PMID- 29339519
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20211204
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 115
IP  - 5
DP  - 2018 Jan 30
TI  - Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.
PG  - 968-973
LID - 10.1073/pnas.1715531115 [doi]
AB  - Primate-specific Alu short interspersed elements (SINEs) as well as 
      rodent-specific B and ID (B/ID) SINEs can promote Staufen-mediated decay (SMD) 
      when present in mRNA 3'-untranslated regions (3'-UTRs). The transposable nature 
      of SINEs, their presence in long noncoding RNAs, their interactions with Staufen, 
      and their rapid divergence in different evolutionary lineages suggest they could 
      have generated substantial modification of posttranscriptional gene-control 
      networks during mammalian evolution. Some of the variation in SMD regulation 
      produced by SINE insertion might have had a similar regulatory effect in separate 
      mammalian lineages, leading to parallel evolution of the Staufen network by 
      independent expansion of lineage-specific SINEs. To explore this possibility, we 
      searched for orthologous gene pairs, each carrying a species-specific 3'-UTR SINE 
      and each regulated by SMD, by measuring changes in mRNA abundance after 
      individual depletion of two SMD factors, Staufen1 (STAU1) and UPF1, in both human 
      and mouse myoblasts. We identified and confirmed orthologous gene pairs with 
      3'-UTR SINEs that independently function in SMD control of myoblast metabolism. 
      Expanding to other species, we demonstrated that SINE-directed SMD likely emerged 
      in both primate and rodent lineages >20-25 million years ago. Our work reveals a 
      mechanism for the convergent evolution of posttranscriptional gene regulatory 
      networks in mammals by species-specific SINE transposition and SMD.
FAU - Lucas, Bronwyn A
AU  - Lucas BA
AD  - Department of Biochemistry and Biophysics, School of Medicine and Dentistry, 
      University of Rochester Medical Center, Rochester, NY 14642.
AD  - Center for RNA Biology, University of Rochester, Rochester, NY 14642.
FAU - Lavi, Eitan
AU  - Lavi E
AD  - Department of Genetics, Alexander Silberman Institute of Life Sciences, Faculty 
      of Science, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
FAU - Shiue, Lily
AU  - Shiue L
AD  - Center for Molecular Biology of RNA, Department of Molecular, Cell and 
      Developmental Biology, University of California, Santa Cruz, CA 95064.
FAU - Cho, Hana
AU  - Cho H
AD  - Department of Biochemistry and Biophysics, School of Medicine and Dentistry, 
      University of Rochester Medical Center, Rochester, NY 14642.
AD  - Center for RNA Biology, University of Rochester, Rochester, NY 14642.
FAU - Katzman, Sol
AU  - Katzman S
AD  - Center for Biomolecular Science and Engineering, University of California, Santa 
      Cruz, CA 95064.
FAU - Miyoshi, Keita
AU  - Miyoshi K
AD  - Department of Biochemistry and Biophysics, School of Medicine and Dentistry, 
      University of Rochester Medical Center, Rochester, NY 14642.
AD  - Center for RNA Biology, University of Rochester, Rochester, NY 14642.
FAU - Siomi, Mikiko C
AU  - Siomi MC
AD  - Graduate School of Science, University of Tokyo, Tokyo 113-0032, Japan.
FAU - Carmel, Liran
AU  - Carmel L
AD  - Department of Genetics, Alexander Silberman Institute of Life Sciences, Faculty 
      of Science, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
FAU - Ares, Manuel Jr
AU  - Ares M Jr
AD  - Center for Molecular Biology of RNA, Department of Molecular, Cell and 
      Developmental Biology, University of California, Santa Cruz, CA 95064; 
      ares@ucsc.edu lynne_maquat@urmc.rochester.edu.
FAU - Maquat, Lynne E
AU  - Maquat LE
AD  - Department of Biochemistry and Biophysics, School of Medicine and Dentistry, 
      University of Rochester Medical Center, Rochester, NY 14642; ares@ucsc.edu 
      lynne_maquat@urmc.rochester.edu.
AD  - Center for RNA Biology, University of Rochester, Rochester, NY 14642.
LA  - eng
SI  - figshare/10.6084/m9.figshare.4765015
GR  - R01 GM040478/GM/NIGMS NIH HHS/United States
GR  - R37 GM074593/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20180116
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Pyruvate Dehydrogenase Acetyl-Transferring Kinase)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (staufen protein, mammalian)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - 3' Untranslated Regions
MH  - AT Rich Sequence
MH  - Animals
MH  - *Evolution, Molecular
MH  - Humans
MH  - Mice
MH  - Protein Serine-Threonine Kinases/genetics/metabolism
MH  - Pyruvate Dehydrogenase Acetyl-Transferring Kinase
MH  - RNA Stability/*genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - RNA-Binding Proteins/genetics/*metabolism
MH  - *Short Interspersed Nucleotide Elements
PMC - PMC5798355
OTO - NOTNLM
OT  - SINEs
OT  - Staufen-mediated mRNA decay
OT  - Staufen1
OT  - UPF1
OT  - convergent evolution
COIS- The authors declare no conflict of interest.
EDAT- 2018/01/18 06:00
MHDA- 2018/07/17 06:00
PMCR- 2018/07/30
CRDT- 2018/01/18 06:00
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2018/01/18 06:00 [entrez]
PHST- 2018/07/30 00:00 [pmc-release]
AID - 1715531115 [pii]
AID - 201715531 [pii]
AID - 10.1073/pnas.1715531115 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):968-973. doi: 
      10.1073/pnas.1715531115. Epub 2018 Jan 16.