PMID- 29329033
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20180821
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 99
DP  - 2018 Mar
TI  - Onjisaponin B prevents cognitive impairment in a rat model of D-galactose-induced 
      aging.
PG  - 113-120
LID - S0753-3322(17)30286-X [pii]
LID - 10.1016/j.biopha.2018.01.006 [doi]
AB  - In this study, we investigated the potential effect of onjisaponin B (OB) on 
      aging rats induced by D-gal (D-galactose). Sub-acute aging model was established 
      in rats by the subcutaneous injection of D-gal (120 mg/kg) for 42 days, 
      accompanied with OB (10, 20 mg/kg, p.o.) or normal saline intervention for 28 
      days since the 14th day after the beginning of D-gal stimulation. Morris water 
      maze test and step-down passive avoidance test were conducted to evaluate the 
      cognitive function of the rats. The superoxidase dismutase (SOD), malondialdehyde 
      (MDA), glutathione (GSH) and glutathione peroxidase (GSH-px) contents in 
      hippocampus were measured by according kits, respectively. And the hippocampus 
      levels of inflammatory mediators including tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) were assayed by enzyme-linked 
      immunosorbent assay (ELISA). Furthermore, the expressions of SOD1, MDA5, GSH, 
      GSH-px, NF-small ka, CyrillicB pathway were present by western blot. It revealed that 
      administration of OB was able to significantly attenuate the D-gal-induced 
      changes in the hippocampus, ranging from cognitive capacity, oxidative stress to 
      inflammation response. In a nutshell, our data provided evidence that OB could 
      contribute to the restoration of cognitive ability by improving the antioxidant 
      and anti-inflammatory capacity in D-gal induced aging rats.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Li, Gaowen
AU  - Li G
AD  - Ningbo College of Health Sciences, Ningbo, Zhejiang Province 315100, China.
FAU - Yu, Jimian
AU  - Yu J
AD  - Ningbo College of Health Sciences, Ningbo, Zhejiang Province 315100, China.
FAU - Zhang, Ling
AU  - Zhang L
AD  - Ningbo College of Health Sciences, Ningbo, Zhejiang Province 315100, China.
FAU - Wang, Yong
AU  - Wang Y
AD  - Ningbo College of Health Sciences, Ningbo, Zhejiang Province 315100, China.
FAU - Wang, Chuang
AU  - Wang C
AD  - Medical School of Ningbo University, Ningbo, Zhejiang Province 315100, China.
FAU - Chen, Qun
AU  - Chen Q
AD  - Ningbo College of Health Sciences, Ningbo, Zhejiang Province 315100, China. 
      Electronic address: Small_swallows@163.com.
LA  - eng
PT  - Journal Article
DEP - 20180109
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Saponins)
RN  - 0 (Triterpenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (onjisaponin B)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Aging/*pathology
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Cognition Disorders/*drug therapy/*prevention & control
MH  - Disease Models, Animal
MH  - Galactose
MH  - Glutathione Peroxidase/metabolism
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Maze Learning/drug effects
MH  - NF-kappa B/metabolism
MH  - Rats, Sprague-Dawley
MH  - Saponins/pharmacology/*therapeutic use
MH  - Superoxide Dismutase/metabolism
MH  - Triterpenes/pharmacology/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Anti-inflammatory
OT  - Antioxidant
OT  - Cognitive impairment
OT  - Onjisaponin B
EDAT- 2018/01/13 06:00
MHDA- 2018/08/22 06:00
CRDT- 2018/01/13 06:00
PHST- 2017/01/18 00:00 [received]
PHST- 2017/12/27 00:00 [revised]
PHST- 2018/01/03 00:00 [accepted]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
PHST- 2018/01/13 06:00 [entrez]
AID - S0753-3322(17)30286-X [pii]
AID - 10.1016/j.biopha.2018.01.006 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Mar;99:113-120. doi: 10.1016/j.biopha.2018.01.006. Epub 
      2018 Jan 9.