PMID- 29318394
OWN - NLM
STAT- MEDLINE
DCOM- 20180626
LR  - 20220331
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 19
IP  - 1
DP  - 2018 Jan 9
TI  - Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a 
      Chinese population-based case-control study.
PG  - 1
LID - 10.1186/s10194-017-0831-1 [doi]
LID - 1
AB  - BACKGROUND: Cluster headache (CH), a rare primary headache disorder, is currently 
      thought to be a genetic susceptibility which play a role in CH susceptibility. A 
      large numbers of genetic association studies have confirmed that the HCRTR2 
      (Hypocretin Receptor 2) SNP rs2653349, and the ADH4 (Alcohol Dehydrogenase 4) SNP 
      rs1126671 and rs1800759 polymorphisms are linked to CH. In addition, the CLOCK 
      (Circadian Locomotor Output Cycles Kaput) gene is becoming a research hotspot for 
      CH due to encoding a transcription factor that serves as a basic driving force 
      for circadian rhythm in humans. The purpose of this study was to evaluate the 
      association between CH and the HCRTR2, ADH4 and CLOCK genes in a Chinese CH 
      case-control sample. METHODS: We genotyped polymorphisms of nine single 
      nucleotide polymorphisms (SNPs) in the HCRTR2, ADH4 and CLOCK genes to perform an 
      association study on a Chinese Han CH case-control sample (112 patients and 192 
      controls),using Sequenom MALDI-TOF mass spectrometry iPLEX platform. The 
      frequencies and distributions of genotypes and haplotypes were statistically 
      compared between the case and control groups to identify associations with CH. 
      The effects of SNPs on CH were further investigated by multiple logistic 
      regression. RESULTS: The frequency of the HCRTR2 SNP rs3800539 GA genotype was 
      significantly higher in cases than in controls (48.2% vs.37.0%). The GA genotypes 
      was associated with a higher CH risk (OR = 1.483, 95% CI: 0.564-3.387, 
      p = 0.038), however, after Bonferroni correction, the association lost 
      statistical significance. Haplotype analysis of the HCRTR2 SNPs showed that among 
      eight haplotypes, only H1-GTGGGG was linked to a reduced CH risk (44.7% vs. 
      53.1%, OR = 0.689, 95% CI =0.491~0.966, p = 0.030). No significant association of 
      ADH4, CLOCK SNPs with CH was statistically detected in the present study. 
      CONCLUSIONS: Association between HCRTR2, ADH4,CLOCK gene polymorphisms and CH was 
      not significant in the present study, however, haplotype analysis indicated 
      H1-GTGGGG was linked to a reduced CH risk.
FAU - Fan, Zhiliang
AU  - Fan Z
AD  - Department of Neurology, Chinese People's Liberation Army General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
AD  - The third department of Neurology, Affiliated Xingtai People's Hospital of Hebei 
      Medical University, Xingtai, Hebei Province, 054000, China.
FAU - Hou, Lei
AU  - Hou L
AD  - Department of Neurology, Chinese People's Liberation Army General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
FAU - Wan, Dongjun
AU  - Wan D
AD  - Department of Neurology, Chinese People's Liberation Army General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
FAU - Ao, Ran
AU  - Ao R
AD  - Department of Neurology, Chinese People's Liberation Army General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
FAU - Zhao, Dengfa
AU  - Zhao D
AD  - Department of Neurology, Chinese People's Liberation Army General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
FAU - Yu, Shengyuan
AU  - Yu S
AUID- ORCID: 0000-0002-3961-2464
AD  - Department of Neurology, Chinese People's Liberation Army General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China. yusy1963@126.com.
LA  - eng
GR  - 81671077,81471147/National Natural Science Foundation of China (CN)/
PT  - Journal Article
DEP - 20180109
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
RN  - 0 (HCRTR2 protein, human)
RN  - 0 (Orexin Receptors)
RN  - EC 1.1.1.1 (Alcohol Dehydrogenase)
RN  - EC 1.1.1.1 (alcohol dehydrogenase IV)
RN  - EC 2.3.1.48 (CLOCK Proteins)
RN  - EC 2.3.1.48 (CLOCK protein, human)
SB  - IM
MH  - Adult
MH  - Alcohol Dehydrogenase/*genetics
MH  - CLOCK Proteins/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Cluster Headache/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Orexin Receptors/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Young Adult
PMC - PMC5760492
OTO - NOTNLM
OT  - ADH4
OT  - Clock
OT  - Cluster headache
OT  - Gene polymorphism
OT  - HCRTR2
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The present study was approved by the 
      Ethics Committees of the Chinese PLA General Hospital. Written informed consent 
      was received from patients. CONSENT FOR PUBLICATION: Not applicable. COMPETING 
      INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S 
      NOTE: Springer Nature remains neutral with regard to jurisdictional claims in 
      published maps and institutional affiliations.
EDAT- 2018/01/11 06:00
MHDA- 2018/06/27 06:00
PMCR- 2018/01/09
CRDT- 2018/01/11 06:00
PHST- 2017/11/10 00:00 [received]
PHST- 2017/12/26 00:00 [accepted]
PHST- 2018/01/11 06:00 [entrez]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/06/27 06:00 [medline]
PHST- 2018/01/09 00:00 [pmc-release]
AID - 10.1186/s10194-017-0831-1 [pii]
AID - 831 [pii]
AID - 10.1186/s10194-017-0831-1 [doi]
PST - epublish
SO  - J Headache Pain. 2018 Jan 9;19(1):1. doi: 10.1186/s10194-017-0831-1.