PMID- 29320807
OWN - NLM
STAT- MEDLINE
DCOM- 20181114
LR  - 20181114
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 23
IP  - 6
DP  - 2018 Jun
TI  - Overlap of interstitial pneumonia with autoimmune features with undifferentiated 
      connective tissue disease and contribution of UIP to mortality.
PG  - 600-605
LID - 10.1111/resp.13254 [doi]
AB  - BACKGROUND AND OBJECTIVE: Criteria for interstitial pneumonia with autoimmune 
      features (IPAF) were recently established for research purposes in a joint 
      statement from the European Respiratory Society (ERS) and American Thoracic 
      Society (ATS). We reviewed the utility of these criteria in patients previously 
      diagnosed as broadly defined undifferentiated connective tissue disease (UCTD) 
      and noted overlapping IPAF findings. Additional review was given to IPAF patients 
      with usual interstitial pneumonia (UIP) on histopathology or radiology in terms 
      of survival and outcome. METHODS: Patients with prior UCTD-interstitial lung 
      disease (ILD) were screened by ERS/ATS criteria for IPAF. Clinical data along 
      with all-cause mortality were collated and compared with selected idiopathic 
      pulmonary fibrosis (IPF) patients from the same study period. Survival was 
      compared between IPAF subgroups with and without UIP features. RESULTS: One 
      hundred and one UCTD-ILD subjects (91%) evaluated from 2005 to 2012 also met 
      strict criteria for IPAF. Frequent clinical findings included Raynaud's 
      phenomenon, positive anti-nuclear antibody (ANA) and non-specific interstitial 
      pneumonia (NSIP) pattern on chest computed tomography (CT). Nineteen had features 
      of UIP either on histopathology or CT imaging. As compared with IPF, IPAF 
      patients had overall better survival except in those with UIP features. 
      CONCLUSION: Current IPAF criteria encompassed the majority of broadly defined 
      UCTD-ILD and included those with UIP findings. Survival compared with IPF in 
      those with UIP was similar. Further studies are necessary to refine IPAF 
      definitions for clinical use and guide directed management strategies.
CI  - (c) 2018 Asian Pacific Society of Respirology.
FAU - Kelly, Bryan T
AU  - Kelly BT
AD  - Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
FAU - Moua, Teng
AU  - Moua T
AUID- ORCID: 0000-0003-3329-5717
AD  - Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20180110
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
SB  - IM
CIN - Respirology. 2018 Oct;23(10):959. PMID: 30070408
CIN - Respirology. 2018 Oct;23(10):958. PMID: 30070755
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoimmune Diseases/*classification/diagnostic imaging/mortality/pathology
MH  - Cause of Death
MH  - Female
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/*classification/diagnostic 
      imaging/mortality/pathology
MH  - Lung/diagnostic imaging/pathology
MH  - Lung Diseases, Interstitial/*classification/diagnostic 
      imaging/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - Tomography, X-Ray Computed/methods
MH  - Undifferentiated Connective Tissue Diseases/*classification/diagnostic 
      imaging/mortality/pathology
MH  - Young Adult
OTO - NOTNLM
OT  - autoimmune disease
OT  - idiopathic pulmonary fibrosis
OT  - interstitial lung disease
OT  - interstitial pneumonia
OT  - usual interstitial pneumonia
EDAT- 2018/01/11 06:00
MHDA- 2018/11/15 06:00
CRDT- 2018/01/11 06:00
PHST- 2017/02/17 00:00 [received]
PHST- 2017/11/22 00:00 [revised]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2018/01/11 06:00 [pubmed]
PHST- 2018/11/15 06:00 [medline]
PHST- 2018/01/11 06:00 [entrez]
AID - 10.1111/resp.13254 [doi]
PST - ppublish
SO  - Respirology. 2018 Jun;23(6):600-605. doi: 10.1111/resp.13254. Epub 2018 Jan 10.