PMID- 29331618
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20191210
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 46
IP  - 2
DP  - 2018 Mar-Apr
TI  - Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae 
      drops in pre-school and school-age children with allergic rhinitis.
PG  - 107-111
LID - S0301-0546(17)30182-9 [pii]
LID - 10.1016/j.aller.2017.09.022 [doi]
AB  - BACKGROUND: The safety and efficacy of sublingual immunotherapy (SLIT) have been 
      confirmed by many studies. However, in China, the research on efficacy and safety 
      in young and older children with allergic rhinitis (AR) is still rare. OBJECTIVE: 
      The aim of this retrospective study is to evaluate the efficacy and safety of 
      SLIT with Dermatophagoides farinae drops in pre-school and school-age children 
      with AR. METHODS: A total of 282 subjects aged 2-13 years with AR received a 
      two-year course of sublingual immunotherapy along with pharmacotherapy. According 
      to the age, patients were defined as the pre-school group (2-6 years old, n=116) 
      and school-age group (7-13 years old, n=166). Total nasal rhinitis symptom scores 
      (TNSS), visual analogue score (VAS) and total medication scores (TMS) were 
      evaluated at four time points: baseline, after SLIT for half a year, one year and 
      two years. The adverse events (AEs) were evaluated at each visit. RESULTS: After 
      two-year SLIT, the four rhinitis symptom scores, TNSS, VAS and TMS scores were 
      significantly lower than baseline (all P<0.05). The comparison of efficacy 
      between one and two-year duration showed no significant difference in global 
      clinical outcomes (all P>0.05). In addition, there were no significant 
      differences between the pre-school and school-age group in TNSS (all P>0.05), VAS 
      (all P>0.05) and TMS scores (P>0.05) after SLIT for half a year, one year and two 
      years. No severe systemic AEs were reported. CONCLUSION: SLIT with D. farinae 
      drops is clinically effective and safe in pre-school and school-age patients with 
      house dust mites (HDMs)-induced AR.
CI  - Copyright (c) 2018 SEICAP. Published by Elsevier Espana, S.L.U. All rights 
      reserved.
FAU - Tang, L-X
AU  - Tang LX
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, 
      Capital Medical University, Beijing 100045, China.
FAU - Yang, X-J
AU  - Yang XJ
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, 
      Capital Medical University, Beijing 100045, China.
FAU - Wang, P-P
AU  - Wang PP
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, 
      Capital Medical University, Beijing 100045, China.
FAU - Ge, W-T
AU  - Ge WT
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, 
      Capital Medical University, Beijing 100045, China.
FAU - Zhang, J
AU  - Zhang J
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, 
      Capital Medical University, Beijing 100045, China.
FAU - Guo, Y-L
AU  - Guo YL
AD  - Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck 
      Surgery, Beijing Pediatric Research Institute, Capital Medical University, 
      Beijing 100020, China.
FAU - Lu, J
AU  - Lu J
AD  - Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck 
      Surgery, Beijing Pediatric Research Institute, Capital Medical University, 
      Beijing 100020, China.
FAU - Tai, J
AU  - Tai J
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, 
      Capital Medical University, Beijing 100045, China.
FAU - Zhang, Y-M
AU  - Zhang YM
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, 
      Capital Medical University, Beijing 100045, China.
FAU - Ni, X
AU  - Ni X
AD  - Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, 
      Capital Medical University, Beijing 100045, China; Beijing Key Laboratory for 
      Pediatric Diseases of Otolaryngology-Head and Neck Surgery, Beijing Pediatric 
      Research Institute, Capital Medical University, Beijing 100020, China. Electronic 
      address: nixin@bch.com.cn.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20180111
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Antigens, Dermatophagoides)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Dermatophagoides farinae/immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Population
MH  - Retrospective Studies
MH  - Rhinitis, Allergic/immunology/*therapy
MH  - Sublingual Immunotherapy/*methods
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - D. farinae
OT  - Efficacy
OT  - Sublingual immunotherapy
EDAT- 2018/01/15 06:00
MHDA- 2018/08/17 06:00
CRDT- 2018/01/15 06:00
PHST- 2017/05/19 00:00 [received]
PHST- 2017/07/31 00:00 [revised]
PHST- 2017/09/13 00:00 [accepted]
PHST- 2018/01/15 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2018/01/15 06:00 [entrez]
AID - S0301-0546(17)30182-9 [pii]
AID - 10.1016/j.aller.2017.09.022 [doi]
PST - ppublish
SO  - Allergol Immunopathol (Madr). 2018 Mar-Apr;46(2):107-111. doi: 
      10.1016/j.aller.2017.09.022. Epub 2018 Jan 11.