PMID- 29339649 OWN - NLM STAT- MEDLINE DCOM- 20190903 LR - 20190903 IS - 1661-6758 (Electronic) IS - 1661-6499 (Linking) VI - 10 IP - 5-6 DP - 2017 TI - Cardiovascular Risk Factors and Insulin Resistance after Two Hypocaloric Diets with Different Fat Distribution in Obese Subjects: Effect of the rs10767664 Gene Variant in Brain-Derived Neurotrophic Factor. PG - 163-171 LID - 10.1159/000485248 [doi] AB - BACKGROUND: The role of brain-derived neurotrophic factor (BDNF) variants on change in body weight and cardiovascular risk factors after weight loss remains unclear in obese patients. OBJECTIVE: Our aim was to analyze the effects of the rs10767664 BDNF gene polymorphism on body weight, cardiovascular risk factors, and serum adipokine levels after a high monounsaturated fatty acids (MUFAs) hypocaloric diet (diet M) versus a high polyunsaturated fatty acids (PUFAs) hypocaloric diet (diet P). METHODS: A Caucasian population of 361 obese patients was enrolled. Subjects who met the inclusion criteria were randomly allocated to one of two diets for a period of 3 months. RESULTS: Two hundred and sixteen subjects (59.8%) had the genotype AA (wild-type group), and 145 (40.2%) patients had the genotypes AT (122 patients, 33.8%) or TT (23 patients, 6.4%) (mutant-type group). After weight loss with diet P and diet M and in both genotype groups, body mass index, weight, fat mass, waist circumference, systolic blood pressure, serum leptin levels, low-density lipoprotein cholesterol, and total cholesterol decreased in a significant way. Secondary to weight loss with diet M and only in the wild-type group, insulin levels (-2.1 +/- 2.0 vs. -0.7 +/- 2.9 IU/L, p < 0.05) and homeostatic model assessment of insulin resistance (-0.7 +/- 0.9 vs. -0.3 +/- 1.0 U, p < 0.05) decreased. CONCLUSION: Our data show that the rs10767664 variant of the BDNF gene modifies insulin resistance and insulin levels after weight loss with a hypocaloric diet enriched with MUFAs. CI - (c) 2018 S. Karger AG, Basel. FAU - de Luis, Daniel Antonio AU - de Luis DA AD - Center of Investigation of Endocrinology and Nutrition, Medical School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, Simancas, Spain. FAU - Romero, Enrique AU - Romero E FAU - Izaola, Olatz AU - Izaola O FAU - Primo, David AU - Primo D FAU - Aller, Rocio AU - Aller R LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180117 PL - Switzerland TA - J Nutrigenet Nutrigenomics JT - Journal of nutrigenetics and nutrigenomics JID - 101299758 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Dietary Fats) RN - 0 (Fatty Acids, Monounsaturated) RN - 0 (Insulin) RN - 7171WSG8A2 (BDNF protein, human) MH - Adult MH - Aged MH - Brain-Derived Neurotrophic Factor/*genetics MH - *Caloric Restriction MH - Cardiovascular Diseases/etiology/*genetics MH - Dietary Fats/administration & dosage MH - Fatty Acids, Monounsaturated/administration & dosage MH - Humans MH - Insulin/blood MH - Insulin Resistance/*genetics MH - Middle Aged MH - Nutrigenomics MH - Obesity/complications/*diet therapy/*genetics MH - Polymorphism, Single Nucleotide MH - Risk Factors MH - Weight Loss MH - Young Adult OTO - NOTNLM OT - Adipokines OT - Brain-derived neurotrophic factor OT - Hypocaloric diets OT - Insulin resistance OT - rs10767664 EDAT- 2018/01/18 06:00 MHDA- 2019/09/04 06:00 CRDT- 2018/01/18 06:00 PHST- 2017/09/26 00:00 [received] PHST- 2017/11/14 00:00 [accepted] PHST- 2018/01/18 06:00 [pubmed] PHST- 2019/09/04 06:00 [medline] PHST- 2018/01/18 06:00 [entrez] AID - 000485248 [pii] AID - 10.1159/000485248 [doi] PST - ppublish SO - J Nutrigenet Nutrigenomics. 2017;10(5-6):163-171. doi: 10.1159/000485248. Epub 2018 Jan 17.