PMID- 2933582
OWN - NLM
STAT- MEDLINE
DCOM- 19860121
LR  - 20190824
IS  - 0161-5890 (Print)
IS  - 0161-5890 (Linking)
VI  - 22
IP  - 9
DP  - 1985 Sep
TI  - Coordinate synthesis and degradation of the alpha-, beta- and gamma-subunits of 
      the receptor for immunoglobulin E.
PG  - 1045-51
AB  - The surface receptor for immunoglobulin E (IgE) on rat basophilic leukemia cells 
      and their normal counterparts has been postulated to consist of four polypeptide 
      chains: a 45-kDa alpha-chain which binds IgE, a 33-kDa beta-component and two 
      disulfide-linked, 9-10-kDa gamma-polypeptides. The instability of this complex in 
      mild detergents makes it possible that, in vivo also, the structure may not be 
      stable and that there is an independent assembly or exchange of the chains. We 
      studied this question using surface-labeling and biosynthetic labeling techniques 
      and found that the chains turn over coordinately and do not independently 
      exchange. The results provide further support for the proposal that the alpha 
      beta gamma 2 complex is the unit receptor for IgE.
FAU - Quarto, R
AU  - Quarto R
FAU - Kinet, J P
AU  - Kinet JP
FAU - Metzger, H
AU  - Metzger H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Receptors, Fc)
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, Immunologic)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - GMW67QNF9C (Leucine)
SB  - IM
MH  - Animals
MH  - Cell Membrane/immunology
MH  - Immunoglobulin E/metabolism
MH  - In Vitro Techniques
MH  - Iodine Radioisotopes
MH  - Leucine/metabolism
MH  - Leukemia, Experimental/immunology
MH  - Mice
MH  - Rats
MH  - Receptors, Fc/biosynthesis/*metabolism
MH  - Receptors, IgE
MH  - Receptors, Immunologic/biosynthesis/*metabolism
MH  - Structure-Activity Relationship
MH  - Time Factors
EDAT- 1985/09/01 00:00
MHDA- 1985/09/01 00:01
CRDT- 1985/09/01 00:00
PHST- 1985/09/01 00:00 [pubmed]
PHST- 1985/09/01 00:01 [medline]
PHST- 1985/09/01 00:00 [entrez]
AID - 10.1016/0161-5890(85)90107-5 [doi]
PST - ppublish
SO  - Mol Immunol. 1985 Sep;22(9):1045-51. doi: 10.1016/0161-5890(85)90107-5.