PMID- 29319810
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181217
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 103
IP  - 4
DP  - 2018 Apr 1
TI  - The Second Phase of Insulin Secretion in Nondiabetic Islet-Grafted Recipients Is 
      Altered and Can Predict Graft Outcome.
PG  - 1310-1319
LID - 10.1210/jc.2017-01342 [doi]
AB  - CONTEXT: Islet transplantation (IT) can treat patients with severely unstable 
      type 1 diabetes. Prehepatic kinetics of insulin secretion (ISec) in two phases 
      can be calculated by C-peptide levels during meal tests. We proposed to describe 
      the ISec profile after a mixed-meal tolerance test (MMTT) in IT recipients and to 
      determine whether the calculated ISec indexes can predict graft outcome. METHODS: 
      We analyzed 34 MMTT among 11 patients who underwent IT between 2011 and 2016 and 
      compared them with healthy controls and patients with type 2 diabetes (T2D). ISec 
      indexes and insulin sensitivity were calculated from models of Van Cauter, Breda, 
      and Mari after MMTT. Graft success was defined by total insulin independence 
      without any criteria for diabetes. RESULTS: In patients with successful IT, the 
      first- and second-phase ISec indexes were lower than those of controls (P < 
      0.001) and did not differ from those of the T2D group. Nevertheless, insulin 
      sensitivity of IT recipients was similar to that of the control group and higher 
      than that of the T2D group. The index of the second phase of ISec ɸS was 
      correlated with total infused islet equivalents (IEQs), was a good predictor of 
      diabetes (re)occurrence, and allowed us to calculate 9500 IEQ/kg as the minimum 
      needed to reach insulin independence. CONCLUSION: We showed that indexes from the 
      first and second phases of ISec are altered in insulin-independent IT recipients. 
      Higher sensitivity distinguishes them from patients with T2D. Even in 
      insulin-independent patients, IT remains a marginal mass model. Moreover, ɸS can 
      estimate transplanted islet mass and predict IT recipient outcomes.
FAU - Villard, Orianne
AU  - Villard O
AD  - Laboratory of Cell Therapy for Diabetes, Institute of Regenerative Medicine and 
      Biotherapy, University Hospital of Montpellier, Saint Eloi Hospital, Montpellier, 
      France.
AD  - Institut National de la Sante et de la Recherche Medicale U1191, Institute of 
      Functional Genomics, Centre National de la Recherche Scientifique, Unite Mixte de 
      Recherche 5203, Montpellier University, Montpellier, France.
FAU - Brun, Jean Frederic
AU  - Brun JF
AD  - Unite Mixte de Recherche, Centre National de la Recherche Scientifique 9214, 
      Institut National de la Sante et de la Recherche Medicale U1046, Physiologie et 
      Medecine Experimentale du coeur et des muscles, Montpellier University, 
      Montpellier, France.
AD  - Department of Clinical Physiology, Metabolic Explorations, University Hospital of 
      Montpellier, Montpellier, France.
FAU - Bories, Lisa
AU  - Bories L
AD  - Department of Endocrinology, Diabetes and Nutrition, University Hospital of 
      Montpellier, Lapeyronie Hospital, Montpellier, France.
FAU - Molinari, Nicolas
AU  - Molinari N
AD  - Department of Medical Information, University Hospital of Montpellier, La 
      Colombiere Hospital, Montpellier, France.
FAU - Benhamou, Pierre Yves
AU  - Benhamou PY
AD  - Department of Diabetology, Pole DigiDune, Grenoble University Hospital, Grenoble 
      Alpes University, Grenoble, France.
AD  - Grenoble Alpes University, Institut National de la Sante et de la Recherche 
      Medicale U1055, Laboratory of Fundamental and Applied Bioenergetics, Grenoble, 
      France.
FAU - Berney, Thierry
AU  - Berney T
AD  - Visceral and Transplant Surgery, Department of Surgery, Geneva University 
      Hospitals and Faculty of Medicine, Geneva, Switzerland.
FAU - Wojtusciszyn, Anne
AU  - Wojtusciszyn A
AD  - Laboratory of Cell Therapy for Diabetes, Institute of Regenerative Medicine and 
      Biotherapy, University Hospital of Montpellier, Saint Eloi Hospital, Montpellier, 
      France.
AD  - Institut National de la Sante et de la Recherche Medicale U1191, Institute of 
      Functional Genomics, Centre National de la Recherche Scientifique, Unite Mixte de 
      Recherche 5203, Montpellier University, Montpellier, France.
AD  - Department of Endocrinology, Diabetes and Nutrition, University Hospital of 
      Montpellier, Lapeyronie Hospital, Montpellier, France.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 1/blood/*surgery
MH  - Diabetes Mellitus, Type 2/blood
MH  - Diagnostic Techniques, Endocrine
MH  - Female
MH  - Humans
MH  - Insulin/blood/*metabolism
MH  - Insulin Secretion
MH  - *Islets of Langerhans Transplantation
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prognosis
MH  - Treatment Outcome
EDAT- 2018/01/11 06:00
MHDA- 2018/10/10 06:00
CRDT- 2018/01/11 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2018/01/03 00:00 [accepted]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2018/01/11 06:00 [entrez]
AID - 4792931 [pii]
AID - 10.1210/jc.2017-01342 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2018 Apr 1;103(4):1310-1319. doi: 10.1210/jc.2017-01342.