PMID- 29320718
OWN - NLM
STAT- MEDLINE
DCOM- 20180601
LR  - 20190318
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 137
DP  - 2018 Mar
TI  - Adiposity and family history of type 2 diabetes in an admixed population of 
      adolescents: Associations with insulin sensitivity, beta-cell function, and 
      hepatic insulin extraction in BRAMS study.
PG  - 72-82
LID - S0168-8227(17)31413-4 [pii]
LID - 10.1016/j.diabres.2017.12.013 [doi]
AB  - AIMS: Insulin resistance and beta-cell dysfunction manifest differently across 
      racial/ethnic groups, and there is a lack of knowledge regarding the 
      pathophysiology of type 2 diabetes mellitus (T2DM) for ethnically admixed 
      adolescents. This study aimed to investigate the influence of adiposity and 
      family history (FH) of T2DM on aspects of insulin sensitivity, beta-cell 
      function, and hepatic insulin extraction in Brazilian adolescents. METHODS: A 
      total of 82 normoglycemic adolescents were assessed. The positive FH of T2DM was 
      defined as the presence of at least one known family member with T2DM. The 
      hyperglycemic clamp test consisted of a 120-min protocol. Insulin secretion and 
      beta-cell function were obtained from C-peptide deconvolution. Analysis of 
      covariance considered pubertal stage as a covariate. RESULTS: Both lean and 
      overweight/obese adolescents had similar glycemic profiles and disposition 
      indexes. Overweight/obese adolescents had about 1/3 the insulin sensitivity of 
      lean adolescents (1.1 +/- 0.2 vs. 3.4 +/- 0.3 mg.kg.min.pmol  * 1000), which was 
      compensated by an increase around 2.5 times in basal (130 +/- 7 vs. 
      52 +/- 10 pmol.l.min) and total insulin secretion (130,091 +/- 12,230 vs. 
      59,010 +/- 17,522 pmol.l.min), and in the first and second phases of insulin 
      secretion; respectively (p < 0.001). This increase was accompanied by a mean 
      reduction in hepatic insulin extraction of 35%, and a 2.7-time increase in 
      beta-cell glucose sensitivity (p < 0.05). The positive FH of T2DM was not 
      associated with derangements in insulin sensitivity, beta-cell function, and 
      hepatic insulin extraction. CONCLUSIONS: In an admixed sample of adolescents, the 
      hyperglycemic clamp test demonstrated that adiposity had a strong influence, and 
      FH of T2DM had no direct influence, in different aspects of glucose metabolism.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Camilo, Daniella F
AU  - Camilo DF
AD  - Laboratory of Investigation on Metabolism and Diabetes (Limed), 
      Gastroenterological Diagnosis and Research Center (Gastrocentro), University of 
      Campinas (Unicamp), Campinas, Sao Paulo, Brazil; Postgraduate Program in Child 
      and Adolescent Health, Faculty of Medical Science, University of Campinas, 
      (Unicamp), Campinas, Sao Paulo, Brazil.
FAU - Vasques, Ana Carolina J
AU  - Vasques ACJ
AD  - Laboratory of Investigation on Metabolism and Diabetes (Limed), 
      Gastroenterological Diagnosis and Research Center (Gastrocentro), University of 
      Campinas (Unicamp), Campinas, Sao Paulo, Brazil; Postgraduate Program in Child 
      and Adolescent Health, Faculty of Medical Science, University of Campinas, 
      (Unicamp), Campinas, Sao Paulo, Brazil; School of Applied Sciences, University of 
      Campinas, Limeira, Sao Paulo, Brazil.
FAU - Hayashi, Keila
AU  - Hayashi K
AD  - Laboratory of Investigation on Metabolism and Diabetes (Limed), 
      Gastroenterological Diagnosis and Research Center (Gastrocentro), University of 
      Campinas (Unicamp), Campinas, Sao Paulo, Brazil; Postgraduate Program in Child 
      and Adolescent Health, Faculty of Medical Science, University of Campinas, 
      (Unicamp), Campinas, Sao Paulo, Brazil.
FAU - Tura, Andrea
AU  - Tura A
AD  - Metabolic Unit, CNR Institute of Neuroscience, Padova, Italy.
FAU - da Silva, Cleliani de Cassia
AU  - da Silva CC
AD  - Laboratory of Investigation on Metabolism and Diabetes (Limed), 
      Gastroenterological Diagnosis and Research Center (Gastrocentro), University of 
      Campinas (Unicamp), Campinas, Sao Paulo, Brazil; Postgraduate Program in Child 
      and Adolescent Health, Faculty of Medical Science, University of Campinas, 
      (Unicamp), Campinas, Sao Paulo, Brazil.
FAU - Zambon, Mariana P
AU  - Zambon MP
AD  - Postgraduate Program in Child and Adolescent Health, Faculty of Medical Science, 
      University of Campinas, (Unicamp), Campinas, Sao Paulo, Brazil; Department of 
      Pediatrics, University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil.
FAU - Antonio, Maria Angela R de G Monteiro
AU  - Antonio MARGM
AD  - Postgraduate Program in Child and Adolescent Health, Faculty of Medical Science, 
      University of Campinas, (Unicamp), Campinas, Sao Paulo, Brazil; Department of 
      Pediatrics, University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil.
FAU - Geloneze, Bruno
AU  - Geloneze B
AD  - Laboratory of Investigation on Metabolism and Diabetes (Limed), 
      Gastroenterological Diagnosis and Research Center (Gastrocentro), University of 
      Campinas (Unicamp), Campinas, Sao Paulo, Brazil; Postgraduate Program in Child 
      and Adolescent Health, Faculty of Medical Science, University of Campinas, 
      (Unicamp), Campinas, Sao Paulo, Brazil; National Institute of Science and 
      Technology of Obesity and Diabetes, Brazil. Electronic address: 
      bgeloneze@terra.com.br.
LA  - eng
PT  - Journal Article
DEP - 20180107
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Insulin)
SB  - IM
MH  - Adiposity/*physiology
MH  - Adolescent
MH  - Child
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*etiology/pathology
MH  - Female
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Resistance/*physiology
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/*physiology
MH  - Male
MH  - Obesity/*complications
OTO - NOTNLM
OT  - Adolescents
OT  - Heredity
OT  - Hyperglycemic clamp
OT  - Insulin secretion in vivo
OT  - Insulin sensitivity
OT  - Obesity
EDAT- 2018/01/11 06:00
MHDA- 2018/06/02 06:00
CRDT- 2018/01/11 06:00
PHST- 2017/08/30 00:00 [received]
PHST- 2017/11/15 00:00 [revised]
PHST- 2017/12/18 00:00 [accepted]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/06/02 06:00 [medline]
PHST- 2018/01/11 06:00 [entrez]
AID - S0168-8227(17)31413-4 [pii]
AID - 10.1016/j.diabres.2017.12.013 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Mar;137:72-82. doi: 10.1016/j.diabres.2017.12.013. 
      Epub 2018 Jan 7.