PMID- 29333460
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20211204
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2017
DP  - 2017
TI  - HLA Association with Drug-Induced Adverse Reactions.
PG  - 3186328
LID - 10.1155/2017/3186328 [doi]
LID - 3186328
AB  - Adverse drug reactions (ADRs) remain a common and major problem in healthcare. 
      Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome 
      (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to 
      more than 30%, can be life threatening. A number of recent studies demonstrated 
      that ADRs possess strong genetic predisposition. ADRs induced by several drugs 
      have been shown to have significant associations with specific alleles of human 
      leukocyte antigen (HLA) genes. For example, hypersensitivity to abacavir, a drug 
      used for treating of human immunodeficiency virus (HIV) infection, has been 
      proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B( *)57:01). 
      The incidences of abacavir hypersensitivity are much higher in Caucasians 
      compared to other populations due to various allele frequencies in different 
      ethnic populations. The antithyroid drug- (ATDs- ) induced agranulocytosis are 
      strongly associated with two alleles: HLA-B( *)38:02 and HLA-DRB1( *)08:03. In 
      addition, HLA-B( *)15:02 allele was reported to be related to 
      carbamazepine-induced SJS/TEN, and HLA-B( *)57:01 in abacavir hypersensitivity and 
      flucloxacillin induced drug-induced liver injury (DILI). In this review, we 
      summarized the alleles of HLA genes which have been proposed to have association 
      with ADRs caused by different drugs.
FAU - Fan, Wen-Lang
AU  - Fan WL
AD  - Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial 
      Hospital, Keelung, Taiwan.
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan.
FAU - Shiao, Meng-Shin
AU  - Shiao MS
AD  - Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 
      Bangkok, Thailand.
FAU - Hui, Rosaline Chung-Yee
AU  - Hui RC
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan.
AD  - Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Su, Shih-Chi
AU  - Su SC
AUID- ORCID: 0000-0002-4263-7654
AD  - Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial 
      Hospital, Keelung, Taiwan.
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan.
AD  - Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Wang, Chuang-Wei
AU  - Wang CW
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan.
FAU - Chang, Ya-Ching
AU  - Chang YC
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan.
FAU - Chung, Wen-Hung
AU  - Chung WH
AUID- ORCID: 0000-0003-1681-0959
AD  - Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial 
      Hospital, Keelung, Taiwan.
AD  - Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, 
      Chang Gung Memorial Hospital, Linkou, Taipei, Taiwan.
AD  - Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung 
      University, Taoyuan, Taiwan.
AD  - Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China.
AD  - College of Medicine, Chang Gung University, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171123
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Drug-Related Side Effects and Adverse Reactions/*genetics
MH  - Ethnicity
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Polymorphism, Genetic
PMC - PMC5733150
EDAT- 2018/01/16 06:00
MHDA- 2018/08/22 06:00
PMCR- 2017/11/23
CRDT- 2018/01/16 06:00
PHST- 2017/09/01 00:00 [received]
PHST- 2017/10/24 00:00 [accepted]
PHST- 2018/01/16 06:00 [entrez]
PHST- 2018/01/16 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
PHST- 2017/11/23 00:00 [pmc-release]
AID - 10.1155/2017/3186328 [doi]
PST - ppublish
SO  - J Immunol Res. 2017;2017:3186328. doi: 10.1155/2017/3186328. Epub 2017 Nov 23.