PMID- 29327276
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20181113
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 33
IP  - 7
DP  - 2018 Jul
TI  - Portal congestion and intestinal edema in hospitalized patients with heart 
      failure.
PG  - 740-751
LID - 10.1007/s00380-018-1117-5 [doi]
AB  - An interaction between the intestine and cardiovascular disease has been 
      suggested. We thought to clarify the association between intestinal conditions 
      and clinical outcomes in patients with heart failure (HF). Hemodynamic parameters 
      in intestinal vessels [superior mesenteric artery (SMA), inferior mesenteric 
      artery (IMA), and portal vein (PV)] and average colon wall thickness (aCWT) from 
      the ascending colon to sigmoid colon were evaluated in 224 hospitalized HF 
      patients. Echocardiographic parameters and composite event rates (all-cause 
      mortality, readmission for HF deterioration, major ventricular arrhythmias) were 
      also examined. Higher PV congestion index (CI) and aCWT were observed in patients 
      with New York Heart Association (NYHA) class III/IV. Higher PVCI [hazard ratio 
      (HR) per + 1 standard deviation (SD) 1.50, p < 0.01] and aCWT (HR per + 1 SD 
      1.45, p < 0.01) were independently associated with higher composite event rates 
      during the follow-up of 122 +/- 68 days. None of SMA/IMA hemodynamic parameters 
      were associated with NYHA class or composite event rates. Higher right 
      ventricular end-diastolic dimension (38 +/- 7 vs 34 +/- 9 mm, p < 0.01) and lower 
      tricuspid annual plane systolic excursion (15 +/- 5 vs 19 +/- 5 mm, p < 0.001) were 
      observed in patients with higher PVCI (> 0.031 cm s) and aCWT (> 2.8 mm) relative 
      to those in others. In conclusion, increased portal congestion and intestinal 
      edema were associated with severe HF symptoms and poor outcomes in hospitalized 
      HF patients, in addition to being associated with impaired right-sided cardiac 
      function.
FAU - Ikeda, Yuki
AU  - Ikeda Y
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan. 
      y_ikeda@med.kitasato-u.ac.jp.
FAU - Ishii, Shunsuke
AU  - Ishii S
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Yazaki, Mayu
AU  - Yazaki M
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Fujita, Teppei
AU  - Fujita T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Iida, Yuichiro
AU  - Iida Y
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Kaida, Toyoji
AU  - Kaida T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Nabeta, Takeru
AU  - Nabeta T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Nakatani, Eiji
AU  - Nakatani E
AD  - Translational Research Informatics Center, Foundation for Biomedical Research and 
      Innovation, Kobe, Japan.
FAU - Maekawa, Emi
AU  - Maekawa E
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Yanagisawa, Tomoyoshi
AU  - Yanagisawa T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Koitabashi, Toshimi
AU  - Koitabashi T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
FAU - Inomata, Takayuki
AU  - Inomata T
AD  - Department of Cardiovascular Medicine, Kitasato Institute Hospital, Tokyo, Japan.
FAU - Ako, Junya
AU  - Ako J
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180111
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
SB  - IM
MH  - Aged
MH  - Echocardiography
MH  - Edema/diagnosis/*etiology/physiopathology
MH  - Female
MH  - Heart Failure/*complications/physiopathology/therapy
MH  - Humans
MH  - Hypertension, Portal/*etiology/physiopathology
MH  - *Inpatients
MH  - Intestinal Diseases/diagnosis/*etiology/physiopathology
MH  - Male
MH  - Portal Vein/*physiopathology
MH  - Prognosis
MH  - Prospective Studies
MH  - Stroke Volume
MH  - Ultrasonography
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Congestion
OT  - Heart failure
OT  - Intestinal dysbiosis
OT  - Right ventricular function
EDAT- 2018/01/13 06:00
MHDA- 2018/09/01 06:00
CRDT- 2018/01/13 06:00
PHST- 2017/08/20 00:00 [received]
PHST- 2018/01/05 00:00 [accepted]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2018/01/13 06:00 [entrez]
AID - 10.1007/s00380-018-1117-5 [pii]
AID - 10.1007/s00380-018-1117-5 [doi]
PST - ppublish
SO  - Heart Vessels. 2018 Jul;33(7):740-751. doi: 10.1007/s00380-018-1117-5. Epub 2018 
      Jan 11.