PMID- 29326972 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220410 IS - 2352-5789 (Print) IS - 2352-5789 (Electronic) IS - 2352-5789 (Linking) VI - 23 DP - 2018 Feb TI - Aggressive neuroendocrine tumor of the ovary with multiple metastases treated with everolimus: A case report. PG - 20-23 LID - 10.1016/j.gore.2018.01.002 [doi] AB - *Neuroendocrine tumors (NETs) frequently occur in the lungs or the gastrointestinal tract; they are uncommon in the ovary.*The mammalian target of rapamycin (mTOR) pathway has been reported as a treatment for advanced NETs.*We describe a patient with an aggressive primary ovarian NET, successfully treated with everolimus (an mTOR inhibitor). FAU - Kaiho-Sakuma, Michiko AU - Kaiho-Sakuma M AD - Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan. FAU - Toyoshima, Masafumi AU - Toyoshima M AD - Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan. FAU - Watanabe, Mika AU - Watanabe M AD - Department of Pathology, Tohoku University Hospital, Sendai, Japan. FAU - Toki, Asami AU - Toki A AD - Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan. FAU - Kameda, Satomi AU - Kameda S AD - Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan. FAU - Minato, Takamichi AU - Minato T AD - Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan. FAU - Niikura, Hitoshi AU - Niikura H AD - Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan. FAU - Yaegashi, Nobuo AU - Yaegashi N AD - Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, Japan. LA - eng PT - Case Reports DEP - 20180104 PL - Netherlands TA - Gynecol Oncol Rep JT - Gynecologic oncology reports JID - 101652231 PMC - PMC5760241 OTO - NOTNLM OT - BEP, bleomycin, etoposide, and cisplatin OT - CA-125, carbohydrate antigen 125 OT - CD56, cluster of differentiation 56 OT - CDX2, caudal-type homeobox transcription factor 2 OT - CT, computed tomography OT - Carcinoid OT - EMA, epithelial membrane antigen OT - Everolimus OT - FIGO, International Federation of Gynecology and Obstetrics OT - MRI, magnetic resonance imaging OT - Multiple metastases OT - NETs, neuroendocrine tumors OT - Neuroendocrine tumor OT - Ovary OT - mTOR, mammalian target of rapamycin EDAT- 2018/01/13 06:00 MHDA- 2018/01/13 06:01 PMCR- 2018/01/04 CRDT- 2018/01/13 06:00 PHST- 2017/11/29 00:00 [received] PHST- 2018/01/01 00:00 [revised] PHST- 2018/01/03 00:00 [accepted] PHST- 2018/01/13 06:00 [entrez] PHST- 2018/01/13 06:00 [pubmed] PHST- 2018/01/13 06:01 [medline] PHST- 2018/01/04 00:00 [pmc-release] AID - S2352-5789(18)30002-X [pii] AID - 10.1016/j.gore.2018.01.002 [doi] PST - epublish SO - Gynecol Oncol Rep. 2018 Jan 4;23:20-23. doi: 10.1016/j.gore.2018.01.002. eCollection 2018 Feb.