PMID- 29333326
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2093-2278 (Print)
IS  - 2093-2286 (Electronic)
IS  - 2093-2278 (Linking)
VI  - 47
IP  - 6
DP  - 2017 Dec
TI  - Evaluation of the periodontal regenerative properties of patterned human 
      periodontal ligament stem cell sheets.
PG  - 402-415
LID - 10.5051/jpis.2017.47.6.402 [doi]
AB  - PURPOSE: The aim of this study was to determine the effects of patterned human 
      periodontal ligament stem cell (hPDLSC) sheets fabricated using a 
      thermoresponsive substratum. METHODS: In this study, we fabricated patterned 
      hPDLSC sheets using nanotopographical cues to modulate the alignment of the cell 
      sheet. RESULTS: The hPDLSCs showed rapid monolayer formation on various surface 
      pattern widths. Compared to cell sheets grown on flat surfaces, there were no 
      significant differences in cell attachment and growth on the nanopatterned 
      substratum. However, the patterned hPDLSC sheets showed higher periodontal 
      ligamentogenesis-related gene expression in early stages than the unpatterned 
      cell sheets. CONCLUSIONS: This experiment confirmed that patterned cell sheets 
      provide flexibility in designing hPDLSC sheets, and that these stem cell sheets 
      may be candidates for application in periodontal regenerative therapy.
FAU - Kim, Joong-Hyun
AU  - Kim JH
AUID- ORCID: 0000-0002-2219-2264
AD  - Department of Periodontology, Chonbuk National University School of Dentistry and 
      Institute of Oral Bioscience, Jeonju, Korea.
FAU - Ko, Seok-Yeong
AU  - Ko SY
AUID- ORCID: 0000-0002-0800-1409
AD  - Department of Periodontology, Chonbuk National University School of Dentistry and 
      Institute of Oral Bioscience, Jeonju, Korea.
FAU - Lee, Justin Ho
AU  - Lee JH
AUID- ORCID: 0000-0002-0284-2389
AD  - Department of Bioengineering, University of Washington, Seattle, WA, USA.
FAU - Kim, Deok-Ho
AU  - Kim DH
AUID- ORCID: 0000-0002-6989-6074
AD  - Department of Bioengineering, University of Washington, Seattle, WA, USA.
AD  - Institute for Stem Cell and Regenerative Medicine, University of Washington, 
      Seattle, WA, USA.
AD  - Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA.
FAU - Yun, Jeong-Ho
AU  - Yun JH
AUID- ORCID: 0000-0003-3929-4467
AD  - Department of Periodontology, Chonbuk National University School of Dentistry and 
      Institute of Oral Bioscience, Jeonju, Korea.
AD  - Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, 
      Korea.
AD  - Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20171231
PL  - Korea (South)
TA  - J Periodontal Implant Sci
JT  - Journal of periodontal & implant science
JID - 101526931
PMC - PMC5764766
OTO - NOTNLM
OT  - Extracellular matrix
OT  - Periodontal ligament
OT  - Regeneration
OT  - Stem cells
OT  - Tissue engineering
COIS- Conflict of Interest: Joong-Hyun Kim, Seok-Yeong Ko, Justin H. Lee and Jeong-Ho 
      Yun declare no competing financial interests. Deok-Ho Kim is a co-founder and 
      scientific board member at NanoSurface Biomedical Inc.
EDAT- 2018/01/16 06:00
MHDA- 2018/01/16 06:01
PMCR- 2017/12/01
CRDT- 2018/01/16 06:00
PHST- 2017/11/15 00:00 [received]
PHST- 2017/12/23 00:00 [accepted]
PHST- 2018/01/16 06:00 [entrez]
PHST- 2018/01/16 06:00 [pubmed]
PHST- 2018/01/16 06:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - 10.5051/jpis.2017.47.6.402 [doi]
PST - ppublish
SO  - J Periodontal Implant Sci. 2017 Dec;47(6):402-415. doi: 
      10.5051/jpis.2017.47.6.402. Epub 2017 Dec 31.