PMID- 29321710
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1300-0667 (Print)
IS  - 1309-4866 (Electronic)
IS  - 1300-0667 (Linking)
VI  - 54
IP  - 4
DP  - 2017 Dec
TI  - Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy 
      Related to Hippocampal Sclerosis.
PG  - 350-353
LID - 10.5152/npa.2016.12678 [doi]
AB  - OBJECTIVE: Hippocampal sclerosis (HS) is the most common pathological substrate 
      associated with mesial temporal lobe epilepsy (MTLE), where inflammatory 
      processes are known to play an increasingly important role in the pathogenesis. 
      To further investigate the role of the immune system, both cytokine gene 
      polymorphisms and human leukocyte antigen (HLA) genotyping in patients with 
      MTLE-HS were investigated. METHODS: The DNA samples of 100 patients with MTLE-HS 
      and 201 healthy individuals were genotyped for cytokines (IL-6,IL-10, TNF-alpha, 
      TGF-beta1 and IFN-gamma) and HLA using polymerase chain reaction (PCR)-SSP and SSO 
      methods. The results were statistically analyzed in patient and healthy control 
      groups and then according to the presence of febrile seizures (FS) in the patient 
      group. RESULTS: Analysis of cytokine genotyping did not reveal any significant 
      difference between patients with MTLE-HS and controls and patients with or 
      without FS. However, the HLA DRB1*13 allele was found to be more frequent in the 
      patient population after Bonferroni correction. CONCLUSION: This study suggests 
      the possible role of HLA in the pathogenesis of MTLE-HS, although it failed to 
      show any relationship with the cytokine system. However, data regarding the role 
      of HLA are still lacking, and further studies are necessary to verify our 
      results.
FAU - Altintas, Ayse
AU  - Altintas A
AD  - Department of Neurology, Istanbul University Cerrahpasa School of Medicine, 
      Istanbul, Turkey.
FAU - Ozkara, Cigdem
AU  - Ozkara C
AD  - Department of Neurology, Istanbul University Cerrahpasa School of Medicine, 
      Istanbul, Turkey.
FAU - Sohtaoglu Sevindik, Melis
AU  - Sohtaoglu Sevindik M
AD  - Department of Neurology, Istanbul University Cerrahpasa School of Medicine, 
      Istanbul, Turkey.
FAU - Uzan, Mustafa
AU  - Uzan M
AD  - Department of Neurosurgery, Istanbul University Cerrahpasa School of Medicine, 
      Istanbul, Turkey.
FAU - Kekik Cinar, Cigdem
AU  - Kekik Cinar C
AD  - Department of Medical Biology, Istanbul University Istanbul School of Medicine, 
      Istanbul, Turkey.
FAU - Uysal, Omer
AU  - Uysal O
AD  - Department of Biostatistics and Medicine Informatics, Bezmialem Vakif University 
      School of Medicine, Istanbul, Turkey.
FAU - Savran Oguz, Fatma
AU  - Savran Oguz F
AD  - Department of Medical Biology, Istanbul University Istanbul School of Medicine, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160715
PL  - Turkey
TA  - Noro Psikiyatr Ars
JT  - Noro psikiyatri arsivi
JID - 9426194
PMC - PMC5758080
OTO - NOTNLM
OT  - HLA genotyping
OT  - Temporal lobe epilepsy
OT  - cytokine expression
OT  - hippocampal sclerosis
COIS- Conflict of Interest: No conflict of interest was declared by the authors.
EDAT- 2018/01/13 06:00
MHDA- 2018/01/13 06:01
PMCR- 2017/12/01
CRDT- 2018/01/12 06:00
PHST- 2015/12/29 00:00 [received]
PHST- 2016/04/10 00:00 [accepted]
PHST- 2018/01/12 06:00 [entrez]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/01/13 06:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - npa-54-4-350 [pii]
AID - 10.5152/npa.2016.12678 [doi]
PST - ppublish
SO  - Noro Psikiyatr Ars. 2017 Dec;54(4):350-353. doi: 10.5152/npa.2016.12678. Epub 
      2016 Jul 15.