PMID- 29336188
OWN - NLM
STAT- MEDLINE
DCOM- 20180919
LR  - 20221207
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 78
IP  - 3
DP  - 2018 May
TI  - Establishment of reference interval for the tumour marker serum CYFRA 21-1 in 
      healthy Chinese Han ethnic adults.
PG  - 171-174
LID - 10.1080/00365513.2018.1426105 [doi]
AB  - BACKGROUND: Our aim was to establish the reference interval (RI) for serum CYFRA 
      21-1 in healthy Chinese Han ethnic adults, since there has been no report about 
      it. METHODS: After screening, 9954 healthy Chinese Han adults (age range 
      18-95 years) were recruited, including 6639 (66.7%) males and 3315 (33.3%) 
      females. Electrochemiluminescence immunoassay was used to measure serum 
      CYFRA21-1. The RI was defined by nonparametric 95% percentile interval. RESULTS: 
      The distribution for serum CYFRA21-1 level was non-Gaussian. The RI for healthy 
      Chinese Han adults calculated by nonparametric method was 0-4.47 ng/ml in this 
      study, higher than that recommended by Roche Diagnostics GmbH (</=3.3 ng/ml). The 
      reference values were higher in males than females before 50 years of age, 
      although the difference was hardly seen after 50 years of age. The reference 
      value increased with age in both males and females. Of slight difference, the 
      increase of male reference value was obvious at 60-69 and more than 80 years of 
      age, while that of female obvious at 50-69 and more than 80 years of age. 
      CONCLUSIONS: We establish the RI for serum CYFRA21-1 in healthy Chinese Han 
      population, which is higher than that recommended by Roche Diagnostics GmbH. 
      Furthermore, our study suggests that it is necessary to establish the age- and 
      sex-specific RIs for serum CYFRA21-1.
FAU - Zhao, Bing
AU  - Zhao B
AD  - a Department of Laboratory Medicine , Taizhou First People's Hospital, Huangyan 
      Hospital Affiliated to Wenzhou Medical University , Zhejiang , China.
FAU - Zhang, Miaomiao
AU  - Zhang M
AD  - a Department of Laboratory Medicine , Taizhou First People's Hospital, Huangyan 
      Hospital Affiliated to Wenzhou Medical University , Zhejiang , China.
FAU - Liu, Donghong
AU  - Liu D
AD  - a Department of Laboratory Medicine , Taizhou First People's Hospital, Huangyan 
      Hospital Affiliated to Wenzhou Medical University , Zhejiang , China.
FAU - Ren, Yingpeng
AU  - Ren Y
AD  - a Department of Laboratory Medicine , Taizhou First People's Hospital, Huangyan 
      Hospital Affiliated to Wenzhou Medical University , Zhejiang , China.
FAU - Xie, Jing
AU  - Xie J
AD  - a Department of Laboratory Medicine , Taizhou First People's Hospital, Huangyan 
      Hospital Affiliated to Wenzhou Medical University , Zhejiang , China.
FAU - Liang, Yan
AU  - Liang Y
AD  - b Department of Laboratory Diagnostics , Changzheng Hospital, Second Military 
      Medical University , Shanghai , China.
FAU - Yang, Zaixing
AU  - Yang Z
AD  - a Department of Laboratory Medicine , Taizhou First People's Hospital, Huangyan 
      Hospital Affiliated to Wenzhou Medical University , Zhejiang , China.
LA  - eng
PT  - Journal Article
DEP - 20180116
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Keratin-19)
RN  - 0 (antigen CYFRA21.1)
SB  - IM
CIN - Scand J Clin Lab Invest. 2018 Jul;78(4):335-336. PMID: 29533118
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Neoplasm/*blood
MH  - Asian People
MH  - Biomarkers, Tumor/*blood
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Immunoassay/*standards
MH  - Keratin-19/*blood
MH  - Luminescent Measurements
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Sex Factors
OTO - NOTNLM
OT  - CYFRA21-1
OT  - Chinese
OT  - adult
OT  - reference interval
EDAT- 2018/01/18 06:00
MHDA- 2018/09/20 06:00
CRDT- 2018/01/17 06:00
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/09/20 06:00 [medline]
PHST- 2018/01/17 06:00 [entrez]
AID - 10.1080/00365513.2018.1426105 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2018 May;78(3):171-174. doi: 
      10.1080/00365513.2018.1426105. Epub 2018 Jan 16.