology, Faculty of Medicine, Comenius University, 
      Spitalska Street 24, SK-81372 Bratislava, Slovakia. Electronic address: 
      ivan.varga@fmed.uniba.sk.
FAU - Galfiova, Paulina
AU  - Galfiova P
AD  - Institute of Histology and Embryology, Faculty of Medicine, Comenius University, 
      Spitalska Street 24, SK-81372 Bratislava, Slovakia.
FAU - Gazova, Andrea
AU  - Gazova A
AD  - Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, 
      Comenius University, Spitalska Street 24, SK-81372 Bratislava, Slovakia.
FAU - Barczi, Tomas
AU  - Barczi T
AD  - Institute of Anatomy, Faculty of Medicine, Comenius University, Spitalska Street 
      24, SK-81372 Bratislava, Slovakia.
FAU - Polak, Stefan
AU  - Polak S
AD  - Institute of Histology and Embryology, Faculty of Medicine, Comenius University, 
      Spitalska Street 24, SK-81372 Bratislava, Slovakia.
FAU - Danisovic, Lubos
AU  - Danisovic L
AD  - Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of 
      Medicine, Comenius University, Spitalska Street 24, SK-81372 Bratislava, 
      Slovakia.
FAU - Hulman, Michal
AU  - Hulman M
AD  - Department of Heart Surgery, The National Institute of Cardiovascular Diseases 
      and Faculty of Medicine, Slovak Medical University, Pod Krasnou Horkou 1, SK-833 
      48 Bratislava, Slovakia.
FAU - Kyselovic, Jan
AU  - Kyselovic J
AD  - Fifth Department of Internal Medicine, Faculty of Medicine, Comenius University, 
      Spitalska Street 24, SK-81372 Bratislava, Slovakia.
LA  - eng
PT  - Journal Article
DEP - 20171205
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
SB  - IM
MH  - Adult
MH  - Animals
MH  - Female
MH  - Heart Failure/*pathology/physiopathology
MH  - Heart Ventricles/ultrastructure
MH  - Humans
MH  - Intercellular Junctions/ultrastructure
MH  - Male
MH  - Microscopy, Electron, Scanning
MH  - Microscopy, Electron, Transmission
MH  - Middle Aged
MH  - Mitochondria, Heart/ultrastructure
MH  - Models, Cardiovascular
MH  - Myocardium/ultrastructure
MH  - Myocytes, Cardiac/*ultrastructure
MH  - Myofibrils/ultrastructure
OTO - NOTNLM
OT  - Failing heart
OT  - Myocardium
OT  - Scanning electron microscopy
OT  - Transmission electron microscopy
OT  - Ultrastructural morphology
EDAT- 2018/01/11 06:00
MHDA- 2018/08/28 06:00
CRDT- 2018/01/11 06:00
PHST- 2017/10/15 00:00 [received]
PHST- 2017/11/03 00:00 [revised]
PHST- 2017/12/01 00:00 [accepted]
PHST- 2018/01/11 06:00 [entrez]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
AID - S0306-9877(17)31080-0 [pii]
AID - 10.1016/j.mehy.2017.12.005 [doi]
PST - ppublish
SO  - Med Hypotheses. 2018 Jan;110:105-109. doi: 10.1016/j.mehy.2017.12.005. Epub 2017 
      Dec 5.