PMID- 29325339
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20181202
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 97
IP  - 48
DP  - 2017 Dec 26
TI  - [Risk factors and impacts on prognosis of ultrasound lung comets in patients 
      undergoing hemodialysis].
PG  - 3796-3801
LID - 10.3760/cma.j.issn.0376-2491.2017.48.009 [doi]
AB  - Objective: To investigate the risk factors of ultrasound lung comets and its 
      impact on the survivals of patients undergoing hemodialysis. Methods: One hundred 
      and forty-two patients on hemodialysis (Male 76, female 66) were divided into 
      three groups according to the score of lung comets (mild: </=14 comets; moderate: 
      15 to 30 comets; severe: >30 comets). Seventy-two healthy subjects examined by 
      lung ultrasound serve as a control. Pulmonary artery systolic pressure and left 
      ventricular ejection fraction (LVEF) were assessed by Doppler ultrasonography. 
      High-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor (TNF)-alpha 
      were measured by the automatic analyzer and enzyme-linked immunosorbent assay. 
      Results: With the increasing age of the patients, lung comets scores increased 
      (P<0.05). There were significant differences in TNF-alpha (P<0.05), interdialytic 
      weight gain (IDWG) (P<0.05), pulmonary artery systolic pressure and LVEF (P<0.05) 
      among three groups. In multivariate linear regression, the lung comets score was 
      positively related to multiple clinical variables including New York Heart 
      Association (NYHA) classification (P=0.023), hsCRP (P=0.042), TNF-alpha (P<0.001), 
      IDWG (P=0.031), and pulmonary artery systolic pressure (P<0.001). In the 
      multivariate Cox proportional hazards models, lung comets score was independent 
      risk factor for death (P=0.001). In Kaplan-Meier survival analysis, the risk of 
      all-cause mortality increased in parallel with lung comets score, and patients 
      with lung comets score (>30 comets) were at highest risk of death among all three 
      groups (log-rank test chi(2)=12.73, P=0.001). Conclusion: Lung comets is associated 
      with inflammation, pulmonary artery systolic pressure/volume overload and heart 
      function. Lung comets score represents the alterations of heart function and it 
      may serve as a powerful predictor of all-cause mortality for hemodialysis 
      patients.
FAU - Wang, Z L
AU  - Wang ZL
AD  - Department of Nephrology, Laiwu Municipal People's Hospital, Laiwu 271100, China.
FAU - Liu, J Y
AU  - Liu JY
FAU - Zhou, C J
AU  - Zhou CJ
FAU - Wang, M B
AU  - Wang MB
FAU - Wang, H Y
AU  - Wang HY
FAU - Xu, Y
AU  - Xu Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung/diagnostic imaging/*pathology
MH  - Male
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - *Renal Dialysis
MH  - Risk Factors
MH  - Stroke Volume
MH  - Ultrasonography, Doppler
OTO - NOTNLM
OT  - Hemodialysis
OT  - Lung comets
OT  - Pulmonary edema
OT  - Survival
OT  - Ultrasonography
EDAT- 2018/01/13 06:00
MHDA- 2018/06/30 06:00
CRDT- 2018/01/12 06:00
PHST- 2018/01/12 06:00 [entrez]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2017.48.009 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2017 Dec 26;97(48):3796-3801. doi: 
      10.3760/cma.j.issn.0376-2491.2017.48.009.