PMID- 29335487
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Jan 15
TI  - Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable 
      by [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 /PET.
PG  - 748
LID - 10.1038/s41598-017-18855-0 [doi]
LID - 748
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an endocrine tumor syndrome caused 
      by heterozygous mutations in the MEN1 tumor suppressor gene. The MEN1 pancreas of 
      the adolescent gene carrier frequently contain diffusely spread pre-neoplasias 
      and microadenomas, progressing to macroscopic and potentially malignant 
      pancreatic neuroendocrine tumors (P-NET), which represents the major death cause 
      in MEN1. The unveiling of the molecular mechanism of P-NET which is not currently 
      understood fully to allow the optimization of diagnostics and treatment. 
      Glucagon-like peptide 1 (GLP-1) pathway is essential in islet regeneration, i.e. 
      inhibition of beta-cell apoptosis and enhancement of beta-cell proliferation, yet 
      involvement of GLP-1 in MEN1 related P-NET has not yet been demonstrated. The 
      objective of this work was to investigate if normal sized islets of Men1 
      heterozygous mice have increased Glucagon-like peptide-1 receptor (GLP-1R) 
      expression compared to wild type islets, and if this increase is detectable in 
      vivo with positron emission tomography (PET) using 
      [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 (68Ga-Exendin-4). 68Ga-Exendin-4 showed 
      potential for early lesion detection in MEN1 pancreas due to increased GLP1R 
      expression.
FAU - Monazzam, Azita
AU  - Monazzam A
AD  - Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
FAU - Lau, Joey
AU  - Lau J
AD  - Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
FAU - Velikyan, Irina
AU  - Velikyan I
AD  - Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
FAU - Li, Su-Chen
AU  - Li SC
AD  - Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
FAU - Razmara, Masoud
AU  - Razmara M
AD  - Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
FAU - Rosenstrom, Ulrika
AU  - Rosenstrom U
AD  - Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
FAU - Eriksson, Olof
AU  - Eriksson O
AD  - Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
FAU - Skogseid, Britt
AU  - Skogseid B
AD  - Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 
      britt.skogseid@medsci.uu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180115
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Glp1r protein, mouse)
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 0 (Men1 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Carcinoma, Neuroendocrine/*diagnostic imaging/pathology
MH  - Glucagon-Like Peptide-1 Receptor/*analysis
MH  - *Heterozygote
MH  - Mice
MH  - Pancreatic Neoplasms/*diagnostic imaging/pathology
MH  - Positron-Emission Tomography/*methods
MH  - Proto-Oncogene Proteins/*genetics
PMC - PMC5768696
COIS- The authors declare that they have no competing interests.
EDAT- 2018/01/18 06:00
MHDA- 2018/11/27 06:00
PMCR- 2018/01/15
CRDT- 2018/01/17 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2018/01/17 06:00 [entrez]
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/01/15 00:00 [pmc-release]
AID - 10.1038/s41598-017-18855-0 [pii]
AID - 18855 [pii]
AID - 10.1038/s41598-017-18855-0 [doi]
PST - epublish
SO  - Sci Rep. 2018 Jan 15;8(1):748. doi: 10.1038/s41598-017-18855-0.