PMID- 29330052
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20220330
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 496
IP  - 2
DP  - 2018 Feb 5
TI  - ESCO2 knockdown inhibits cell proliferation and induces apoptosis in human 
      gastric cancer cells.
PG  - 475-481
LID - S0006-291X(18)30054-8 [pii]
LID - 10.1016/j.bbrc.2018.01.048 [doi]
AB  - Establishment of cohesion 1 homolog 2 (ESCO2), an essential gene for cohesion 
      regulation and genomic stability, has not been studied in human gastric cancer 
      (GC). We found that ESCO2 knockdown in human GC cell lines dramatically inhibited 
      cell proliferation and induced cell apoptosis in vitro and suppressed tumor 
      xenograft development in vivo. Furthermore, adenosine monophosphate-activated 
      protein kinase (AMPK) was activated following the suppression of its downstream 
      targets, including mammalian target of rapamycin (mTOR) and p70 ribosomal S6 
      kinase 1 (p70S6K1), and this result was consistent with p53 activation. 
      Significantly, co-immunoprecipitation (Co-IP) analyses indicated that ESCO2 can 
      interact with p53 in GC cells. Taken together, our data demonstrate that ESCO2 is 
      essential for the development of GC and might be a potential therapeutic target 
      for treating GC.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Chen, Hongmei
AU  - Chen H
AD  - Institute of Cell Biology, School of Life Sciences, Lanzhou University, 222 
      Tian-Shui South Road, Lanzhou 730000, Gansu, China; Institute of Medical 
      Physiology and Psychology, School of Basic Medical Sciences, Lanzhou University, 
      199 Dong-Gang West Road, Lanzhou 730000, Gansu, China. Electronic address: 
      hmchen@lzu.edu.cn.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of General Surgery, The First Hospital of Lanzhou University, 1 
      Dong-Gang West Road, Lanzhou 730000, Gansu, China. Electronic address: 
      13993181644@139.com.
FAU - He, Wenting
AU  - He W
AD  - Second Hospital of Lanzhou University, 82 Cui-Yin Door, Lanzhou 730030, Gansu, 
      China; Key Laboratory of Digestive Tumor of Gansu Province, 82 Cui-Yin Door, 
      Lanzhou 730030, Gansu, China. Electronic address: hewt03@163.com.
FAU - Liu, Tao
AU  - Liu T
AD  - Second Hospital of Lanzhou University, 82 Cui-Yin Door, Lanzhou 730030, Gansu, 
      China; Key Laboratory of Digestive Tumor of Gansu Province, 82 Cui-Yin Door, 
      Lanzhou 730030, Gansu, China. Electronic address: ldyyliutao@163.com.
FAU - Zhao, Yang
AU  - Zhao Y
AD  - Second Hospital of Lanzhou University, 82 Cui-Yin Door, Lanzhou 730030, Gansu, 
      China; Key Laboratory of Digestive Tumor of Gansu Province, 82 Cui-Yin Door, 
      Lanzhou 730030, Gansu, China. Electronic address: zhaoyang0931@126.com.
FAU - Chen, Hao
AU  - Chen H
AD  - Second Hospital of Lanzhou University, 82 Cui-Yin Door, Lanzhou 730030, Gansu, 
      China; Key Laboratory of Digestive Tumor of Gansu Province, 82 Cui-Yin Door, 
      Lanzhou 730030, Gansu, China. Electronic address: chenhao3996913@163.com.
FAU - Li, Yumin
AU  - Li Y
AD  - Institute of Cell Biology, School of Life Sciences, Lanzhou University, 222 
      Tian-Shui South Road, Lanzhou 730000, Gansu, China; Second Hospital of Lanzhou 
      University, 82 Cui-Yin Door, Lanzhou 730030, Gansu, China; Key Laboratory of 
      Digestive Tumor of Gansu Province, 82 Cui-Yin Door, Lanzhou 730030, Gansu, China. 
      Electronic address: liym@lzu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180109
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.- (ESCO2 protein, human)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (ribosomal protein S6 kinase, 70kD, polypeptide 2)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - EC 2.7.11.31 (PRKAA1 protein, human)
SB  - IM
MH  - AMP-Activated Protein Kinases/genetics/metabolism
MH  - Acetyltransferases/antagonists & inhibitors/*genetics/metabolism
MH  - Animals
MH  - Apoptosis/genetics
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Chromosomal Proteins, Non-Histone/antagonists & inhibitors/*genetics/metabolism
MH  - Epithelial Cells/*metabolism/pathology
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Protein Binding
MH  - RNA, Small Interfering/genetics/metabolism
MH  - Ribosomal Protein S6 Kinases, 70-kDa/genetics/metabolism
MH  - Signal Transduction
MH  - Stomach Neoplasms/*genetics/metabolism/pathology
MH  - TOR Serine-Threonine Kinases/genetics/metabolism
MH  - Tumor Suppressor Protein p53/*genetics/metabolism
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - Apoptosis
OT  - ESCO2
OT  - Gastric cancer
OT  - Proliferation
EDAT- 2018/01/14 06:00
MHDA- 2018/02/14 06:00
CRDT- 2018/01/14 06:00
PHST- 2017/11/15 00:00 [received]
PHST- 2018/01/08 00:00 [accepted]
PHST- 2018/01/14 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
PHST- 2018/01/14 06:00 [entrez]
AID - S0006-291X(18)30054-8 [pii]
AID - 10.1016/j.bbrc.2018.01.048 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2018 Feb 5;496(2):475-481. doi: 
      10.1016/j.bbrc.2018.01.048. Epub 2018 Jan 9.