PMID- 29341420
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20180925
IS  - 1365-2443 (Electronic)
IS  - 1356-9597 (Linking)
VI  - 23
IP  - 3
DP  - 2018 Mar
TI  - Transgenic mice specifically expressing amphiregulin in white adipose tissue 
      showed less adipose tissue mass.
PG  - 136-145
LID - 10.1111/gtc.12558 [doi]
AB  - To determine adipocytokines that play a regulatory role during obesity 
      development, we explored the genes that encode growth factors and investigated 
      the physiological functions for adipose tissue development. Here, we isolated 
      amphiregulin (Areg) gene whose expression was significantly up-regulated in obese 
      adipose tissues. Areg mRNA level was positively correlated with macrophage marker 
      gene expression in adipose tissues in vivo. Unexpectedly, Areg transgenic mice 
      showed less adipose tissue mass with increased mRNA expression levels of Tnf-alpha 
      and peroxisome proliferator-activated receptor gamma coactivator 1alpha (Pgc-1alpha) and 
      delayed white adipose tissue development during the convalescent stage in a 
      dextran sodium sulfate-induced colitis model. This study showed that Areg mRNA 
      expression was significantly up-regulated in obese adipose tissues and 
      over-expression of Areg in white adipose tissue caused less adipose tissue mass.
CI  - (c) 2018 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.
FAU - Yang, Bo
AU  - Yang B
AD  - Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 
      Japan.
FAU - Kumoto, Takahiro
AU  - Kumoto T
AD  - Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 
      Japan.
FAU - Arima, Takeshi
AU  - Arima T
AD  - Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 
      Japan.
FAU - Nakamura, Minako
AU  - Nakamura M
AD  - Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 
      Japan.
FAU - Sanada, Yohei
AU  - Sanada Y
AD  - Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 
      Japan.
FAU - Kumrungsee, Thanutchaporn
AU  - Kumrungsee T
AD  - Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 
      Japan.
FAU - Sotomaru, Yusuke
AU  - Sotomaru Y
AD  - Natural Science Center for Basic Research and Development, Hiroshima University, 
      Hiroshima, Japan.
FAU - Shimada, Masayuki
AU  - Shimada M
AD  - Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 
      Japan.
FAU - Yanaka, Noriyuki
AU  - Yanaka N
AUID- ORCID: 0000-0002-9564-0822
AD  - Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20180117
PL  - England
TA  - Genes Cells
JT  - Genes to cells : devoted to molecular & cellular mechanisms
JID - 9607379
RN  - 0 (Amphiregulin)
RN  - 0 (Areg protein, mouse)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Adipose Tissue, White/metabolism/*pathology
MH  - Amphiregulin/genetics/*metabolism
MH  - Animals
MH  - Colitis/chemically induced/metabolism/*pathology
MH  - Dextran Sulfate/toxicity
MH  - *Disease Models, Animal
MH  - Female
MH  - Gene Expression Profiling
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Obesity/*physiopathology
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 
      1-alpha/genetics/metabolism
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
OTO - NOTNLM
OT  - amphiregulin
OT  - obese development
OT  - white adipose tissue
EDAT- 2018/01/18 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/01/18 06:00
PHST- 2017/10/03 00:00 [received]
PHST- 2017/12/12 00:00 [accepted]
PHST- 2018/01/18 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/01/18 06:00 [entrez]
AID - 10.1111/gtc.12558 [doi]
PST - ppublish
SO  - Genes Cells. 2018 Mar;23(3):136-145. doi: 10.1111/gtc.12558. Epub 2018 Jan 17.