PMID- 29336612
OWN - NLM
STAT- MEDLINE
DCOM- 20181109
LR  - 20181109
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 40
IP  - 7
DP  - 2018
TI  - Relationship among adiponectin, insulin resistance and atherosclerosis in 
      non-diabetic hypertensive patients and healthy adults.
PG  - 656-663
LID - 10.1080/10641963.2018.1425414 [doi]
AB  - Adiponectin, which is secreted specifically by adipose tissue, has been shown to 
      have anti-atherogenic and anti-inflammatory effects and to improve insulin 
      resistance (IR). The aim of this study was to determine the correlations among 
      adiponectin, IR and atherosclerosis in non-diabetic hypertensive patients and 
      healthy volunteers. In this case control study, we collected complete demographic 
      data from and measured several laboratory parameters in all enrolled subjects. 
      The homeostasis model of assessment for insulin resistance (HOMA-IR) was 
      calculated as an insulin sensitivity index. The atherogenic index of plasma 
      (AIP), which is calculated as log (triglyceride (TG)/high-density lipoprotein 
      cholesterol (HDL-C)), was a significant predictor of atherosclerosis and was a 
      better predictor of atherosclerosis than low-density lipoprotein cholesterol 
      (LDL-C). Plasma adiponectin, interleukin (IL)-6, monocyte chemoattractant 
      protein-1 (MCP-1) and matrix metalloprotein-9 (MMP-9) concentrations were 
      determined using enzyme-linked immunosorbent assay (ELISA). All data were 
      analyzed using Statistical Product and Service Solutions for Windows (SPSS) 13.0 
      software. A total of 309 participants were enrolled in the study. Hypertensive 
      patients with IR (n = 93) displayed significantly higher HOMA-IR values and AIPs 
      and lower adiponectin levels than hypertensive patients without IR (n = 121) and 
      healthy adults (n = 95) (P < 0.05). Furthermore, circulating IL-6, MCP-1 and 
      MMP-9 concentrations differed significantly between hypertensive patients and 
      healthy adults (P < 0.05). Additionally, adiponectin levels were found to be 
      inversely correlated with IL-6, MCP-1, and MMP-9 levels; HOMA-IR values; and AIPs 
      in the clinical study. HOMA-IR values and adiponectin and creatinine (Cr) 
      concentrations remained independently associated with AIPs in all participants 
      after adjustment for confounders via multivariate linear regression. Low 
      adiponectin levels are positively correlated with decreased insulin sensitivity, 
      increased pro-inflammatory cytokine production and worsening atherosclerosis in 
      hypertensive patients and healthy adults.
FAU - Kou, Huijuan
AU  - Kou H
AD  - a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
FAU - Deng, Jie
AU  - Deng J
AD  - a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
FAU - Gao, Dengfeng
AU  - Gao D
AD  - a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
FAU - Song, Anqi
AU  - Song A
AD  - a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
FAU - Han, Zhenhua
AU  - Han Z
AD  - a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
FAU - Wei, Jin
AU  - Wei J
AD  - a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
FAU - Jin, Xin
AU  - Jin X
AD  - b Department of Ultrasonography , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
FAU - Ma, Rui
AU  - Ma R
AD  - a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
FAU - Zheng, Qiangsun
AU  - Zheng Q
AD  - a Department of Cardiology , The Second Affiliated Hospital, Xi'an Jiaotong 
      University , Xi'an , Shaanxi , P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180116
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Triglycerides)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adiponectin/*blood
MH  - Aged
MH  - Atherosclerosis/*blood
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Creatinine/blood
MH  - Female
MH  - Homeostasis
MH  - Humans
MH  - Hypertension/blood/*physiopathology
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Interleukin-6/blood
MH  - Male
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Triglycerides/blood
OTO - NOTNLM
OT  - AIP
OT  - Adiponectin
OT  - HOMA-IR
OT  - Insulin resistance
OT  - atherosclerosis
OT  - hypertension
EDAT- 2018/01/18 06:00
MHDA- 2018/11/10 06:00
CRDT- 2018/01/17 06:00
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
PHST- 2018/01/17 06:00 [entrez]
AID - 10.1080/10641963.2018.1425414 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2018;40(7):656-663. doi: 10.1080/10641963.2018.1425414. Epub 
      2018 Jan 16.