PMID- 29334268
OWN - NLM
STAT- MEDLINE
DCOM- 20190826
LR  - 20190826
IS  - 1556-9519 (Electronic)
IS  - 1556-3650 (Linking)
VI  - 56
IP  - 8
DP  - 2018 Aug
TI  - Analysis of the development and progression of carbon monoxide poisoning-related 
      acute kidney injury according to the Kidney Disease Improving Global Outcomes 
      (KDIGO) criteria.
PG  - 759-764
LID - 10.1080/15563650.2018.1424890 [doi]
AB  - CONTEXT: Acute kidney injury (AKI) can occur after carbon monoxide (CO) 
      intoxication; however, limited data are available. This study aimed to evaluate 
      the prognostic value of the development and progression of AKI in patients with 
      acute CO poisoning. MATERIALS AND METHODS: We conducted a retrospective cohort 
      study using a prospective registry of CO poisoning between January 2010 and 
      December 2015. AKI was defined and classified according to the Kidney Disease 
      Improving Global Outcomes (KDIGO) criteria. Multivariate logistic regression 
      analysis was conducted to determine the association between AKI and adverse 
      outcomes, defined as neurological deficits at discharge or 28-day mortality. 
      RESULTS: A total of 661 patients were evaluated. According to KDIGO criteria, 114 
      patients (17.2%) had AKI (initial: stage 1, 70.2%; stage 2, 26.3%; stage 3, 3.5%) 
      on admission and 119 (18.0%) finally developed AKI during their hospital stay 
      (maximum: stage 1, 68.9%; stage 2, 23.5%; stage 3, 7.6%). Almost all patients 
      (99.2%) were diagnosed as having their highest KDIGO stage within three days 
      (median, one day). AKI development was associated with adverse outcomes (odds 
      ratio (OR) 17.53, 95% confidence interval 45.00-77.14). Both initial and maximum 
      AKI stages demonstrated a stepwise increase of adjusted OR for adverse outcomes. 
      AKI stage progression occurred in 8.4% of patients with AKI and was an 
      independent factor for adverse outcomes. CONCLUSION: CO poisoning- related AKI 
      occurred in 18% and was mostly detected within one day after CO intoxication. The 
      development and progression of AKI had a strong association with adverse outcomes 
      and deserve further prospective investigation.
FAU - Kim, Youn-Jung
AU  - Kim YJ
AD  - a Department of Emergency Medicine , University of Ulsan College of Medicine, 
      Asan Medical Center , Seoul , Korea.
FAU - Sohn, Chang Hwan
AU  - Sohn CH
AD  - a Department of Emergency Medicine , University of Ulsan College of Medicine, 
      Asan Medical Center , Seoul , Korea.
FAU - Seo, Dong-Woo
AU  - Seo DW
AD  - a Department of Emergency Medicine , University of Ulsan College of Medicine, 
      Asan Medical Center , Seoul , Korea.
FAU - Oh, Bum Jin
AU  - Oh BJ
AD  - a Department of Emergency Medicine , University of Ulsan College of Medicine, 
      Asan Medical Center , Seoul , Korea.
FAU - Lim, Kyoung Soo
AU  - Lim KS
AD  - a Department of Emergency Medicine , University of Ulsan College of Medicine, 
      Asan Medical Center , Seoul , Korea.
FAU - Chang, Jai Won
AU  - Chang JW
AD  - b Division of Nephrology, Department of Internal Medicine , University of Ulsan 
      College of Medicine, Asan Medical Center , Seoul , Korea.
FAU - Kim, Won Young
AU  - Kim WY
AD  - a Department of Emergency Medicine , University of Ulsan College of Medicine, 
      Asan Medical Center , Seoul , Korea.
LA  - eng
PT  - Journal Article
DEP - 20180115
PL  - England
TA  - Clin Toxicol (Phila)
JT  - Clinical toxicology (Philadelphia, Pa.)
JID - 101241654
MH  - Acute Kidney Injury/*etiology/*physiopathology
MH  - Adult
MH  - Carbon Monoxide Poisoning/*complications/*physiopathology
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Acute kidney injury
OT  - carbon monoxide
OT  - complication
OT  - outcome
OT  - poisoning
EDAT- 2018/01/16 06:00
MHDA- 2019/08/27 06:00
CRDT- 2018/01/16 06:00
PHST- 2018/01/16 06:00 [pubmed]
PHST- 2019/08/27 06:00 [medline]
PHST- 2018/01/16 06:00 [entrez]
AID - 10.1080/15563650.2018.1424890 [doi]
PST - ppublish
SO  - Clin Toxicol (Phila). 2018 Aug;56(8):759-764. doi: 10.1080/15563650.2018.1424890. 
      Epub 2018 Jan 15.