PMID- 29330839
OWN - NLM
STAT- MEDLINE
DCOM- 20190226
LR  - 20240329
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 55
IP  - 8
DP  - 2018 Aug
TI  - Peripheral Blood Brain-Derived Neurotrophic Factor as a Biomarker of Alzheimer's 
      Disease: Are There Methodological Biases?
PG  - 6661-6672
LID - 10.1007/s12035-017-0866-y [doi]
AB  - Mounting evidence that alterations in brain-derived neurotrophic factor (BDNF) 
      levels and signaling may be involved in the etiopathogenesis of Alzheimer's 
      disease (AD) has suggested that its blood levels could be used as a biomarker of 
      the disease. However, higher, lower, or unchanged circulating BDNF levels have 
      all been described in AD patients compared to healthy controls. Although the 
      reasons for such different findings are unclear, methodological issues are likely 
      to be involved. The heterogeneity of participant recruitment criteria and the 
      lack of control of variables that influence circulating BDNF levels regardless of 
      dementia (depressive symptoms, medications, lifestyle, lack of overlap between 
      serum and plasma, and experimental aspects) are likely to bias result and prevent 
      study comparability. The present work reviews a broad panel of factors, whose 
      close control could help reduce the inconsistency of study findings, and offers 
      practical advice on their management. Research directed at elucidating the weight 
      of each of these variables and at standardizing analytical methodologies is 
      urgently needed.
FAU - Balietti, Marta
AU  - Balietti M
AUID- ORCID: 0000-0002-3123-7903
AD  - Center for Neurobiology of Aging, INRCA, Via Birarelli 8, 60121, Ancona, Italy. 
      m.balietti@inrca.it.
FAU - Giuli, Cinzia
AU  - Giuli C
AD  - Geriatrics Operative Unit, INRCA, Fermo, 63023, Italy.
FAU - Conti, Fiorenzo
AU  - Conti F
AD  - Center for Neurobiology of Aging, INRCA, Via Birarelli 8, 60121, Ancona, Italy.
AD  - Department of Experimental and Clinical Medicine, Section of Neuroscience and 
      Cell Biology, Universita Politecnica delle Marche, Ancona, 60126, Italy.
LA  - eng
GR  - 154/GR-2009-1584108/Italian Ministry of Health and Regione Marche/
PT  - Journal Article
PT  - Review
DEP - 20180113
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Alzheimer Disease/*blood/complications/drug therapy
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depression/etiology
MH  - Humans
MH  - Life Style
MH  - Models, Biological
PMC - PMC6061178
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Biomarker
OT  - Blood
OT  - Brain-derived neurotrophic factor
OT  - Confounding variables
COIS- The authors declare that they have no conflict of interest.
EDAT- 2018/01/14 06:00
MHDA- 2019/02/27 06:00
PMCR- 2018/01/13
CRDT- 2018/01/14 06:00
PHST- 2017/10/03 00:00 [received]
PHST- 2017/12/26 00:00 [accepted]
PHST- 2018/01/14 06:00 [pubmed]
PHST- 2019/02/27 06:00 [medline]
PHST- 2018/01/14 06:00 [entrez]
PHST- 2018/01/13 00:00 [pmc-release]
AID - 10.1007/s12035-017-0866-y [pii]
AID - 866 [pii]
AID - 10.1007/s12035-017-0866-y [doi]
PST - ppublish
SO  - Mol Neurobiol. 2018 Aug;55(8):6661-6672. doi: 10.1007/s12035-017-0866-y. Epub 
      2018 Jan 13.