PMID- 29330559
OWN - NLM
STAT- MEDLINE
DCOM- 20180809
LR  - 20181202
IS  - 1432-0428 (Electronic)
IS  - 0012-186X (Linking)
VI  - 61
IP  - 4
DP  - 2018 Apr
TI  - A post-translational balancing act: the good and the bad of SUMOylation in 
      pancreatic islets.
PG  - 775-779
LID - 10.1007/s00125-017-4543-5 [doi]
AB  - Post-translational modification of proteins contributes to the control of cell 
      function and survival. The balance of these in insulin-producing pancreatic beta 
      cells is important for the maintenance of glucose homeostasis. Protection from 
      the damaging effects of reactive oxygen species is required for beta cell 
      survival, but if this happens at the expense of insulin secretory function then 
      the ability of islets to respond to changing metabolic conditions may be 
      compromised. In this issue of Diabetologia, He et al ( 
      https://doi.org/10.1007/s00125-017-4523-9 ) show that post-translational 
      attachment of small ubiquitin-like modifier (SUMO) to target lysine residues 
      (SUMOylation) strikes an important balance between the protection of beta cells 
      from oxidative stress and the maintenance of insulin secretory function. They 
      show that SUMOylation is required to stabilise nuclear factor erythroid 2-related 
      factor 2 (NRF2) and increase antioxidant gene expression. Decreasing SUMOylation 
      in beta cells impairs their antioxidant capacity, causes cell death, 
      hyperglycaemia, and increased sensitivity to streptozotocin-induced diabetes, 
      while increasing SUMOylation is protective. However, this protection from overt 
      diabetes occurs in concert with glucose intolerance due to impaired beta cell 
      function. A possible role for SUMOylation as a key factor balancing beta cell 
      protection vs beta cell responsiveness to metabolic cues is discussed in this 
      Commentary.
FAU - MacDonald, Patrick E
AU  - MacDonald PE
AD  - Department of Pharmacology, University of Alberta, Edmonton, AB, Canada. 
      pmacdonald@ualberta.ca.
AD  - Alberta Diabetes Institute, LKS Centre, Rm. 6-126, University of Alberta, 
      Edmonton, AB, T6G 2E1, Canada. pmacdonald@ualberta.ca.
LA  - eng
GR  - 148451/CIHR/Canada
PT  - Comment
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180112
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Insulin)
SB  - IM
CON - Diabetologia. 2018 Apr;61(4):881-895. PMID: 29299635
MH  - Humans
MH  - Insulin
MH  - Insulin-Secreting Cells
MH  - *Islets of Langerhans
MH  - Male
MH  - Protein Processing, Post-Translational
MH  - *Sumoylation
OTO - NOTNLM
OT  - Apoptosis
OT  - Diabetes
OT  - Insulin
OT  - Islets
OT  - Oxidative stress
OT  - Redox
OT  - SENP1
OT  - SUMOylation
OT  - Secretion
OT  - UBC9
EDAT- 2018/01/14 06:00
MHDA- 2018/08/10 06:00
CRDT- 2018/01/14 06:00
PHST- 2017/12/14 00:00 [received]
PHST- 2017/12/20 00:00 [accepted]
PHST- 2018/01/14 06:00 [pubmed]
PHST- 2018/08/10 06:00 [medline]
PHST- 2018/01/14 06:00 [entrez]
AID - 10.1007/s00125-017-4543-5 [pii]
AID - 10.1007/s00125-017-4543-5 [doi]
PST - ppublish
SO  - Diabetologia. 2018 Apr;61(4):775-779. doi: 10.1007/s00125-017-4543-5. Epub 2018 
      Jan 12.