PMID- 29339100
OWN - NLM
STAT- MEDLINE
DCOM- 20180817
LR  - 20210109
IS  - 2352-3964 (Electronic)
IS  - 2352-3964 (Linking)
VI  - 28
DP  - 2018 Feb
TI  - Genetic Variation in the Dopamine System Influences Intervention Outcome in 
      Children with Cerebral Palsy.
PG  - 162-167
LID - S2352-3964(17)30509-1 [pii]
LID - 10.1016/j.ebiom.2017.12.028 [doi]
AB  - BACKGROUND: There is large variation in treatment responses in children with 
      cerebral palsy. Experimental and clinical results suggest that dopamine 
      neurotransmission and brain-derived neurotrophic factor (BDNF) signalling are 
      involved in motor learning and plasticity, which are key factors in modern 
      habilitation success. We examined whether naturally occurring variations in 
      dopamine and BDNF genes influenced the treatment outcomes. METHODS: Thirty-three 
      children (18-60months of age) with spastic unilateral cerebral palsy were 
      enrolled in the study. Each child had participated in a training programme 
      consisting of active training of the involved hand for 2h every day during a 
      2-month training period. The training outcome was measured using Assisting Hand 
      Assessment before and after the training period. Saliva was collected for 
      genotyping of COMT, DAT, DRD1, DRD2, DRD3, and BDNF. Regression analyses were 
      used to examine associations between genetic variation and training outcome. 
      FINDINGS: There was a statistically significant association between variation in 
      dopamine genes and treatment outcome. Children with a high polygenic dopamine 
      gene score including polymorphisms of five dopamine genes (COMT, DAT, DRD1, DRD2, 
      and DRD3), and reflecting higher endogenous dopaminergic neurotransmission, had 
      the greatest functional outcome gains after intervention. INTERPRETATION: 
      Naturally occurring genetic variation in the dopamine system can influence 
      treatment outcomes in children with cerebral palsy. A polygenic dopamine score 
      might be valid for treatment outcome prediction and for designing individually 
      tailored interventions for children with cerebral palsy.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Diaz Heijtz, Rochellys
AU  - Diaz Heijtz R
AD  - Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
FAU - Almeida, Rita
AU  - Almeida R
AD  - Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
FAU - Eliasson, Ann Christin
AU  - Eliasson AC
AD  - Department of Women's and Children's Health, Karolinska Institutet, Astrid 
      Lindgren Children's Hospital, Stockholm, Sweden.
FAU - Forssberg, Hans
AU  - Forssberg H
AD  - Department of Women's and Children's Health, Karolinska Institutet, Astrid 
      Lindgren Children's Hospital, Stockholm, Sweden. Electronic address: 
      hans.forssberg@ki.se.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180109
PL  - Netherlands
TA  - EBioMedicine
JT  - EBioMedicine
JID - 101647039
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Cerebral Palsy/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Dopamine/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Variation
MH  - Humans
MH  - Infant
MH  - Linear Models
MH  - Male
MH  - Multifactorial Inheritance/genetics
MH  - Treatment Outcome
PMC - PMC5835543
OTO - NOTNLM
OT  - Cerebral palsy
OT  - Dopamine genes
OT  - Hand motor assessment
OT  - Intervention
EDAT- 2018/01/18 06:00
MHDA- 2018/08/18 06:00
PMCR- 2018/01/09
CRDT- 2018/01/18 06:00
PHST- 2017/11/21 00:00 [received]
PHST- 2017/12/20 00:00 [revised]
PHST- 2017/12/22 00:00 [accepted]
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/08/18 06:00 [medline]
PHST- 2018/01/18 06:00 [entrez]
PHST- 2018/01/09 00:00 [pmc-release]
AID - S2352-3964(17)30509-1 [pii]
AID - 10.1016/j.ebiom.2017.12.028 [doi]
PST - ppublish
SO  - EBioMedicine. 2018 Feb;28:162-167. doi: 10.1016/j.ebiom.2017.12.028. Epub 2018 
      Jan 9.