PMID- 29328539
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20190916
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 48
IP  - 2
DP  - 2018 Aug
TI  - Early detection of myocardial involvement by T(1) mapping of cardiac MRI in 
      idiopathic inflammatory myopathy.
PG  - 415-422
LID - 10.1002/jmri.25945 [doi]
AB  - BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are common types of 
      idiopathic inflammatory myopathy (IIM), wherein patients are prone to adverse 
      cardiovascular events. PURPOSE: To explore the value of cardiac magnetic 
      resonance imaging (MRI) for detecting cardiac involvement in PM/DM patients using 
      a T(1) mapping technique. STUDY TYPE: Prospective observational study. 
      POPULATION: In all, 25 PM/DM patients free of cardiovascular symptoms and 
      preserved ventricular systolic function and 25 healthy volunteers matched for age 
      and sex served as controls. FIELD STRENGTH/SEQUENCE: Cardiac MRI at 3T, including 
      steady-state free precession (SSFP) cine imaging, late gadolinium enhancement 
      (LGE), and T(1) mapping with modified Look-Locker inversion recovery (MOLLI). 
      ASSESSMENT: Myocardial native T(1) and extracellular volume (ECV) of the left 
      ventricle as well as the correlations with disease activity were analyzed. 
      STATISTICAL TESTS: Independent sample's t-test, Fisher's exact test, or 
      chi-square test, Pearson's correlation (r) were applied. P </= 0.05 was considered 
      significant. RESULTS: Left ventricular end-diastolic/end-systolic volume index (P 
      = 0.643, P = 0.325, respectively), mass index (P = 0.719), and ejection fraction 
      (P = 0.144) were not significantly different between PM/DM patients and controls. 
      LGE was found in 19% of PM/DM patients and none of the control subjects. PM/DM 
      patients showed significantly higher native T(1) values (1263.7 +/- 84.0 msec vs. 
      1200.6 +/- 43.0 msec, P = 0.002) and expanded extracellular volume (ECV) (32.6 +/- 
      3.7% vs. 26.7 +/- 2.3%, P < 0.001) compared with control subjects. ECV values in 
      PM/DM patients had a high proportion (60%) over the 95% percentile of normal 
      controls. Meanwhile, there was a significant correlation between native T(1) (r = 
      0.710, P = 0.0001) or ECV (r = 0.508, P = 0.01) and N-terminal prohormone of 
      brain natriuretic peptide (NT-proBNP). DATA CONCLUSION: T(1) mapping of cardiac 
      MRI is valuable to detect subclinical myocardial involvement in PM/DM patients, 
      and both myocardial native T(1) and ECV could serve as early imaging markers for 
      myocardial impairment in PM/DM. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 3 
      J. MAGN. RESON. IMAGING 2018;48:415-422.
CI  - (c) 2018 International Society for Magnetic Resonance in Medicine.
FAU - Yu, Liuyu
AU  - Yu L
AD  - Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan 
      Province, China.
FAU - Sun, Jianhong
AU  - Sun J
AD  - Department of Rheumatology and Immunology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan Province, China.
FAU - Sun, Jiayu
AU  - Sun J
AD  - Radiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan 
      Province, China.
FAU - Li, Jiangbo
AU  - Li J
AD  - Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan 
      Province, China.
FAU - Dong, Yang
AU  - Dong Y
AD  - Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan 
      Province, China.
FAU - Zhou, Xiaoyue
AU  - Zhou X
AD  - Northeast Asia MR Collaboration, Siemens Healthcare, Shanghai, China.
FAU - Greiser, Andreas
AU  - Greiser A
AD  - Siemens Healthcare, Erlangen, Germany.
FAU - Han, Yuchi
AU  - Han Y
AD  - Department of Medicine (Cardiovascular Division), University of Pennsylvania, 
      Philadelphia, Pennsylvania, Pennsylvania, USA.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan 
      Province, China.
FAU - Xie, Qibing
AU  - Xie Q
AD  - Department of Rheumatology and Immunology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan Province, China.
FAU - Chen, Yucheng
AU  - Chen Y
AD  - Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan 
      Province, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180112
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Dermatomyositis/*diagnostic imaging
MH  - Disease Progression
MH  - Female
MH  - Heart/*diagnostic imaging
MH  - Heart Ventricles
MH  - Humans
MH  - Inflammation
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myositis/*diagnostic imaging
MH  - Polymyositis/*diagnostic imaging
MH  - Prospective Studies
MH  - Stroke Volume
MH  - Systole
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - T1 mapping
OT  - extracellular volume
OT  - idiopathic inflammatory myopathy
OT  - native T1
EDAT- 2018/01/13 06:00
MHDA- 2019/09/17 06:00
CRDT- 2018/01/13 06:00
PHST- 2017/10/17 00:00 [received]
PHST- 2017/12/21 00:00 [accepted]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
PHST- 2018/01/13 06:00 [entrez]
AID - 10.1002/jmri.25945 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2018 Aug;48(2):415-422. doi: 10.1002/jmri.25945. Epub 2018 
      Jan 12.