PMID- 29318069
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2090-6706 (Print)
IS  - 2090-6714 (Electronic)
VI  - 2017
DP  - 2017
TI  - Myelodysplasia and Mast Cell Leukemia with t(9;22).
PG  - 9249302
LID - 10.1155/2017/9249302 [doi]
LID - 9249302
AB  - INTRODUCTION: Mast cell leukemia (MCL) is a rare variant of systemic 
      mastocytosis. Most cases of mast cell leukemia do not have cytogenics performed. 
      Furthermore, there is no consistent chromosomal abnormality identified in MCL. 
      This is the first reported case of MCL with a (9;22) translocation. CASE REPORT: 
      An 80-year-old female presented with pancytopenia and was diagnosed with MDS. 
      Over time, she required hospitalizations for platelet transfusions with increased 
      frequency. She developed fatigue and weakness along with gastrointestinal 
      symptoms. On exam, she had diffuse abdominal tenderness and a maculopapular rash. 
      Her lab results revealed a new basophilia. A bone marrow biopsy showed 100% 
      cellularity with many aggregates of mast cells. Chromosomal analysis showed 
      t(9;22) with confirmed BCR/ABL1 fusion by fluorescence in situ hybridization 
      (FISH). DISCUSSION: MCL has a poor prognosis due to the aggressive nature of the 
      disease and ineffective therapies. Translocation (9;22) is known to be associated 
      with MDS transformations to acute leukemia; however, this translocation has never 
      been reported in MCL. Further research on the relationship between t(9;22) and 
      MCL could lead to development of improved therapeutic options.
FAU - Lago, Kathryn J
AU  - Lago KJ
AUID- ORCID: 0000-0002-3951-1938
AD  - Internal Medicine Service, San Antonio Military Medical Center, Fort Sam Houston, 
      San Antonio, TX, USA.
FAU - Shupe, Matthew P
AU  - Shupe MP
AD  - Hematology and Oncology Service, San Antonio Military Medical Center, Fort Sam 
      Houston, San Antonio, TX, USA.
FAU - Hannah, William N
AU  - Hannah WN
AD  - Internal Medicine Service, San Antonio Military Medical Center, Fort Sam Houston, 
      San Antonio, TX, USA.
FAU - Velagaleti, Gopalrao V N
AU  - Velagaleti GVN
AUID- ORCID: 0000-0003-2811-8185
AD  - Department of Pathology, University of Texas Health Science Center, San Antonio, 
      TX, USA.
FAU - Mendiola, Christina
AU  - Mendiola C
AD  - Department of Pathology, University of Texas Health Science Center, San Antonio, 
      TX, USA.
FAU - Ortega, Veronica
AU  - Ortega V
AD  - Department of Pathology, University of Texas Health Science Center, San Antonio, 
      TX, USA.
FAU - Haney, Brian R
AU  - Haney BR
AD  - Hematology and Oncology Service, San Antonio Military Medical Center, Fort Sam 
      Houston, San Antonio, TX, USA.
LA  - eng
PT  - Case Reports
DEP - 20171126
PL  - United States
TA  - Case Rep Oncol Med
JT  - Case reports in oncological medicine
JID - 101581035
PMC - PMC5727626
EDAT- 2018/01/11 06:00
MHDA- 2018/01/11 06:01
PMCR- 2017/11/26
CRDT- 2018/01/11 06:00
PHST- 2017/07/28 00:00 [received]
PHST- 2017/10/13 00:00 [revised]
PHST- 2017/10/25 00:00 [accepted]
PHST- 2018/01/11 06:00 [entrez]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/01/11 06:01 [medline]
PHST- 2017/11/26 00:00 [pmc-release]
AID - 10.1155/2017/9249302 [doi]
PST - ppublish
SO  - Case Rep Oncol Med. 2017;2017:9249302. doi: 10.1155/2017/9249302. Epub 2017 Nov 
      26.