PMID- 29329058
OWN - NLM
STAT- MEDLINE
DCOM- 20180907
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 229
DP  - 2018 Mar 15
TI  - Association of comorbid personality disorders with clinical characteristics and 
      outcome in a randomized controlled trial comparing two psychotherapies for 
      early-onset persistent depressive disorder.
PG  - 262-268
LID - S0165-0327(17)31053-4 [pii]
LID - 10.1016/j.jad.2017.12.091 [doi]
AB  - BACKGROUND: Persistent depressive disorder (PDD) is associated with high rates of 
      comorbid personality disorders (PD). The association of comorbid PD and clinical 
      characteristics has not been systematically studied in PDD. Results regarding 
      effects on treatment outcome are heterogeneous. METHODS: We analyzed the 
      association of comorbid personality disorders with clinical characteristics and 
      outcome in a randomized controlled trial comparing the disorder-specific 
      Cognitive Behavioral Analysis System of Psychotherapy (CBASP) with nonspecific 
      supportive psychotherapy (SP) in patients with early-onset PDD. The main outcome 
      measure was the Hamilton Rating Scale for Depression (HRSD-24). Further baseline 
      measures were comorbid axis-I diagnoses (SCID-I), quality of life (QLDS), global 
      functioning (GAF), interpersonal problems (IIP-64) and childhood maltreatment 
      (CTQ). RESULTS: Out of the 268 patients, 103 (38.4%) met criteria for at least 
      one PD. PD was associated with higher rates of axis I comorbidities (mainly 
      anxiety disorders) and interpersonal problems (patients with PD were more 
      vindictive, more self-sacrificing, less assertive and more inhibited socially 
      than patients without PD). There was no significant main effect of PD on 
      treatment outcome and no significant interaction between PD and treatment group. 
      LIMITATIONS: The main limitation was the exclusion of patients with certain 
      personality disorders (antisocial, schizotypal, and borderline personality 
      disorders). Furthermore, the study was underpowered to find interaction effects 
      of small size. CONCLUSION: Persistently depressed patients with and without 
      comorbid PD primarily seemed to differ in the rate of axis I comorbidity and the 
      severity of interpersonal problems. Treatment outcomes appear to be not 
      significantly affected by the presence of PD.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Erkens, Nele
AU  - Erkens N
AD  - Department of Psychiatry and Psychotherapy, Lubeck University, Lubeck, Germany. 
      Electronic address: nele.erkens@uksh.de.
FAU - Schramm, Elisabeth
AU  - Schramm E
AD  - Department of Psychiatry, Faculty of Medicine, University of Freiburg, Freiburg, 
      Germany.
FAU - Kriston, Levente
AU  - Kriston L
AD  - Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, 
      Hamburg, Germany.
FAU - Hautzinger, Martin
AU  - Hautzinger M
AD  - Department of Clinical Psychology and Psychotherapy, University of Tubingen, 
      Tubingen, Germany.
FAU - Harter, Martin
AU  - Harter M
AD  - Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, 
      Hamburg, Germany.
FAU - Schweiger, Ulrich
AU  - Schweiger U
AD  - Department of Psychiatry and Psychotherapy, Lubeck University, Lubeck, Germany.
FAU - Klein, Jan Philipp
AU  - Klein JP
AD  - Department of Psychiatry and Psychotherapy, Lubeck University, Lubeck, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT00970437
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180104
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Anxiety Disorders/psychology
MH  - Borderline Personality Disorder
MH  - Comorbidity
MH  - Depressive Disorder/psychology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Personality
MH  - Personality Disorders/epidemiology/*psychology
MH  - Psychiatric Status Rating Scales
MH  - Psychotherapy/*methods
MH  - Quality of Life
EDAT- 2018/01/13 06:00
MHDA- 2018/09/08 06:00
CRDT- 2018/01/13 06:00
PHST- 2017/05/30 00:00 [received]
PHST- 2017/11/24 00:00 [revised]
PHST- 2017/12/31 00:00 [accepted]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/09/08 06:00 [medline]
PHST- 2018/01/13 06:00 [entrez]
AID - S0165-0327(17)31053-4 [pii]
AID - 10.1016/j.jad.2017.12.091 [doi]
PST - ppublish
SO  - J Affect Disord. 2018 Mar 15;229:262-268. doi: 10.1016/j.jad.2017.12.091. Epub 
      2018 Jan 4.