PMID- 29318791
OWN - NLM
STAT- MEDLINE
DCOM- 20180731
LR  - 20221207
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 33
IP  - 4
DP  - 2018 Jan 22
TI  - Impact of Balloon Pulmonary Angioplasty on Hemodynamics and Clinical Outcomes in 
      Patients with Chronic Thromboembolic Pulmonary Hypertension: the Initial Korean 
      Experience.
PG  - e24
LID - 10.3346/jkms.2018.33.e24 [doi]
LID - e24
AB  - BACKGROUND: The treatment of choice for chronic thromboembolic pulmonary 
      hypertension (CTEPH) is pulmonary endarterectomy (PEA). However, not all patients 
      are eligible for PEA, and some patients experience recurrence of pulmonary 
      hypertension even after PEA. METHODS: Patients who underwent balloon pulmonary 
      angioplasty (BPA) between December 2015 and April 2017 were enrolled from the 
      Samsung Medical Center CTEPH registry. Enrolled patients underwent right heart 
      catheterization, echocardiography, and 6-minute walk distance (6MWD) at baseline, 
      4 and 24 weeks after their first BPA session. We compared clinical and 
      hemodynamic parameters at the baseline and last BPA session. RESULTS: Fifty-two 
      BPA sessions were performed in 15 patients, six of whom had a history of PEA. BPA 
      resulted in improvements in World Health Organization (WHO) functional class (2.9 
      +/- 0.8 to 1.7 +/- 0.6, P = 0.002), 6MWD (387.0 +/- 86.4 to 453.4 +/- 64.8 m, P = 0.01), 
      tricuspid annular plane systolic excursion (14.1 +/- 3.6 to 15.6 +/- 4.3 mm, P = 
      0.03) and hemodynamics, including a decline in mean pulmonary artery pressure 
      (41.1 +/- 13.1 to 32.1 +/- 9.5 mmHg, P < 0.001) and in pulmonary vascular resistance 
      (607.4 +/- 452.3 to 406.7 +/- 265.4 dyne.sec.cm(-)(5), P = 0.01) but not in cardiac index 
      (2.94 +/- 0.79 to 2.96 +/- 0.93 L/min/m(2), P = 0.92). Six cases of complications were 
      recorded, including two cases of reperfusion injury. CONCLUSION: BPA might be a 
      safe and effective treatment strategy for both inoperable CTEPH patients and 
      patients with residual pulmonary hypertension after PEA.
CI  - (c) 2018 The Korean Academy of Medical Sciences.
FAU - Kwon, Woochan
AU  - Kwon W
AUID- ORCID: 0000-0002-3963-3142
AD  - Department of Cardiology, Heart Vascular Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Yang, Jeong Hoon
AU  - Yang JH
AUID- ORCID: 0000-0001-8138-1367
AD  - Department of Cardiology, Heart Vascular Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
AD  - Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan 
      University School of Medicine, Seoul, Korea. jhysmc@gmail.com.
FAU - Park, Taek Kyu
AU  - Park TK
AUID- ORCID: 0000-0003-1440-3583
AD  - Department of Cardiology, Heart Vascular Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Chang, Sung A
AU  - Chang SA
AUID- ORCID: 0000-0001-5124-605X
AD  - Department of Cardiology, Heart Vascular Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Jung, Dong Seop
AU  - Jung DS
AUID- ORCID: 0000-0002-6947-8403
AD  - Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Cho, Young Seok
AU  - Cho YS
AUID- ORCID: 0000-0003-1396-4952
AD  - Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Kim, Sung Mok
AU  - Kim SM
AUID- ORCID: 0000-0001-5190-2328
AD  - Department of Radiology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Kim, Tae Jung
AU  - Kim TJ
AUID- ORCID: 0000-0003-2429-3533
AD  - Department of Radiology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Park, Hye Yoon
AU  - Park HY
AUID- ORCID: 0000-0002-5937-9671
AD  - Department of Pulmonary and Critical Care Medicine, Samsung Medical Center, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Choi, Seung Hyuk
AU  - Choi SH
AUID- ORCID: 0000-0002-0304-6317
AD  - Department of Cardiology, Heart Vascular Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Kim, Duk Kyung
AU  - Kim DK
AUID- ORCID: 0000-0001-9227-4196
AD  - Department of Cardiology, Heart Vascular Stroke Institute, Samsung Medical 
      Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20180122
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiography
MH  - *Angioplasty, Balloon/adverse effects
MH  - Asian People
MH  - Blood Pressure
MH  - Chronic Disease
MH  - Echocardiography
MH  - Endarterectomy
MH  - Female
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Hypertension, Pulmonary/complications/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Artery/physiology/surgery
MH  - Pulmonary Embolism/complications/*therapy
MH  - Reperfusion Injury/etiology
MH  - Republic of Korea
MH  - Treatment Outcome
PMC - PMC5760809
OTO - NOTNLM
OT  - Balloon Pulmonary Angioplasty
OT  - Chronic Thromboembolic Pulmonary Hypertension
OT  - Pulmonary Endarterectomy
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2018/01/11 06:00
MHDA- 2018/08/01 06:00
PMCR- 2018/01/22
CRDT- 2018/01/11 06:00
PHST- 2017/07/27 00:00 [received]
PHST- 2017/10/28 00:00 [accepted]
PHST- 2018/01/11 06:00 [entrez]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/08/01 06:00 [medline]
PHST- 2018/01/22 00:00 [pmc-release]
AID - 33.e24 [pii]
AID - 10.3346/jkms.2018.33.e24 [doi]
PST - epublish
SO  - J Korean Med Sci. 2018 Jan 22;33(4):e24. doi: 10.3346/jkms.2018.33.e24.