PMID- 29337020
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20221207
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 28
IP  - 3
DP  - 2018 Mar
TI  - Inverse association between plasma homocysteine concentrations and type 2 
      diabetes mellitus among a middle-aged and elderly Chinese population.
PG  - 278-284
LID - S0939-4753(17)30297-1 [pii]
LID - 10.1016/j.numecd.2017.11.009 [doi]
AB  - BACKGROUND AND AIMS: Plasma homocysteine concentrations have been reported to be 
      associated with type 2 diabetes mellitus (T2DM) with controversial findings. The 
      aim of the present study was to investigate the association between plasma 
      homocysteine concentrations and T2DM. METHODS AND RESULTS: A cross-sectional 
      study including 19,085 eligible participants derived from the Dongfeng-Tongji 
      cohort was conducted. Plasma homocysteine concentrations were measured by Abbott 
      Architect i2000 Automatic analyzer and T2DM was defined according to American 
      Diabetes Association criteria. Logistic regression model was used to explore the 
      association between plasma homocysteine concentrations and T2DM. The prevalence 
      of T2DM was 19.0% in the whole population (mean age 62.9 years), 21.8% in males, 
      and 17.1% in females. In the multivariable logistic regression analyses, compared 
      with those in the lowest quintile, the OR (95% CI) of T2DM was 1.05 (0.92-1.21), 
      0.99 (0.86-1.14), 0.90 (0.78-1.05), and 0.77 (0.66-0.90) for quintile 2 to 
      quintile 5 of homocysteine concentrations after adjustment for potential 
      confounders (P for trend < 0.0001). Homocysteine concentrations were associated 
      with decreased T2DM prevalence risk (OR = 0.88 per SD increase of homocysteine 
      concentration; 95% CI: 0.84-0.93). A significant interaction between homocysteine 
      concentrations and drinking status on T2DM prevalence risk was observed (P for 
      interaction = 0.03). The inverse association of plasma homocysteine 
      concentrations with T2DM prevalence risk was observed in non-drinkers but not in 
      current drinkers. CONCLUSION: Plasma homocysteine concentrations were inversely 
      correlated with T2DM among a middle-aged and elderly Chinese population.
CI  - Copyright (c) 2017 The Italian Society of Diabetology, the Italian Society for the 
      Study of Atherosclerosis, the Italian Society of Human Nutrition, and the 
      Department of Clinical Medicine and Surgery, Federico II University. Published by 
      Elsevier B.V. All rights reserved.
FAU - Yu, C
AU  - Yu C
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Wang, J
AU  - Wang J
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Wang, F
AU  - Wang F
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Han, X
AU  - Han X
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Hu, H
AU  - Hu H
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Yuan, J
AU  - Yuan J
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Miao, X
AU  - Miao X
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Yao, P
AU  - Yao P
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Wei, S
AU  - Wei S
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Wang, Y
AU  - Wang Y
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Liang, Y
AU  - Liang Y
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Chen, W
AU  - Chen W
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Zhang, X
AU  - Zhang X
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Guo, H
AU  - Guo H
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Yang, H
AU  - Yang H
AD  - Dongfeng Central Hospital, Dongfeng Motor Corporation and Hubei University of 
      Medicine, Shiyan, Hubei, China.
FAU - Tang, Y
AU  - Tang Y
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Zheng, D
AU  - Zheng D
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Wu, T
AU  - Wu T
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - He, M
AU  - He M
AD  - Department of Occupational and Environmental Health and State Key Laboratory of 
      Environmental Health for Incubating, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 
      Electronic address: hemeian@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171207
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Alcohol Drinking/adverse effects/blood/epidemiology
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/epidemiology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/diagnosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
OTO - NOTNLM
OT  - Glycated haemoglobin
OT  - Homocysteine
OT  - Hyperglycemia
OT  - Impaired fasting glucose
OT  - Type 2 diabetes mellitus
EDAT- 2018/01/18 06:00
MHDA- 2019/03/15 06:00
CRDT- 2018/01/17 06:00
PHST- 2017/06/20 00:00 [received]
PHST- 2017/11/16 00:00 [revised]
PHST- 2017/11/27 00:00 [accepted]
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
PHST- 2018/01/17 06:00 [entrez]
AID - S0939-4753(17)30297-1 [pii]
AID - 10.1016/j.numecd.2017.11.009 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2018 Mar;28(3):278-284. doi: 
      10.1016/j.numecd.2017.11.009. Epub 2017 Dec 7.