PMID- 29330390
OWN - NLM
STAT- MEDLINE
DCOM- 20190515
LR  - 20190719
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 53
IP  - 4
DP  - 2018 Apr
TI  - Freezing the graft is not necessary for autotransplants for plasma cell myeloma 
      and lymphomas.
PG  - 457-460
LID - 10.1038/s41409-017-0047-7 [doi]
AB  - We studied rates of granulocyte and platelets recovery in 359 consecutive 
      subjects receiving blood cell infusions in the context of autotransplants for 
      plasma cell myeloma (N = 216) and lymphomas (N = 143). Blood cells were mobilised 
      with filgrastim given for 4-5 days and collected after a median of 2 (range, 1-2) 
      apheresis. Apheresis products were stored at 4 degrees  C for a median of 3 days (range, 
      2-6 days). Most subjects received carmustine, etoposide, cytarabine and melphalan 
      (BEAM), cyclophosphamide, carmustine and etoposide (CBV) or high-dose melphalan. 
      Filgrastim was given post transplant to 319 subjects. Median numbers of 
      mononuclear cells collected was 31 x 10E + 6/kg (interquartile range (IQR) 
      37 x 10E + 6 cells/kg). Median numbers of CD34-positive cells collected was 
      3.6 x 10E + 6/kg (IQR 3.8 x 10E + 6/Kg). Median viability after collection was 
      90% (IQR 7%) after storage, 88% (IQR 12%). A total of 255 of 256 evaluable 
      subjects recovered bone marrow function and there was no late bone marrow 
      failure. Median interval to neutrophils >0.5 x E + 9/L was 13 days (range, 9-39 
      days) and to platelets >20 x 10E + 9/L, 16 days (range, 7-83 days). These rates 
      and ranges seem comparable to those reported after autotransplants of frozen 
      blood cells. There was no correlation between numbers of storage days at 4  degrees C and 
      viability afte storage (r = -0.018, p = 0.14)) nor rates of recovery of 
      neutrophils (r = -0.054, p = 0.52) or platelets (r = 0.116, p = 0.14). Blood 
      cells collected for autotransplant can be stored at 4  degrees C for 6 d. This method is 
      simple, inexpensive and widely applicable.
FAU - Kardduss-Urueta, Amado
AU  - Kardduss-Urueta A
AUID- ORCID: 0000-0001-8372-102X
AD  - Instituto de Cancerologia. Clinica las Americas, Medellin, Colombia.
FAU - Gale, Robert Peter
AU  - Gale RP
AUID- ORCID: 0000-0002-9156-1676
AD  - Imperial College London, London, UK.
FAU - Gutierrez-Aguirre, Cesar H
AU  - Gutierrez-Aguirre CH
AD  - Hospital Universitario de Nuevo Leon, Monterrey, Mexico.
FAU - Herrera-Rojas, Miguel Angel
AU  - Herrera-Rojas MA
AD  - Hospital Universitario de Nuevo Leon, Monterrey, Mexico.
FAU - Murrieta-Alvarez, Ivan
AU  - Murrieta-Alvarez I
AD  - Centro de Hematologia y Medicina Interna de Puebla, Puebla, Puebla, Mexico.
AD  - Laboratorios Clinicos de Puebla, Puebla, Puebla, Mexico.
FAU - Perez-Fontalvo, Rosendo
AU  - Perez-Fontalvo R
AD  - Instituto de Cancerologia. Clinica las Americas, Medellin, Colombia.
FAU - Ruiz-Delgado, Guillermo J
AU  - Ruiz-Delgado GJ
AD  - Centro de Hematologia y Medicina Interna de Puebla, Puebla, Puebla, Mexico.
AD  - Laboratorios Clinicos de Puebla, Puebla, Puebla, Mexico.
FAU - Ruiz-Rojas, Giovanni
AU  - Ruiz-Rojas G
AD  - Instituto de Cancerologia. Clinica las Americas, Medellin, Colombia.
FAU - Jaimovich, Gregorio
AU  - Jaimovich G
AD  - Sanatorio Anchorena, Buenos Aires, Argentina.
FAU - Feldman, Leonardo
AU  - Feldman L
AD  - Hospital Universitario Favaloro, Buenos Aires, Argentina.
FAU - Labastida-Mercado, Nancy
AU  - Labastida-Mercado N
AD  - Centro de Hematologia y Medicina Interna de Puebla, Puebla, Puebla, Mexico.
FAU - Endara, Alicia
AU  - Endara A
AD  - Hospital Universitario Favaloro, Buenos Aires, Argentina.
FAU - Castro, Martin
AU  - Castro M
AD  - Sanatorio Anchorena, Buenos Aires, Argentina.
FAU - Galindo-Becerra, Samantha
AU  - Galindo-Becerra S
AD  - Centro de Hematologia y Medicina Interna de Puebla, Puebla, Puebla, Mexico.
FAU - Cardona-Molina, Maria Angelica
AU  - Cardona-Molina MA
AD  - Instituto de Cancerologia. Clinica las Americas, Medellin, Colombia.
FAU - Gomez-Almaguer, David
AU  - Gomez-Almaguer D
AD  - Hospital Universitario de Nuevo Leon, Monterrey, Mexico.
FAU - Ruiz-Arguelles, Guillermo J
AU  - Ruiz-Arguelles GJ
AUID- ORCID: 0000-0002-9335-0653
AD  - Centro de Hematologia y Medicina Interna de Puebla, Puebla, Puebla, Mexico. 
      gruiz1@hsctmexico.com.
AD  - Laboratorios Clinicos de Puebla, Puebla, Puebla, Mexico. gruiz1@hsctmexico.com.
LA  - eng
PT  - Journal Article
DEP - 20180112
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Autografts
MH  - Blood Component Removal/methods
MH  - Blood Preservation/methods
MH  - Cell Survival
MH  - Child
MH  - Child, Preschool
MH  - *Freezing
MH  - Graft Survival
MH  - Hematopoietic Stem Cell Mobilization/methods
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Lymphoma/*therapy
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*therapy
MH  - Young Adult
EDAT- 2018/01/14 06:00
MHDA- 2019/05/16 06:00
CRDT- 2018/01/14 06:00
PHST- 2017/09/08 00:00 [received]
PHST- 2017/10/30 00:00 [accepted]
PHST- 2018/01/14 06:00 [pubmed]
PHST- 2019/05/16 06:00 [medline]
PHST- 2018/01/14 06:00 [entrez]
AID - 10.1038/s41409-017-0047-7 [pii]
AID - 10.1038/s41409-017-0047-7 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2018 Apr;53(4):457-460. doi: 10.1038/s41409-017-0047-7. 
      Epub 2018 Jan 12.