PMID- 29340297
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 6
IP  - 1
DP  - 2018 Jan
TI  - Acetic acid-guided biopsies in Barrett's surveillance for neoplasia detection 
      versus non-targeted biopsies (Seattle protocol): A feasibility study for a 
      randomized tandem endoscopy trial. The ABBA study.
PG  - E43-E50
LID - 10.1055/s-0043-120829 [doi]
AB  - BACKGROUND AND STUDY AIMS: Barrett's esophagus is a potentially pre-cancerous 
      condition, affecting 375,000 people in the UK. Patients receive a 2-yearly 
      endoscopy to detect cancerous changes, as early detection and treatment results 
      in better outcomes. Current treatment requires random mapping biopsies along the 
      length of Barrett's, in addition to biopsy of visible abnormalities. As only 13 % 
      of pre-cancerous changes appear as visible nodules or abnormalities, areas of 
      dysplasia are often missed. Acetic acid chromoendoscopy (AAC) has been shown to 
      improve detection of pre-cancerous and cancerous tissue in observational studies, 
      but no randomized controlled trials (RCTs) have been performed to date. PATIENTS 
      AND METHODS: A "tandem" endoscopy cross-over design. Participants will be 
      randomized to endoscopy using mapping biopsies or AAC, in which dilute acetic 
      acid is sprayed onto the surface of the esophagus, highlighting tissue through an 
      whitening reaction and enhancing visibility of areas with cellular changes for 
      biopsy. After 4 to 10 weeks, participants will undergo a repeat endoscopy, using 
      the second method. Rates of recruitment and retention will be assessed, in 
      addition to the estimated dysplasia detection rate, effectiveness of the 
      endoscopist training program, and rates of adverse events (AEs). Qualitative 
      interviews will explore participant and endoscopist acceptability of study design 
      and delivery, and the acceptability of switching endoscopic techniques for 
      Barrett's surveillance. RESULTS: Endoscopists' ability to diagnose dysplasia in 
      Barrett's esophagus can be improved. AAC may offer a simple, universally 
      applicable, easily-acquired technique to improve detection, affording patients 
      earlier diagnosis and treatment, reducing endoscopy time and pathology costs. The 
      ABBA study will determine whether a crossover "tandem" endoscopy design is 
      feasible and acceptable to patients and clinicians and gather outcome data to 
      power a definitive trial.
FAU - Chedgy, Fergus
AU  - Chedgy F
AD  - Portsmouth Hospitals NHS Trust, Portsmouth, UK.
FAU - Fogg, Carole
AU  - Fogg C
AD  - University of Portsmouth, Portsmouth.
FAU - Kandiah, Kesavan
AU  - Kandiah K
AD  - Portsmouth Hospitals NHS Trust, Portsmouth, UK.
FAU - Barr, Hugh
AU  - Barr H
AD  - Royal Gloucestershire Hospital, Gloucester, Gloucestershire, UK.
FAU - Higgins, Bernard
AU  - Higgins B
AD  - University of Portsmouth, Portsmouth.
FAU - McCord, Mimi
AU  - McCord M
AD  - Heartburn Cancer UK, Basingstoke, Hampshire, UK.
FAU - Dewey, Ann
AU  - Dewey A
AD  - University of Portsmouth, Portsmouth.
FAU - De Caestecker, John
AU  - De Caestecker J
AD  - Leicester General Hospital, Leicester, UK.
FAU - Gadeke, Lisa
AU  - Gadeke L
AD  - Portsmouth Hospitals NHS Trust, Portsmouth, UK.
FAU - Stokes, Clive
AU  - Stokes C
AD  - Royal Gloucestershire Hospital, Gloucester, Gloucestershire, UK.
FAU - Poller, David
AU  - Poller D
AD  - Portsmouth Hospitals NHS Trust, Portsmouth, UK.
FAU - Longcroft-Wheaton, Gaius
AU  - Longcroft-Wheaton G
AD  - Portsmouth Hospitals NHS Trust, Portsmouth, UK.
FAU - Bhandari, Pradeep
AU  - Bhandari P
AD  - Portsmouth Hospitals NHS Trust, Portsmouth, UK.
LA  - eng
GR  - PB-PG-1013-32045/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20180112
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC5766339
COIS- Competing interests None. The ABBA study is funded by the National Institute for 
      Health Research, Research for Patient Benefit (Project Number PB-PG-1013-32045).
EDAT- 2018/01/18 06:00
MHDA- 2018/01/18 06:01
PMCR- 2018/01/01
CRDT- 2018/01/18 06:00
PHST- 2017/01/16 00:00 [received]
PHST- 2017/06/30 00:00 [accepted]
PHST- 2018/01/18 06:00 [entrez]
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/01/18 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.1055/s-0043-120829 [doi]
PST - ppublish
SO  - Endosc Int Open. 2018 Jan;6(1):E43-E50. doi: 10.1055/s-0043-120829. Epub 2018 Jan 
      12.