PMID- 29337185
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20180830
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 538
IP  - 1-2
DP  - 2018 Mar 1
TI  - Proliposome tablets manufactured using a slurry-driven lipid-enriched powders: 
      Development, characterization and stability evaluation.
PG  - 250-262
LID - S0378-5173(17)31193-6 [pii]
LID - 10.1016/j.ijpharm.2017.12.049 [doi]
AB  - Proliposome powders were prepared via a slurry method using sorbitol or 
      D-mannitol as carbohydrate carriers in 1:10 or 1:15 w/w lipid phase to carrier 
      ratios. Soya phosphatidylcholine (SPC) and cholesterol were employed as a lipid 
      phase and Beclometasone dipropionate (BDP) was incorporated as a model drug. 
      Direct compaction using a Minipress was applied on the lipid-enriched powder in 
      order to manufacture proliposome tablets. Sorbitol-based proliposome tablets in a 
      1:15 w/w ratio were found to be the best formulation as it exhibited excellent 
      powder flowability with an angle of repose of 25.62 +/- 1.08 degrees , and when compacted 
      the resultant tablets had low friability (0.20 +/- 0.03%), appropriate hardness 
      (crushing strength) (120.67 +/- 12.04 N), short disintegration time 
      (5.85 +/- 0.66 min), and appropriate weight uniformity. Moreover, upon hydration 
      into liposomes, the entrapment efficiency for sorbitol formulations in both 1:10 
      and 1:15 lipid to carrier ratios were significantly higher (53.82 +/- 6.42% and 
      57.43 +/- 9.12%) than D-mannitol formulations (39.90 +/- 4.30% and 35.22 +/- 6.50%), 
      respectively. Extended stability testing was conducted for 18 months, at three 
      different temperature conditions (Fridge Temperature (FT; 6  degrees C), Room Temperature 
      (RT; 22  degrees C) and High Temperature (HT; 40  degrees C)) for sorbitol-based proliposome 
      tablets (1:15 w/w ratio). Volume median diameter (VMD) and zeta potential 
      significantly changed from 5.90 +/- 0.70 microm to 14.79 +/- 0.79 microm and from 
      -3.08 +/- 0.26 mV to -11.97 +/- 0.26 mV respectively at month 18, when samples were 
      stored under HT conditions. Moreover, the entrapment efficiency of BDP decreased 
      from 57.43 +/- 9.12% to 17.93 +/- 5.37% following 18 months storage under HT 
      conditions. Overall, in this study for the first time, proliposome tablets were 
      manufactured and thoroughly characterized, and sorbitol showed to be a promising 
      carrier.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Khan, Iftikhar
AU  - Khan I
AD  - School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 
      Liverpool L3 3AF, United Kingdom; Institute of Nanotechnology and Bioengineering, 
      University of Central Lancashire, Preston PR1 2HE, United Kingdom; School of 
      Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 
      2HE, United Kingdom. Electronic address: I.Khan@ljmu.ac.uk.
FAU - Yousaf, Sakib
AU  - Yousaf S
AD  - Institute of Nanotechnology and Bioengineering, University of Central Lancashire, 
      Preston PR1 2HE, United Kingdom; School of Pharmacy and Biomedical Sciences, 
      University of Central Lancashire, Preston PR1 2HE, United Kingdom.
FAU - Subramanian, Sneha
AU  - Subramanian S
AD  - Institute of Nanotechnology and Bioengineering, University of Central Lancashire, 
      Preston PR1 2HE, United Kingdom; School of Pharmacy and Biomedical Sciences, 
      University of Central Lancashire, Preston PR1 2HE, United Kingdom.
FAU - Albed Alhnan, Mohamed
AU  - Albed Alhnan M
AD  - Institute of Nanotechnology and Bioengineering, University of Central Lancashire, 
      Preston PR1 2HE, United Kingdom; School of Pharmacy and Biomedical Sciences, 
      University of Central Lancashire, Preston PR1 2HE, United Kingdom.
FAU - Ahmed, Waqar
AU  - Ahmed W
AD  - School of Mathematics and Physics, College of Science, University of Lincoln, 
      Lincoln LN6 7TS, United Kingdom.
FAU - Elhissi, Abdelbary
AU  - Elhissi A
AD  - Pharmaceutical Sciences Section, College of Pharmacy, Qatar University, P.O. Box 
      2713, Doha, Qatar. Electronic address: aelhissi@qu.edu.qa.
LA  - eng
PT  - Journal Article
DEP - 20180112
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Drug Carriers)
RN  - 0 (Lipids)
RN  - 0 (Liposomes)
RN  - 0 (Phosphatidylcholines)
RN  - 0 (Powders)
RN  - 0 (Tablets)
RN  - 3OWL53L36A (Mannitol)
RN  - 506T60A25R (Sorbitol)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - KGZ1SLC28Z (Beclomethasone)
SB  - IM
MH  - Beclomethasone/*administration & dosage/chemistry
MH  - Chemistry, Pharmaceutical/*methods
MH  - Cholesterol/chemistry
MH  - Drug Carriers/*chemistry
MH  - Drug Stability
MH  - Hardness
MH  - Lipids/*chemistry
MH  - Liposomes
MH  - Mannitol/chemistry
MH  - Particle Size
MH  - Phosphatidylcholines/chemistry
MH  - Powders
MH  - Sorbitol/chemistry
MH  - Tablets
MH  - Temperature
OTO - NOTNLM
OT  - Beclometasone dipropionate
OT  - D-mannitol
OT  - Liposome
OT  - Proliposome
OT  - Sorbitol
OT  - Tablets
EDAT- 2018/01/18 06:00
MHDA- 2018/08/31 06:00
CRDT- 2018/01/17 06:00
PHST- 2017/10/12 00:00 [received]
PHST- 2017/12/20 00:00 [revised]
PHST- 2017/12/30 00:00 [accepted]
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
PHST- 2018/01/17 06:00 [entrez]
AID - S0378-5173(17)31193-6 [pii]
AID - 10.1016/j.ijpharm.2017.12.049 [doi]
PST - ppublish
SO  - Int J Pharm. 2018 Mar 1;538(1-2):250-262. doi: 10.1016/j.ijpharm.2017.12.049. 
      Epub 2018 Jan 12.