PMID- 2933125
OWN - NLM
STAT- MEDLINE
DCOM- 19860122
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 348
IP  - 1
DP  - 1985 Nov 25
TI  - The action of centrally administered arginine vasopressin on blood pressure in 
      the conscious rabbit.
PG  - 137-45
AB  - In addition to its peripheral endocrine actions, arginine vasopressin (AVP) has 
      been implicated in the central control of blood pressure. Intracerebroventricular 
      (i.c.v.) injections (0.01-1.0 nmol) of AVP or arginine vasotocin (AVT), but not 
      oxytocin (OXY), into unanesthetized rabbits caused a rapid, dose related rise in 
      blood pressure as well as increases in heart rate. The lowest centrally 
      administered dose of AVP and AVT (0.01 nmol) had no effect on blood pressure when 
      given intravenously. In search of tissue locus for the pressor effect of AVP 
      microinjection of AVP and OXY into the posterior hypothalamus and septum of 
      conscious rabbits was without effect. However, microinjection (0.01-0.04 nmol) of 
      AVP into the nucleus tractus solitarius of anesthetized rabbits caused a rise in 
      blood pressure similar to the response seen after i.c.v. injection. Comparable 
      volumes of the vehicle into the ventricle or the tissue sites had no effect on 
      resting blood pressure. The pressor response after AVP given i.c.v. was 
      significantly reduced up to 3 h after administration of the ganglionic blocker, 
      chlorisondamine HCl. The central antagonist, d(CH2)5Tyr (Me) vasopressin, 
      eliminated the usual increase in blood pressure after administration of AVP in 
      half the animals tested. The results indicate that AVP acts centrally to mediate 
      cardiovascular responses in unanesthetized as well as anesthetized rabbits.
FAU - Martin, S M
AU  - Martin SM
FAU - Malkinson, T J
AU  - Malkinson TJ
FAU - Veale, W L
AU  - Veale WL
FAU - Pittman, Q J
AU  - Pittman QJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Angiotensin)
RN  - 0 (Receptors, Vasopressin)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 50-56-6 (Oxytocin)
RN  - W6S6URY8OF (Vasotocin)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Brain/*drug effects
MH  - Brain Mapping
MH  - Hypothalamus, Posterior/drug effects
MH  - Male
MH  - Medulla Oblongata/drug effects
MH  - Oxytocin/*pharmacology
MH  - Rabbits
MH  - Receptors, Angiotensin/drug effects
MH  - Receptors, Vasopressin
MH  - Septum Pellucidum/drug effects
MH  - Vasotocin/*pharmacology
EDAT- 1985/11/25 00:00
MHDA- 1985/11/25 00:01
CRDT- 1985/11/25 00:00
PHST- 1985/11/25 00:00 [pubmed]
PHST- 1985/11/25 00:01 [medline]
PHST- 1985/11/25 00:00 [entrez]
AID - 0006-8993(85)90369-5 [pii]
AID - 10.1016/0006-8993(85)90369-5 [doi]
PST - ppublish
SO  - Brain Res. 1985 Nov 25;348(1):137-45. doi: 10.1016/0006-8993(85)90369-5.