PMID- 29332633
OWN - NLM
STAT- MEDLINE
DCOM- 20190923
LR  - 20220330
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Linking)
VI  - 105
DP  - 2018 Feb
TI  - Impact of psychological factors on the health-related quality of life of patients 
      treated for pulmonary arterial hypertension.
PG  - 45-51
LID - S0022-3999(17)30472-5 [pii]
LID - 10.1016/j.jpsychores.2017.12.003 [doi]
AB  - OBJECTIVE: Pulmonary arterial hypertension (PAH) is a rare and life-threatening 
      disease well-marked by under diagnosis, delayed diagnosis and atypical 
      treatments. Few data are available on the quality of life (QoL) and psychosocial 
      characteristics of patients with PAH. Our aim is to describe the impact of 
      psychological factors on the health-related quality of life (HRQoL) of treated 
      PAH patients in a cross-sectional study. METHODS: Consecutive patients presenting 
      at our Competency Centre for PAH were recruited. The aetiology, New York Heart 
      Association (NYHA) stage, haemodynamics, 6-min walk distance (6MWD), delta SPO(2) 
      (Pulse oximeter oxygen saturation; baseline lowest value during 6-min walk test 
      (6MWT), current treatments and psychological history were recorded. HRQoL, 
      anxiety, depression and coping strategies were explored using self-administered 
      questionnaires (SF-36, HADS, STAI-Y, CHIP and WCC). RESULTS: A total of 55 
      patients were included. The HRQoL of PAH patients was poor with altered results 
      on several scales. Anxiety and depression were high and coping was focused on 
      medical information strategies. Multivariate analysis indicated a positive 
      relationship between 6MWD and the Physical Composite Score for QoL (p=0.004), as 
      well as a negative relationship between delta SPO(2) and the Mental Composite 
      Score (p=0.02), irrespective of other known prognostic factors (such as 
      haemodynamics at right heart catheterization). Depression and Trait-Anxiety were 
      associated with a lower physical (p=0.001) and mental (p<0.001) QoL, 
      respectively. CONCLUSIONS: Psychological factors impact the HRQoL of treated 
      patients. A longitudinal and qualitative study should refine these results. TRIAL 
      REGISTRATION: Clinical trial N degrees : NCT01380054.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Halimi, Laurence
AU  - Halimi L
AD  - Regional Competency Centre for PAH, CHU Arnaud de Villeneuve, Montpellier, 
      France; Department of Respiratory Diseases, CHU Arnaud de Villeneuve, 
      Montpellier, France. Electronic address: l-halimi@chu-montpellier.fr.
FAU - Marin, Gregory
AU  - Marin G
AD  - Department Medical Information, Montpellier University Hospitals, Montpellier, 
      France.
FAU - Molinari, Nicolas
AU  - Molinari N
AD  - Department Medical Information, Montpellier University Hospitals, Montpellier, 
      France; Institut Montpellierain Alexander Grothendieck, CNRS, University of 
      Montpellier, France.
FAU - Gamez, Anne-Sophie
AU  - Gamez AS
AD  - Department of Respiratory Diseases, CHU Arnaud de Villeneuve, Montpellier, 
      France.
FAU - Boissin, Clement
AU  - Boissin C
AD  - Regional Competency Centre for PAH, CHU Arnaud de Villeneuve, Montpellier, 
      France; Department of Respiratory Diseases, CHU Arnaud de Villeneuve, 
      Montpellier, France.
FAU - Suehs, Carey M
AU  - Suehs CM
AD  - Department of Respiratory Diseases, CHU Arnaud de Villeneuve, Montpellier, 
      France; Department Medical Information, Montpellier University Hospitals, 
      Montpellier, France.
FAU - Vachier, Isabelle
AU  - Vachier I
AD  - Department of Respiratory Diseases, CHU Arnaud de Villeneuve, Montpellier, 
      France.
FAU - Bourdin, Arnaud
AU  - Bourdin A
AD  - Regional Competency Centre for PAH, CHU Arnaud de Villeneuve, Montpellier, 
      France; Department of Respiratory Diseases, CHU Arnaud de Villeneuve, 
      Montpellier, France; PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 
      9214, Montpellier Hospital, Montpellier, France.
LA  - eng
SI  - ClinicalTrials.gov/NCT01380054
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171206
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Aged
MH  - Anxiety/etiology/*psychology
MH  - Cross-Sectional Studies
MH  - Depression/etiology/*psychology
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/*psychology/therapy
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Quality of Life/*psychology
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - 6-min walk distance
OT  - Anxiety-depression
OT  - Coping
OT  - Health-related quality of life
OT  - Oxygen desaturation
OT  - Pulmonary arterial hypertension
EDAT- 2018/01/16 06:00
MHDA- 2019/09/24 06:00
CRDT- 2018/01/16 06:00
PHST- 2017/05/05 00:00 [received]
PHST- 2017/11/30 00:00 [revised]
PHST- 2017/12/01 00:00 [accepted]
PHST- 2018/01/16 06:00 [entrez]
PHST- 2018/01/16 06:00 [pubmed]
PHST- 2019/09/24 06:00 [medline]
AID - S0022-3999(17)30472-5 [pii]
AID - 10.1016/j.jpsychores.2017.12.003 [doi]
PST - ppublish
SO  - J Psychosom Res. 2018 Feb;105:45-51. doi: 10.1016/j.jpsychores.2017.12.003. Epub 
      2017 Dec 6.