PMID- 29322431
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2193-8210 (Print)
IS  - 2190-9172 (Electronic)
VI  - 8
IP  - 1
DP  - 2018 Mar
TI  - Daylight Photodynamic Therapy Versus 5-Fluorouracil for the Treatment of Actinic 
      Keratosis: A Case Series.
PG  - 137-141
LID - 10.1007/s13555-017-0219-9 [doi]
AB  - INTRODUCTION: The incidence of actinic keratosis (AK) continues to increase 
      worldwide. Currently available options for the treatment of AK include topical 
      5-fluorouracil (5-FU) and daylight-mediated photodynamic therapy (DL-PDT). This 
      split-face pilot study compared DL-PDT using 16% methyl aminolevulinate (MAL) 
      cream versus 5-FU cream in patients with AK on the face/scalp. METHODS: Five male 
      subjects (mean age 70 years) with grade I-III AK on the face/scalp were enrolled. 
      Subjects received a single session of DL-PDT with 16% MAL on one side and topical 
      5% 5-FU for 21 days on the other side. Evaluations of efficacy, safety, and 
      subject satisfaction were conducted 48 h, 7 days, 14 days, 1 month, and 3 months 
      after treatment. RESULTS: At 3 months, the lesion complete response rate was 80% 
      and 93% for DL-PDT and 5-FU, respectively. Lesion partial response was 20% and 
      7%, respectively. Fewer treatment-related adverse events (AEs) were reported with 
      DL-PDT than with 5-FU, and they resolved spontaneously in 5-7 and 27-30 days, 
      respectively. Subjects preferred DL-PDT because of the lower incidence of AEs and 
      rapid recovery compared with 5-FU. CONCLUSION: DL-PDT is a convenient alternative 
      to 5-FU with good efficacy and a favorable safety profile, allowing patients to 
      effectively treat their AK without compromising their social life. FUNDING: 
      Galderma.
FAU - Galimberti, Gaston Nestor
AU  - Galimberti GN
AUID- ORCID: 0000-0003-3537-9148
AD  - Department of Dermatology, School of Medicine, Hospital Italiano de Buenos Aires, 
      Buenos Aires, Argentina. gaston.galimberti@gmail.com.
LA  - eng
GR  - N/A/Galderma/
PT  - Journal Article
DEP - 20180110
PL  - Switzerland
TA  - Dermatol Ther (Heidelb)
JT  - Dermatology and therapy
JID - 101590450
PMC - PMC5825324
OTO - NOTNLM
OT  - 5-Fluorouracil
OT  - Cancerization field
OT  - Daylight-mediated photodynamic therapy
OT  - Methyl aminolevulinate
OT  - Photodamage
EDAT- 2018/01/13 06:00
MHDA- 2018/01/13 06:01
PMCR- 2018/01/10
CRDT- 2018/01/12 06:00
PHST- 2017/11/23 00:00 [received]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/01/13 06:01 [medline]
PHST- 2018/01/12 06:00 [entrez]
PHST- 2018/01/10 00:00 [pmc-release]
AID - 10.1007/s13555-017-0219-9 [pii]
AID - 219 [pii]
AID - 10.1007/s13555-017-0219-9 [doi]
PST - ppublish
SO  - Dermatol Ther (Heidelb). 2018 Mar;8(1):137-141. doi: 10.1007/s13555-017-0219-9. 
      Epub 2018 Jan 10.