PMID- 29325465
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20190901
IS  - 1471-1753 (Electronic)
IS  - 0954-6634 (Print)
IS  - 0954-6634 (Linking)
VI  - 29
IP  - 6
DP  - 2018 Sep
TI  - Prevalence of positive QuantiFERON gold in-tube testing in hidradenitis 
      suppurativa.
PG  - 637-640
LID - 10.1080/09546634.2018.1425360 [doi]
AB  - AIM: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease 
      of the apocrine sweat glands. Tumor necrosis factor-alpha (TNF-alpha) inhibitors are 
      commonly used to treat HS. However, prior to initiating therapy patients must be 
      screened for mycobacterium tuberculosis (mTB) exposure. Several mTB screening 
      tests based on interferon gamma release assays are commercially available, but 
      the performance of these assays in the HS population is unknown. The purpose of 
      this study was to investigate the performance of the QuantiFERON gold in-tube 
      assay (QFT-GIT) in a cohort of patients with HS. METHODS: This prospective study 
      was conducted through the Wound Etiology and Healing (WE-HEAL) study. QFTGIT 
      testing was performed using a commercial laboratory. Patients with positive test 
      results underwent follow-up testing to evaluate for latent tuberculosis infection 
      (LTBI). Data were collected on demographics and disease activity scores including 
      Hurley stage, HS Sartorius score (HSS) and active nodule (AN) count. RESULTS: Of 
      the 69 patients with a confirmed diagnosis of HS, seven (10.1%) tested QFT-GIT 
      positive and 5.8% were diagnosed with LTBI. CONCLUSIONS: QFT-GIT results did not 
      correlate with demographic characteristics or HS disease activity.
FAU - Boortalary, Tina
AU  - Boortalary T
AD  - a Division of Rheumatology, Ideas to Health Laboratory , The George Washington 
      University, School of Medicine and Health Sciences , Washington , DC , USA.
FAU - Misra, Kanchan
AU  - Misra K
AD  - a Division of Rheumatology, Ideas to Health Laboratory , The George Washington 
      University, School of Medicine and Health Sciences , Washington , DC , USA.
FAU - McNish, Sean
AU  - McNish S
AD  - a Division of Rheumatology, Ideas to Health Laboratory , The George Washington 
      University, School of Medicine and Health Sciences , Washington , DC , USA.
FAU - Jones, Derek
AU  - Jones D
AD  - a Division of Rheumatology, Ideas to Health Laboratory , The George Washington 
      University, School of Medicine and Health Sciences , Washington , DC , USA.
FAU - Shanmugam, Victoria K
AU  - Shanmugam VK
AUID- ORCID: 0000-0002-5882-4884
AD  - a Division of Rheumatology, Ideas to Health Laboratory , The George Washington 
      University, School of Medicine and Health Sciences , Washington , DC , USA.
LA  - eng
GR  - R01 NR013888/NR/NINR NIH HHS/United States
GR  - UL1 TR000075/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20180122
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Reagent Kits, Diagnostic)
SB  - IM
MH  - Adult
MH  - False Positive Reactions
MH  - Female
MH  - Hidradenitis Suppurativa/complications/*diagnosis/pathology
MH  - Humans
MH  - Latent Tuberculosis/complications/*diagnosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Reagent Kits, Diagnostic
MH  - Tuberculin Test/*methods
PMC - PMC6172136
MID - NIHMS1501321
OTO - NOTNLM
OT  - Hidradenitis suppurativa
OT  - QuantiFERON gold
OT  - interferon-gamma
OT  - tumor necrosis factor-alpha
EDAT- 2018/01/13 06:00
MHDA- 2018/09/05 06:00
PMCR- 2019/09/01
CRDT- 2018/01/13 06:00
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
PHST- 2018/01/13 06:00 [entrez]
PHST- 2019/09/01 00:00 [pmc-release]
AID - 10.1080/09546634.2018.1425360 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2018 Sep;29(6):637-640. doi: 10.1080/09546634.2018.1425360. 
      Epub 2018 Jan 22.