PMID- 29335823
OWN - NLM
STAT- MEDLINE
DCOM- 20191127
LR  - 20220331
IS  - 1432-055X (Electronic)
IS  - 0003-2417 (Linking)
VI  - 67
IP  - 2
DP  - 2018 Feb
TI  - [Drugs for intravenous induction of anesthesia: propofol].
PG  - 147-162
LID - 10.1007/s00101-017-0397-y [doi]
AB  - In a series of articles dealing with hypnotics for induction of anesthesia, this 
      article describes the development and current value of propofol. Its significance 
      far exceeds that of a pure induction hypnotic (sedation in diagnostic and 
      therapeutic procedures and on the intensive care unit). Propofol is also used for 
      sedation in diagnostic and therapeutic procedures and on the intensive care unit. 
      In the field of induction of anesthesia, the alternatives are barely used. Some 
      contraindications are still controversial whereas others are no longer 
      sufficiently anchored in the users' awareness (widespread off-label use). Adverse 
      effects, such as injection pain, infection risk and propofol-related infusion 
      syndrome (PRIS) could be significantly reduced by pharmacovigilance. With 
      appropriate caution nearly the whole spectrum of anesthesiology patients can be 
      treated using propofol. The hemodynamic side effects and the rare but potentially 
      fatal PRIS are limitations. Further developments address the water solubility and 
      the solubilizing agents of propofol.
FAU - Bolkenius, D
AU  - Bolkenius D
AD  - Klinik fur Anasthesiologie und Operative Intensivmedizin, Klinikum Augsburg, 
      Stenglinstr. 2, 86156, Augsburg, Deutschland. 
      Daniel.Bolkenius@klinikum-augsburg.de.
FAU - Dumps, C
AU  - Dumps C
AD  - Klinik fur Anasthesiologie und Operative Intensivmedizin, Klinikum Augsburg, 
      Stenglinstr. 2, 86156, Augsburg, Deutschland.
FAU - Halbeck, E
AU  - Halbeck E
AD  - Klinik fur Anasthesiologie und Operative Intensivmedizin, Klinikum Augsburg, 
      Stenglinstr. 2, 86156, Augsburg, Deutschland.
LA  - ger
PT  - Journal Article
TT  - Medikamente zur intravenosen Narkoseinduktion: Propofol.
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Hypnotics and Sedatives)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Anesthesia, Intravenous
MH  - Anesthetics, Intravenous/*adverse effects/*therapeutic use
MH  - Humans
MH  - Hypnotics and Sedatives/*adverse effects/*therapeutic use
MH  - Infusions, Intravenous
MH  - Intensive Care Units
MH  - Pharmacovigilance
MH  - Propofol/*adverse effects/*therapeutic use
OTO - NOTNLM
OT  - Drug-related side effects and adverse reactions
OT  - Off-label use
OT  - Pharmacodynamics
OT  - Pharmacokinetics
OT  - Propofol infusion syndrome
EDAT- 2018/01/18 06:00
MHDA- 2019/11/28 06:00
CRDT- 2018/01/17 06:00
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2019/11/28 06:00 [medline]
PHST- 2018/01/17 06:00 [entrez]
AID - 10.1007/s00101-017-0397-y [pii]
AID - 10.1007/s00101-017-0397-y [doi]
PST - ppublish
SO  - Anaesthesist. 2018 Feb;67(2):147-162. doi: 10.1007/s00101-017-0397-y.