PMID- 29317959
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 10
IP  - 2
DP  - 2018 Feb
TI  - Impact of Oxidative Stress and Newer Antiepileptic Drugs on the Albumin and 
      Cortisol Value in Severe Motor and Intellectual Disabilities With Epilepsy.
PG  - 137-145
LID - 10.14740/jocmr3289w [doi]
AB  - BACKGROUND: Epilepsy is a common complication in patients with severe motor and 
      intellectual disabilities (SMID). There are no reports as yet of the effects of 
      these medications in vivo other than their epileptic efficacy. The purpose of 
      this study was to clarify the effects of the newer antiepileptic drugs (AEDs) on 
      the blood biochemical parameters and oxidative stress in SMID with epilepsy by 
      comparing the therapeutic effects between a group of patients receiving 
      lamotrigine (LTG) and levetiracetam (LEV) in addition to the conventional AEDs 
      (newer AED group) and a group receiving conventional AEDs alone (old AED group). 
      METHODS: The study population consisted of 44 SMID patients with epilepsy, of 
      which 23 were allocated to the newer AED group and 21 were allocated to the old 
      AED group. In the newer AED group, measurements of the reactive oxygen 
      metabolites (d-ROMs), biological antioxidant potential (BAP) and serum albumin 
      were carried out at the following two time points: 1 week before and 1 year after 
      the start of administration of the newer AEDs. In the old AED group, measurements 
      of the same variables were performed at two time points 1 year apart. RESULTS: A 
      significant decrease of the d-ROM levels and a significant increase of the BAP 
      were noted in the newer AED group. A significant elevation of the serum albumin 
      was also evident. In the old AED group, a significant increase of the d-ROMs 
      levels was noted at the second measurement. Cortisol levels which have been 
      described to be related to the albumin, revealed a significant decrease of the 
      serum cortisol in relation to elevation of serum albumin in the newer AED group. 
      CONCLUSIONS: The present study results suggest that the addition of newer AEDs 
      reduces the oxidative stress load and improves the antioxidant potential of the 
      body. Furthermore, the present data also demonstrate that the newer AEDs have 
      indirect impact on biological parameters.
FAU - Morimoto, Masahito
AU  - Morimoto M
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with 
      Disabilities, Tokushima, Japan.
FAU - Hashimoto, Toshiaki
AU  - Hashimoto T
AD  - Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People with 
      Disabilities, Tokushima, Japan.
FAU - Kitaoka, Taisuke
AU  - Kitaoka T
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan.
FAU - Kyotani, Shojiro
AU  - Kyotani S
AD  - Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, 
      Tokushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171230
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC5755653
OTO - NOTNLM
OT  - Albumin
OT  - Cortisol
OT  - Epilepsy
OT  - Oxidative stress
OT  - Severe motor and intellectual disabilities
COIS- There is no conflict of interest to be disclosed.
EDAT- 2018/01/11 06:00
MHDA- 2018/01/11 06:01
PMCR- 2017/12/30
CRDT- 2018/01/11 06:00
PHST- 2017/12/04 00:00 [received]
PHST- 2017/12/20 00:00 [accepted]
PHST- 2018/01/11 06:00 [entrez]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/01/11 06:01 [medline]
PHST- 2017/12/30 00:00 [pmc-release]
AID - 10.14740/jocmr3289w [doi]
PST - ppublish
SO  - J Clin Med Res. 2018 Feb;10(2):137-145. doi: 10.14740/jocmr3289w. Epub 2017 Dec 
      30.