PMID- 29321655
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20190110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Jan 10
TI  - Evaluation of Brain Activity Using Near-infrared Spectroscopy in Inflammatory 
      Bowel Disease Patients.
PG  - 402
LID - 10.1038/s41598-017-18897-4 [doi]
LID - 402
AB  - Depression is implicated as a risk factor for the recurrence of inflammatory 
      bowel disease (IBD). Near-infrared spectroscopy (NIRS) and brain-derived 
      neurotrophic factor (BDNF) are useful tools for evaluation of brain activity and 
      a depressive state, respectively. The aim of this study was to clarify the 
      association between brain activity or depressive symptoms and IBD using NIRS and 
      BDNF. This study included 36 ulcerative colitis (UC) patients, 32 Crohn's disease 
      (CD) patients, and 17 healthy controls (HC). Center for Epidemiologic Studies 
      Depression Scale (CES-D) scores were determined, NIRS was performed, and serum 
      BDNF levels were measured in all subjects. NIRS showed that the mean oxygenated 
      hemoglobin concentration was significantly lower in the frontal lobe in the UC 
      group than in the HC group (HC 167 +/- 106 vs. UC 83.1 +/- 85.3, p < 0.05). No 
      significant difference was seen between the HC and CD groups. There were also no 
      significant differences in CED-D scores and BDNF levels among the groups. Changes 
      in the NIRS values of the UC group may indicate decreased brain activity and a 
      fundamental difference between UC and CD, which are often lumped together as two 
      types of IBD.
FAU - Fujiwara, Tatsuo
AU  - Fujiwara T
AD  - Departments of Gastroenterology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan. tafuji@fmu.ac.jp.
FAU - Kono, Soichi
AU  - Kono S
AD  - Departments of Neuropsychiatry, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Katakura, Kyoko
AU  - Katakura K
AD  - Departments of Gastroenterology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Abe, Kazumichi
AU  - Abe K
AD  - Departments of Gastroenterology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Takahashi, Atsushi
AU  - Takahashi A
AUID- ORCID: 0000-0003-0568-8361
AD  - Departments of Gastroenterology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Gunji, Naohiko
AU  - Gunji N
AD  - Departments of Gastroenterology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Yokokawa, Aki
AU  - Yokokawa A
AD  - Departments of Gastroenterology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Kawashima, Kazumasa
AU  - Kawashima K
AD  - Departments of Gastroenterology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Suzuki, Rieko
AU  - Suzuki R
AD  - Departments of Neuropsychiatry, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Wada, Akira
AU  - Wada A
AD  - Departments of Neuropsychiatry, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
AD  - Department of Neuropsychiatry, The University of Tokyo Hospital, Tokyo, Japan.
FAU - Miura, Itaru
AU  - Miura I
AD  - Departments of Neuropsychiatry, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Yabe, Hirooki
AU  - Yabe H
AD  - Departments of Neuropsychiatry, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Ohira, Hiromasa
AU  - Ohira H
AD  - Departments of Gastroenterology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180110
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain/*diagnostic imaging
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Case-Control Studies
MH  - Colitis, Ulcerative/blood/diagnostic imaging/*psychology
MH  - Crohn Disease/blood/diagnostic imaging/*psychology
MH  - Depression/blood/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Spectroscopy, Near-Infrared/*methods
MH  - Young Adult
PMC - PMC5762642
COIS- The authors declare that they have no competing interests.
EDAT- 2018/01/13 06:00
MHDA- 2018/11/21 06:00
PMCR- 2018/01/10
CRDT- 2018/01/12 06:00
PHST- 2017/06/28 00:00 [received]
PHST- 2017/12/18 00:00 [accepted]
PHST- 2018/01/12 06:00 [entrez]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
PHST- 2018/01/10 00:00 [pmc-release]
AID - 10.1038/s41598-017-18897-4 [pii]
AID - 18897 [pii]
AID - 10.1038/s41598-017-18897-4 [doi]
PST - epublish
SO  - Sci Rep. 2018 Jan 10;8(1):402. doi: 10.1038/s41598-017-18897-4.