PMID- 29333181
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2017
DP  - 2017
TI  - Study on the Inhibitory Effects of Ephedra Aconite Asarum Decoction on 
      LPS-Induced Dendritic Cells.
PG  - 3272649
LID - 10.1155/2017/3272649 [doi]
LID - 3272649
AB  - Dendritic cells (DCs) can secrete cytokines stimulated by lipopolysaccharide 
      (LPS), which leads to not just acute inflammatory responses but also Th1 
      polarization. Furtherly, chronic inflammation or autoimmune diseases could be 
      triggered. As a classic Traditional Chinese Medicine formula, Ephedra Aconite 
      Asarum Decoction with the main ingredients of ephedrine and hypaconitine can show 
      effect on anti-inflammation and immunoregulation. But it remains unclear whether 
      Ephedra Aconite Asarum Decoction controls DCs. In this study, we investigated the 
      effects of Ephedra Aconite Asarum Decoction on LPS-induced bone marrow-derived 
      DCs (BMDCs) in vitro. We found that Ephedra Aconite Asarum Decoction lowered 
      surface costimulators on DCs and reduced the expression of Th1 type cytokines. 
      Yet it is slightly beneficial for shifting to Th2. Our work reveals that the 
      Ephedra Aconite Asarum Decoction can regulate Th1 inflammation through 
      intervening DCs.
FAU - Ji, Wenting
AU  - Ji W
AUID- ORCID: 0000-0001-7052-4043
AD  - Beijing University of Chinese Medicine, Beijing 100029, China.
FAU - Hu, Jinghong
AU  - Hu J
AD  - Beijing University of Chinese Medicine, Beijing 100029, China.
FAU - Yu, Xue
AU  - Yu X
AD  - Beijing University of Chinese Medicine, Beijing 100029, China.
FAU - Zhang, Lanlan
AU  - Zhang L
AD  - Beijing University of Chinese Medicine, Beijing 100029, China.
FAU - Liu, Min
AU  - Liu M
AUID- ORCID: 0000-0002-2665-0584
AD  - Beijing University of Chinese Medicine, Beijing 100029, China.
FAU - Wang, Qingguo
AU  - Wang Q
AUID- ORCID: 0000-0002-2865-903X
AD  - Beijing University of Chinese Medicine, Beijing 100029, China.
LA  - eng
PT  - Journal Article
DEP - 20171126
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5733235
EDAT- 2018/01/16 06:00
MHDA- 2018/01/16 06:01
PMCR- 2017/11/26
CRDT- 2018/01/16 06:00
PHST- 2017/07/03 00:00 [received]
PHST- 2017/10/04 00:00 [revised]
PHST- 2017/10/09 00:00 [accepted]
PHST- 2018/01/16 06:00 [entrez]
PHST- 2018/01/16 06:00 [pubmed]
PHST- 2018/01/16 06:01 [medline]
PHST- 2017/11/26 00:00 [pmc-release]
AID - 10.1155/2017/3272649 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2017;2017:3272649. doi: 10.1155/2017/3272649. 
      Epub 2017 Nov 26.