PMID- 29332878
OWN - NLM
STAT- MEDLINE
DCOM- 20180613
LR  - 20180613
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 58
IP  - 12
DP  - 2017
TI  - [Impact of HLA mismatch on transplant outcomes].
PG  - 2415-2424
LID - 10.11406/rinketsu.58.2415 [doi]
AB  - Human leukocyte antigen (HLA) mismatch increases the risk of severe 
      graft-versus-host disease (GVHD) and transplant-related mortality. However, the 
      variety of stem cell sources such as cord blood units or the improvements in GVHD 
      prophylaxis makes the interpretation of HLA mismatch more complex. In unrelated 
      transplantation, the locus of HLA mismatch has a great impact on the donor 
      candidate selection, whereas in related transplantation, it has an impact on the 
      intensity of GVHD prophylaxis because donor availability is limited. 
      Anti-thymocyte globulin and post-transplant cyclophosphamide are attractive GVHD 
      prophylactic agents to reduce the risk of immune-associated complications in 
      HLA-mismatched transplantations. HLA mismatch has a reduced impact in adult cord 
      blood transplantation. In this review article, the impact of HLA mismatch based 
      on graft sources is discussed.
FAU - Kanda, Junya
AU  - Kanda J
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Graft vs Host Disease/immunology
MH  - HLA Antigens/*immunology
MH  - Hematologic Neoplasms/*immunology/*therapy
MH  - Histocompatibility Testing
MH  - Humans
MH  - Stem Cell Transplantation/adverse effects
MH  - Transplantation, Homologous/adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cord blood transplantation
OT  - HLA mismatch
OT  - Related transplantation
OT  - Unrelated transplantation
EDAT- 2018/01/16 06:00
MHDA- 2018/06/14 06:00
CRDT- 2018/01/16 06:00
PHST- 2018/01/16 06:00 [entrez]
PHST- 2018/01/16 06:00 [pubmed]
PHST- 2018/06/14 06:00 [medline]
AID - 10.11406/rinketsu.58.2415 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2017;58(12):2415-2424. doi: 10.11406/rinketsu.58.2415.