PMID- 29327117
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20181113
IS  - 1749-0774 (Electronic)
IS  - 0914-7470 (Print)
IS  - 0914-7470 (Linking)
VI  - 31
IP  - 2
DP  - 2018 Apr
TI  - Graphical classification of DNA sequences of HLA alleles by deep learning.
PG  - 102-105
LID - 10.1007/s13577-017-0194-6 [doi]
AB  - Alleles of human leukocyte antigen (HLA)-A DNAs are classified and expressed 
      graphically by using artificial intelligence "Deep Learning (Stacked 
      autoencoder)". Nucleotide sequence data corresponding to the length of 822 bp, 
      collected from the Immuno Polymorphism Database, were compressed to 2-dimensional 
      representation and were plotted. Profiles of the two-dimensional plots indicate 
      that the alleles can be classified as clusters are formed. The two-dimensional 
      plot of HLA-A DNAs gives a clear outlook for characterizing the various alleles.
FAU - Miyake, Jun
AU  - Miyake J
AUID- ORCID: 0000-0002-8155-4894
AD  - Graduate School of Engineering Science, Osaka University, 1-3 Machikane-Yama, 
      Toyonaka, Osaka, 560-8531, Japan. jun_miyake@bpe.es.osaka-u.ac.jp.
AD  - Global Center for Medical Engineering and Informatics, Osaka University, Building 
      A-301, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan. 
      jun_miyake@bpe.es.osaka-u.ac.jp.
FAU - Kaneshita, Yuhei
AU  - Kaneshita Y
AD  - Graduate School of Engineering Science, Osaka University, 1-3 Machikane-Yama, 
      Toyonaka, Osaka, 560-8531, Japan.
FAU - Asatani, Satoshi
AU  - Asatani S
AD  - Graduate School of Engineering Science, Osaka University, 1-3 Machikane-Yama, 
      Toyonaka, Osaka, 560-8531, Japan.
FAU - Tagawa, Seiichi
AU  - Tagawa S
AD  - Graduate School of Engineering Science, Osaka University, 1-3 Machikane-Yama, 
      Toyonaka, Osaka, 560-8531, Japan.
FAU - Niioka, Hirohiko
AU  - Niioka H
AD  - Graduate School of Engineering Science, Osaka University, 1-3 Machikane-Yama, 
      Toyonaka, Osaka, 560-8531, Japan.
FAU - Hirano, Takashi
AU  - Hirano T
AD  - Graduate School of Engineering Science, Osaka University, 1-3 Machikane-Yama, 
      Toyonaka, Osaka, 560-8531, Japan.
AD  - Okinawa Institute of Advanced Sciences, Uruma, 904-2234, Japan.
AD  - Okinawa Research Institute of Sentan Pharma Co. Ltd., Uruma, Okinawa, 904-2234, 
      Japan.
LA  - eng
GR  - 2306/Ministry of Education, Culture, Sports, Science, and Technology of Japan/
PT  - Journal Article
DEP - 20180111
PL  - Japan
TA  - Hum Cell
JT  - Human cell
JID - 8912329
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - *Alleles
MH  - *Artificial Intelligence
MH  - *Base Sequence
MH  - *Databases, Nucleic Acid
MH  - HLA-A Antigens/*genetics
MH  - Humans
MH  - Sequence Analysis, DNA/*methods
PMC - PMC5852191
OTO - NOTNLM
OT  - Allele
OT  - Artificial intelligence
OT  - Autoencoder
OT  - Deep learning
OT  - HLA
COIS- The authors declare that they have no conflict of interest.
EDAT- 2018/01/13 06:00
MHDA- 2018/06/26 06:00
PMCR- 2018/01/11
CRDT- 2018/01/13 06:00
PHST- 2017/08/26 00:00 [received]
PHST- 2017/11/22 00:00 [accepted]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2018/01/13 06:00 [entrez]
PHST- 2018/01/11 00:00 [pmc-release]
AID - 10.1007/s13577-017-0194-6 [pii]
AID - 194 [pii]
AID - 10.1007/s13577-017-0194-6 [doi]
PST - ppublish
SO  - Hum Cell. 2018 Apr;31(2):102-105. doi: 10.1007/s13577-017-0194-6. Epub 2018 Jan 
      11.