PMID- 29332935
OWN - NLM
STAT- MEDLINE
DCOM- 20190815
LR  - 20190815
IS  - 1759-507X (Electronic)
IS  - 1759-5061 (Linking)
VI  - 14
IP  - 4
DP  - 2018 Apr
TI  - Novel treatment strategies for chronic kidney disease: insights from the animal 
      kingdom.
PG  - 265-284
LID - 10.1038/nrneph.2017.169 [doi]
AB  - Many of the >2 million animal species that inhabit Earth have developed survival 
      mechanisms that aid in the prevention of obesity, kidney disease, starvation, 
      dehydration and vascular ageing; however, some animals remain susceptible to 
      these complications. Domestic and captive wild felids, for example, show 
      susceptibility to chronic kidney disease (CKD), potentially linked to the high 
      protein intake of these animals. By contrast, naked mole rats are a model of 
      longevity and are protected from extreme environmental conditions through 
      mechanisms that provide resistance to oxidative stress. Biomimetic studies 
      suggest that the transcription factor nuclear factor erythroid 2-related factor 2 
      (NRF2) offers protection in extreme environmental conditions and promotes 
      longevity in the animal kingdom. Similarly, during months of fasting, 
      immobilization and anuria, hibernating bears are protected from muscle wasting, 
      azotaemia, thrombotic complications, organ damage and osteoporosis - features 
      that are often associated with CKD. Improved understanding of the susceptibility 
      and protective mechanisms of these animals and others could provide insights into 
      novel strategies to prevent and treat several human diseases, such as CKD and 
      ageing-associated complications. An integrated collaboration between 
      nephrologists and experts from other fields, such as veterinarians, zoologists, 
      biologists, anthropologists and ecologists, could introduce a novel approach for 
      improving human health and help nephrologists to find novel treatment strategies 
      for CKD.
FAU - Stenvinkel, Peter
AU  - Stenvinkel P
AD  - Divison of Renal Medicine M99, Karolinska University Hospital, Karolinska 
      Institutet, Halsovagen 13, 14157 Stockholm, Sweden.
FAU - Painer, Johanna
AU  - Painer J
AD  - Konrad Lorenz Institute of Ethology and Research Institute of Wildlife Ecology, 
      Department of Integrative Biology and Evolution at the University of Veterinary 
      Medicine, Savoyenstreet 1, 1160 Vienna, Austria.
FAU - Kuro-O, Makoto
AU  - Kuro-O M
AD  - Division of Anti-Aging Medicine, Center for Molecular Medicine, Jichi Medical 
      University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
FAU - Lanaspa, Miguel
AU  - Lanaspa M
AD  - Division of Renal Diseases and Hypertension, 12700 East 19th Avenue, Room 7015 
      Mail Stop C281, University of Colorado Anschutz Medical Campus, Aurora, Colorado 
      80045, USA.
FAU - Arnold, Walter
AU  - Arnold W
AD  - Konrad Lorenz Institute of Ethology and Research Institute of Wildlife Ecology, 
      Department of Integrative Biology and Evolution at the University of Veterinary 
      Medicine, Savoyenstreet 1, 1160 Vienna, Austria.
FAU - Ruf, Thomas
AU  - Ruf T
AD  - Konrad Lorenz Institute of Ethology and Research Institute of Wildlife Ecology, 
      Department of Integrative Biology and Evolution at the University of Veterinary 
      Medicine, Savoyenstreet 1, 1160 Vienna, Austria.
FAU - Shiels, Paul G
AU  - Shiels PG
AD  - Wolfson Wohl Translational Research Centre, University of Glasgow, Garscube 
      Estate, Switchback Road, Bearsden, Glasgow G61 1QH, UK.
FAU - Johnson, Richard J
AU  - Johnson RJ
AD  - Division of Renal Diseases and Hypertension, 12700 East 19th Avenue, Room 7015 
      Mail Stop C281, University of Colorado Anschutz Medical Campus, Aurora, Colorado 
      80045, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20180115
PL  - England
TA  - Nat Rev Nephrol
JT  - Nature reviews. Nephrology
JID - 101500081
RN  - 0 (Antioxidants)
RN  - 0 (NF-E2-Related Factor 2)
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Disease Susceptibility/*veterinary
MH  - Longevity/physiology
MH  - NF-E2-Related Factor 2/physiology
MH  - Oxidative Stress/physiology
MH  - Renal Insufficiency, Chronic/*therapy/*veterinary
EDAT- 2018/01/16 06:00
MHDA- 2019/08/16 06:00
CRDT- 2018/01/16 06:00
PHST- 2018/01/16 06:00 [pubmed]
PHST- 2019/08/16 06:00 [medline]
PHST- 2018/01/16 06:00 [entrez]
AID - nrneph.2017.169 [pii]
AID - 10.1038/nrneph.2017.169 [doi]
PST - ppublish
SO  - Nat Rev Nephrol. 2018 Apr;14(4):265-284. doi: 10.1038/nrneph.2017.169. Epub 2018 
      Jan 15.